%0 Journal Article %B Berliner und Münchener Tierärztliche Wochenschrift %C Hannover %D 2008 %G English %I M. & H. Schaper GmbH %P 444-448 %R 10.2376/0341-6593-115-444 %T Concentrations of ß-carotene (Carofertin®)and vitamin A in plasma of pigs after intramuscular injection of ß-carotene %V 115 %1 {"oldId":70959,"title":"Concentrations of \u00df-carotene (Carofertin\u00ae)and vitamin A in plasma of pigs after intramuscular injection of \u00df-carotene","teaserText":"pharmacokinetics, \u03b2-carotene, pig, Pharmakokinetik, \u03b2-Carotin, Schwein","content":"

Summary<\/span>
Limited information is available about the absorption and distribution of parenterally administered amp;#946;-carotene in pigs. Therefore plasma concentrations and pharmacokinetic parameters of amp;#946;-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered amp;#946;-carotene preparation (Carofertin\u00ae) were analysed. Five gilts were injected with a single dose of 70 mg amp;#946;-carotene in an injectable aqueous solution. The mean pre-treatment plasma amp;#946;-carotene concentration was below 10 amp;#956;g\/ml. After injection, plasma amp;#946;-carotene values increased rapidly and reached a peak of 13.8 \u00b1 5.4 amp;#956;g\/ml after 24 hours. For a duration of 72 hours, plasma amp;#946;-carotene concentrations were significantly increased compared to baseline values (p

Zusammenfassung<\/span>
\u00dcber die Resorption und Verteilung von parenteral appliziertem amp;#946;-Carotin beim Schwein liegen nur begrenzt Informationen vor. In der vorliegenden Arbeit wurden daher die Konzentration im Blutplasma und die Pharmakokinetik von amp;#946;-Carotin, Effekte auf die Vitamin-A-Konzentration im Blutplasma sowie die Vertr\u00e4glichhkeit eines intramuskul\u00e4r applizierten amp;#946;-Carotinpr\u00e4parates (Carofertin\u00ae) untersucht. Insgesamt 5 Jungsauen wurden mit 70 mg amp;#946;-Carotin in w\u00e4ssriger L\u00f6sung behandelt. Vor der Behandlung lag die mittlere amp;#946;-Carotinkonzentration im Plasma unter 10 amp;#956;g\/ml und stieg auf ein Maximum von 13,8 \u00b1 5,4 amp;#956;g\/ml 24 Stunden nach der Behandlung an. \u00dcber 72 Stunden war die amp;#946;-Carotinkonzentration gegen\u00fcber den vor der Injektion erhobenen Basalwerten sigifikant erh\u00f6ht (p <\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Dec 1, 2008 12:00:00 AM","toDate":"Dec 31, 2050 12:00:00 AM","oldUrls":["http:\/\/vetline.de\/pharmacokinetics-carotene-pig\/150\/3130\/70959"],"doiLanguage":"englisch","doiProductFormat":"Online","doiPublisher":"M. & H. Schaper GmbH","doiSerialWorkTitle":"Dtsch.tier\u00e4rztl.Wschr.","doiDocumentUri":"http:\/\/www.vetline.de\/pharmacokinetics-carotene-pig\/150\/3130\/70959","doiSource":"Dtsch.tier\u00e4rztl.Wschr. 115: 12, 444-448 (2008)","doiissn":"0341-6593","doiNr":"10.2376\/0341-6593-115-444","doiFirstPage":"444","doiLastPage":"448","doiTransmitted":true,"doiAuthor":"Krammer G, Aurich J","pdf":{"path":"http:\/\/data\/dtw_2008_12_0444.pdf","title":"dtw_2008_12_0444.pdf","description":"Concentrations of \u00df-carotene (Carofertin\u00ae)and vitamin A in plasma of pigs after intramuscular injection of \u00df-carotene

"},"authors":[{"firstName":"G","middleName":"","lastName":"Krammer"},{"firstName":"J","middleName":"","lastName":"Aurich"}],"contentOptimised":"

Summary<\/strong>
Limited information is available about the absorption and distribution of parenterally administered amp;#946;-carotene in pigs. Therefore plasma concentrations and pharmacokinetic parameters of amp;#946;-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered amp;#946;-carotene preparation (Carofertin\u00ae) were analysed. Five gilts were injected with a single dose of 70 mg amp;#946;-carotene in an injectable aqueous solution. The mean pre-treatment plasma amp;#946;-carotene concentration was below 10 amp;#956;g\/ml. After injection, plasma amp;#946;-carotene values increased rapidly and reached a peak of 13.8 \u00b1 5.4 amp;#956;g\/ml after 24 hours. For a duration of 72 hours, plasma amp;#946;-carotene concentrations were significantly increased compared to baseline values (p

Zusammenfassung<\/strong>
\u00dcber die Resorption und Verteilung von parenteral appliziertem amp;#946;-Carotin beim Schwein liegen nur begrenzt Informationen vor. In der vorliegenden Arbeit wurden daher die Konzentration im Blutplasma und die Pharmakokinetik von amp;#946;-Carotin, Effekte auf die Vitamin-A-Konzentration im Blutplasma sowie die Vertr\u00e4glichhkeit eines intramuskul\u00e4r applizierten amp;#946;-Carotinpr\u00e4parates (Carofertin\u00ae) untersucht. Insgesamt 5 Jungsauen wurden mit 70 mg amp;#946;-Carotin in w\u00e4ssriger L\u00f6sung behandelt. Vor der Behandlung lag die mittlere amp;#946;-Carotinkonzentration im Plasma unter 10 amp;#956;g\/ml und stieg auf ein Maximum von 13,8 \u00b1 5,4 amp;#956;g\/ml 24 Stunden nach der Behandlung an. \u00dcber 72 Stunden war die amp;#946;-Carotinkonzentration gegen\u00fcber den vor der Injektion erhobenen Basalwerten sigifikant erh\u00f6ht (p <\/p>","primaryLanguage":"englisch","summary":"Limited information is available about the absorption and distribution of parenterally administered amp;#946;-carotene in pigs. Therefore plasma concentrations and pharmacokinetic parameters of amp;#946;-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered amp;#946;-carotene preparation (Carofertin\u00ae) were analysed. Five gilts were injected with a single dose of 70 mg amp;#946;-carotene in an injectable aqueous solution. The mean pre-treatment plasma amp;#946;-carotene concentration was below 10 amp;#956;g\/ml. After injection, plasma amp;#946;-carotene values increased rapidly and reached a peak of 13.8 \u00b1 5.4 amp;#956;g\/ml after 24 hours. For a duration of 72 hours, plasma amp;#946;-carotene concentrations were significantly increased compared to baseline values (p","zusammenfassung":"\u00dcber die Resorption und Verteilung von parenteral appliziertem amp;#946;-Carotin beim Schwein liegen nur begrenzt Informationen vor. In der vorliegenden Arbeit wurden daher die Konzentration im Blutplasma und die Pharmakokinetik von amp;#946;-Carotin, Effekte auf die Vitamin-A-Konzentration im Blutplasma sowie die Vertr\u00e4glichhkeit eines intramuskul\u00e4r applizierten amp;#946;-Carotinpr\u00e4parates (Carofertin\u00ae) untersucht. Insgesamt 5 Jungsauen wurden mit 70 mg amp;#946;-Carotin in w\u00e4ssriger L\u00f6sung behandelt. Vor der Behandlung lag die mittlere amp;#946;-Carotinkonzentration im Plasma unter 10 amp;#956;g\/ml und stieg auf ein Maximum von 13,8 \u00b1 5,4 amp;#956;g\/ml 24 Stunden nach der Behandlung an. \u00dcber 72 Stunden war die amp;#946;-Carotinkonzentration gegen\u00fcber den vor der Injektion erhobenen Basalwerten sigifikant erh\u00f6ht (p <\/p>","translatedTitle":"pharmacokinetics, \u03b2-carotene, pig, Pharmakokinetik, \u03b2-Carotin, Schwein","abstractE":"Limited information is available about the absorption and distribution of parenterally administered amp;#946;-carotene in pigs. Therefore plasma concentrations and pharmacokinetic parameters of amp;#946;-carotene, its influence on plasma vitamin A concentration as well as the safety and tolerability of an intramuscularly administered amp;#946;-carotene preparation (Carofertin\u00ae) were analysed. Five gilts were injected with a single dose of 70 mg amp;#946;-carotene in an injectable aqueous solution. The mean pre-treatment plasma amp;#946;-carotene concentration was below 10 amp;#956;g\/ml. After injection, plasma amp;#946;-carotene values increased rapidly and reached a peak of 13.8 \u00b1 5.4 amp;#956;g\/ml after 24 hours. For a duration of 72 hours, plasma amp;#946;-carotene concentrations were significantly increased compared to baseline values (p","date":{"year":2008,"date":"12\/2008","accepted":"2008-12-01"},"volume":"115","openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"444-448","redirects":["pharmacokinetics-carotene-pig\/150\/3130\/70959"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} %8 12/2008