%0 Journal Article %B Berliner und Münchener Tierärztliche Wochenschrift %C Hannover %D 2008 %G English %I M. & H. Schaper GmbH %P 15-19 %R 10.2377/0341-6593-115-15 %T The effect of kefir on glutathione (gsh), malondialdehyde (MDA) and nitric oxide (NO) levels in mice with colonic abnormal crypt formation (AcF) induced by azoxymethane (AOM) %V 115 %1 {"oldId":69171,"title":"The effect of kefir on glutathione (gsh), malondialdehyde (MDA) and nitric oxide (NO) levels in mice with colonic abnormal crypt formation (AcF) induced by azoxymethane (AOM)","teaserText":"Azoxymethane, colonic aberrant crypt formation, kefir, Azoxymethan, abnormale Kryptenbildung, Kefir","content":"

Summary<\/span>
In this study we investigated the effect of kefir on the levels of glutathione (GSH),malondialdehyde (MDA), nitric oxide (NO) in the liver, stomach, spleen and colonof mice with colonic aberrant crypts formed by azoxymethane (AOM). Thirty 1weeks old Swiss Albino mice averaging 31.5 g weight were used as experimentalanimals. The mice were separated into 3 groups. The first group was the controlgroup, second group was the AOM and third group was the AOM+kefir group.We applied AOM to the second and third groups. Mice were fed ad libitum bylaboratory rodent chow during the experiment period. Water was given to thefirst and second groups and third group received only kefir diluted with water(50 %). AOM was injected subcutaneously to the second and third groups for 7weeks (two times a week, 5 mg\/kg). Six weeks after the final AOM treatment theanimals were sacrificed and liver, stomach, spleen and colon samples were collectedfrom all the groups. MDA level demonstrated an increase only in stomachfor the third group (p

Zusammenfassung<\/span>
Untersucht wurden die Auswirkungen von Kefir auf den Gehalt an Glutathion(GSH), Malondialdehyd (MDA) und Stickoxid (NO) in Leber, Magen, Milz undDickdarm von M\u00e4usen mit abnormaler Kryptenbildung im Darm, hervorgerufendurch Azoxymethan (AOM). Hierzu wurden 30 zw\u00f6lf Wochen alte Swiss Albino-M\u00e4use mit einem Durchschnittsgewicht von 31,5 g als Versuchstiere eingesetztund in drei Gruppen aufgeteilt. Die erste Gruppe diente als Kontrolle, die zweitewar die AOM-Gruppe und die dritte die AOM+Kefir-Gruppe. Die zweite und dritteGruppe erhielt AOM. W\u00e4hrend des Experimentes wurden die M\u00e4use ad libitummit Labornagerfutter gef\u00fcttert. Die ersten beiden Gruppen erhielten Wasser,die dritte mit Wasser verd\u00fcnntes Kefir (50 %). Das AOM wurde der zweiten unddritten Gruppe \u00fcber sieben Wochen hinweg subkutan verabreicht (zweimal proWoche, 5 mg\/kg). Sechs Wochen nach der letzten AOM-Behandlung wurdendie Tiere get\u00f6tet und von allen Gruppen Proben der Leber, des Magens, der Milzund des Dickdarms genommen. Der MDA-Gehalt ergab bei der dritten Gruppe nur f\u00fcr den Magen eine Zunahme (p <\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Jan 1, 2008 12:00:00 AM","toDate":"Dec 31, 2050 12:00:00 AM","oldUrls":["http:\/\/vetline.de\/azoxymethane-colonic-aberrant-crypt-formation-kefir\/150\/3130\/69171"],"doiLanguage":"englisch","doiProductFormat":"Online","doiPublisher":"M. & H. Schaper GmbH","doiSerialWorkTitle":"Dtsch.tier\u00e4rztl.Wschr.","doiDocumentUri":"http:\/\/www.vetline.de\/azoxymethane-colonic-aberrant-crypt-formation-kefir\/150\/3130\/69171","doiSource":"Dtsch.tier\u00e4rztl.Wschr. 115: 1, 15-19 (2008)","doiissn":"0341-6593","doiNr":"10.2377\/0341-6593-115-15","doiFirstPage":"15","doiLastPage":"19","doiTransmitted":true,"doiAuthor":"CENESIZ S, DEVRIM A K, KAMBER U, SOZMEN M","pdf":{"path":"http:\/\/data\/dtw_2008_01_0015.pdf","title":"dtw_2008_01_0015.pdf","description":"The effect of kefir on glutathione (gsh), malondialdehyde (MDA) and nitric oxide (NO) levels in mice with colonic abnormal crypt formation (AcF) induced by azoxymethane (AOM)

"},"authors":[{"firstName":"C","middleName":"ENESIZS","lastName":""},{"firstName":"D","middleName":"EVRIMAK","lastName":""},{"firstName":"K","middleName":"AMBERU","lastName":""},{"firstName":"S","middleName":"OZMENM","lastName":""}],"contentOptimised":"

Summary<\/strong>
In this study we investigated the effect of kefir on the levels of glutathione (GSH),malondialdehyde (MDA), nitric oxide (NO) in the liver, stomach, spleen and colonof mice with colonic aberrant crypts formed by azoxymethane (AOM). Thirty 1weeks old Swiss Albino mice averaging 31.5 g weight were used as experimentalanimals. The mice were separated into 3 groups. The first group was the controlgroup, second group was the AOM and third group was the AOM+kefir group.We applied AOM to the second and third groups. Mice were fed ad libitum bylaboratory rodent chow during the experiment period. Water was given to thefirst and second groups and third group received only kefir diluted with water(50 %). AOM was injected subcutaneously to the second and third groups for 7weeks (two times a week, 5 mg\/kg). Six weeks after the final AOM treatment theanimals were sacrificed and liver, stomach, spleen and colon samples were collectedfrom all the groups. MDA level demonstrated an increase only in stomachfor the third group (p

Zusammenfassung<\/strong>
Untersucht wurden die Auswirkungen von Kefir auf den Gehalt an Glutathion(GSH), Malondialdehyd (MDA) und Stickoxid (NO) in Leber, Magen, Milz undDickdarm von M\u00e4usen mit abnormaler Kryptenbildung im Darm, hervorgerufendurch Azoxymethan (AOM). Hierzu wurden 30 zw\u00f6lf Wochen alte Swiss Albino-M\u00e4use mit einem Durchschnittsgewicht von 31,5 g als Versuchstiere eingesetztund in drei Gruppen aufgeteilt. Die erste Gruppe diente als Kontrolle, die zweitewar die AOM-Gruppe und die dritte die AOM+Kefir-Gruppe. Die zweite und dritteGruppe erhielt AOM. W\u00e4hrend des Experimentes wurden die M\u00e4use ad libitummit Labornagerfutter gef\u00fcttert. Die ersten beiden Gruppen erhielten Wasser,die dritte mit Wasser verd\u00fcnntes Kefir (50 %). Das AOM wurde der zweiten unddritten Gruppe \u00fcber sieben Wochen hinweg subkutan verabreicht (zweimal proWoche, 5 mg\/kg). Sechs Wochen nach der letzten AOM-Behandlung wurdendie Tiere get\u00f6tet und von allen Gruppen Proben der Leber, des Magens, der Milzund des Dickdarms genommen. Der MDA-Gehalt ergab bei der dritten Gruppe nur f\u00fcr den Magen eine Zunahme (p <\/p>","primaryLanguage":"englisch","summary":"In this study we investigated the effect of kefir on the levels of glutathione (GSH),malondialdehyde (MDA), nitric oxide (NO) in the liver, stomach, spleen and colonof mice with colonic aberrant crypts formed by azoxymethane (AOM). Thirty 1weeks old Swiss Albino mice averaging 31.5 g weight were used as experimentalanimals. The mice were separated into 3 groups. The first group was the controlgroup, second group was the AOM and third group was the AOM+kefir group.We applied AOM to the second and third groups. Mice were fed ad libitum bylaboratory rodent chow during the experiment period. Water was given to thefirst and second groups and third group received only kefir diluted with water(50 %). AOM was injected subcutaneously to the second and third groups for 7weeks (two times a week, 5 mg\/kg). Six weeks after the final AOM treatment theanimals were sacrificed and liver, stomach, spleen and colon samples were collectedfrom all the groups. MDA level demonstrated an increase only in stomachfor the third group (p","zusammenfassung":"Untersucht wurden die Auswirkungen von Kefir auf den Gehalt an Glutathion(GSH), Malondialdehyd (MDA) und Stickoxid (NO) in Leber, Magen, Milz undDickdarm von M\u00e4usen mit abnormaler Kryptenbildung im Darm, hervorgerufendurch Azoxymethan (AOM). Hierzu wurden 30 zw\u00f6lf Wochen alte Swiss Albino-M\u00e4use mit einem Durchschnittsgewicht von 31,5 g als Versuchstiere eingesetztund in drei Gruppen aufgeteilt. Die erste Gruppe diente als Kontrolle, die zweitewar die AOM-Gruppe und die dritte die AOM+Kefir-Gruppe. Die zweite und dritteGruppe erhielt AOM. W\u00e4hrend des Experimentes wurden die M\u00e4use ad libitummit Labornagerfutter gef\u00fcttert. Die ersten beiden Gruppen erhielten Wasser,die dritte mit Wasser verd\u00fcnntes Kefir (50 %). Das AOM wurde der zweiten unddritten Gruppe \u00fcber sieben Wochen hinweg subkutan verabreicht (zweimal proWoche, 5 mg\/kg). Sechs Wochen nach der letzten AOM-Behandlung wurdendie Tiere get\u00f6tet und von allen Gruppen Proben der Leber, des Magens, der Milzund des Dickdarms genommen. Der MDA-Gehalt ergab bei der dritten Gruppe nur f\u00fcr den Magen eine Zunahme (p <\/p>","translatedTitle":"Azoxymethane, colonic aberrant crypt formation, kefir, Azoxymethan, abnormale Kryptenbildung, Kefir","abstractE":"In this study we investigated the effect of kefir on the levels of glutathione (GSH),malondialdehyde (MDA), nitric oxide (NO) in the liver, stomach, spleen and colonof mice with colonic aberrant crypts formed by azoxymethane (AOM). Thirty 1weeks old Swiss Albino mice averaging 31.5 g weight were used as experimentalanimals. The mice were separated into 3 groups. The first group was the controlgroup, second group was the AOM and third group was the AOM+kefir group.We applied AOM to the second and third groups. Mice were fed ad libitum bylaboratory rodent chow during the experiment period. Water was given to thefirst and second groups and third group received only kefir diluted with water(50 %). AOM was injected subcutaneously to the second and third groups for 7weeks (two times a week, 5 mg\/kg). Six weeks after the final AOM treatment theanimals were sacrificed and liver, stomach, spleen and colon samples were collectedfrom all the groups. MDA level demonstrated an increase only in stomachfor the third group (p","date":{"year":2008,"date":"01\/2008","accepted":"2008-01-01"},"volume":"115","openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"15-19","redirects":["azoxymethane-colonic-aberrant-crypt-formation-kefir\/150\/3130\/69171"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} %8 01/2008