%0 Journal Article %K adjuvants %K veterinary vaccines %B Berliner und Münchener Tierärztliche Wochenschrift %C Hannover %D 2015 %G English %I Schlütersche Verlagsgesellschaft mbH & Co. KG %P 456-463 %R 10.2376/0005-9366-128-456 %T Adjuvants for veterinary vaccines – types and modes of action %V 128 %1 {"oldId":91408,"title":"Adjuvants for veterinary vaccines \u2013 types and modes of action","topline":"BMTW Themenheft Impfstrategien & Immunmodulation","teaserText":"Adjuvantien f\u00fcr Veterin\u00e4rimpfstoffe \u2013 Typen und Wirkweise","content":"

Summary: <\/span><\/p>

Adjuvants are used to improve the immune response to vaccines. Formulation with adjuvants can result in an earlier onset of immunity, an overall stronger immune response, a specific type of immunity, or a longer duration of immunity to the vaccine. Adjuvants were discovered empirically, and for decades, have been used in both humans and animals without understanding the mechanisms of action. With an improved understanding of the immune system, and in particular the interplay between innate and adaptive immunity, we are now getting better insight into the function of adjuvants. As a result, new adjuvants are being developed that are safe and highly effective for common use in humans and animals, as well as for use in high risk populations such as immunocompromised animals, neonates or very old animals. Furthermore, adjuvants can help to reduce the amount of antigen needed in the vaccine, increase the stability of the vaccine and enable alternative administration routes such as needle-free delivery of the vaccine. Here, I will provide an overview of the existing adjuvant technologies for veterinary vaccines and provide an outlook into some of the new technologies in preclinical and clinical development. <\/p>

Keywords:<\/span> adjuvants, veterinary vaccines<\/p>

Zusammenfassung:<\/span><\/p>

Adjuvantien sind wichtige Bestandteile von Impfstoffen und werden zur Steigerung der Wirksamkeit verwendet. Adjuvantien k\u00f6nnen unter anderem zu einer schnelleren und l\u00e4nger anhaltenden Immunantwort f\u00fchren, sowie einen bestimmten Typ der Immunantwort einleiten. Adjuvantien wurden in den letzten hundert Jahren zumeist empirisch eingesetzt; erst in den letzten Jahren hat sich durch ein besseres Verst\u00e4ndnis des Zusammenspiels von angeborener und erworbener Immunit\u00e4t eine eigene Forschungsrichtung etabliert. So wurden in den vergangenen Jahren verschiedene neuartige Adjuvantien f\u00fcr human- und veterin\u00e4rmedizinische Anwendungen entwickelt, welche zum Beispiel die Wirksamkeit des Impfstoffes verbessern, die Stabilit\u00e4t erh\u00f6hen und die Menge des ben\u00f6tigen Antigens reduzieren k\u00f6nnen. Dieser Artikel beschreibt die Wirkungsweise von Adjuvantien und stellt einige veterin\u00e4rmedizinisch relevante Adjuvantien vor.<\/p>

Sch\u00fcsselw\u00f6rter: <\/span>Adjuvantien, Veterin\u00e4rvakzinen<\/p>","categories":["Open Access","Abostufe frei"],"fromDate":"Nov 5, 2015 10:07:25 AM","oldUrls":["http:\/\/vetline.de\/adjuvants-for-veterinary-vaccines-types-and-modes-of-action\/150\/3216\/91408"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr","doiDocumentUri":"http:\/\/cf01.vetline.schluetersche.de\/files\/smfiledata\/5\/2\/2\/6\/7\/6\/BMW_2015_11_12_0456_onl300.pdf","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr 128, 456\u2013463","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-128-456","doiFirstPage":"456","doiLastPage":"463","doiTransmitted":true,"doiAuthor":"Gerdts V","pdf":{"path":"http:\/\/data\/BMW_2015_11_12_0456_onl300.pdf","title":"OA Gerdts Adjuvants for veterinary vaccines","description":"Adjuvantien f\u00fcr Veterin\u00e4rimpfstoffe \u2013 Typen und Wirkweise"},"authors":[{"firstName":"V","middleName":"","lastName":"Gerdts"}],"contentOptimised":"

Summary<\/strong><\/p>

Adjuvants are used to improve the immune response to vaccines. Formulation with adjuvants can result in an earlier onset of immunity, an overall stronger immune response, a specific type of immunity, or a longer duration of immunity to the vaccine. Adjuvants were discovered empirically, and for decades, have been used in both humans and animals without understanding the mechanisms of action. With an improved understanding of the immune system, and in particular the interplay between innate and adaptive immunity, we are now getting better insight into the function of adjuvants. As a result, new adjuvants are being developed that are safe and highly effective for common use in humans and animals, as well as for use in high risk populations such as immunocompromised animals, neonates or very old animals. Furthermore, adjuvants can help to reduce the amount of antigen needed in the vaccine, increase the stability of the vaccine and enable alternative administration routes such as needle-free delivery of the vaccine. Here, I will provide an overview of the existing adjuvant technologies for veterinary vaccines and provide an outlook into some of the new technologies in preclinical and clinical development. <\/p>

Keywords:<\/strong> adjuvants, veterinary vaccines<\/p>

Zusammenfassung<\/strong><\/p>

Adjuvantien sind wichtige Bestandteile von Impfstoffen und werden zur Steigerung der Wirksamkeit verwendet. Adjuvantien k\u00f6nnen unter anderem zu einer schnelleren und l\u00e4nger anhaltenden Immunantwort f\u00fchren, sowie einen bestimmten Typ der Immunantwort einleiten. Adjuvantien wurden in den letzten hundert Jahren zumeist empirisch eingesetzt; erst in den letzten Jahren hat sich durch ein besseres Verst\u00e4ndnis des Zusammenspiels von angeborener und erworbener Immunit\u00e4t eine eigene Forschungsrichtung etabliert. So wurden in den vergangenen Jahren verschiedene neuartige Adjuvantien f\u00fcr human- und veterin\u00e4rmedizinische Anwendungen entwickelt, welche zum Beispiel die Wirksamkeit des Impfstoffes verbessern, die Stabilit\u00e4t erh\u00f6hen und die Menge des ben\u00f6tigen Antigens reduzieren k\u00f6nnen. Dieser Artikel beschreibt die Wirkungsweise von Adjuvantien und stellt einige veterin\u00e4rmedizinisch relevante Adjuvantien vor.<\/p>

Sch\u00fcsselw\u00f6rter: <\/strong>Adjuvantien, Veterin\u00e4rvakzinen<\/p>","primaryLanguage":"englisch","summary":"<\/p>

Adjuvants are used to improve the immune response to vaccines. Formulation with adjuvants can result in an earlier onset of immunity, an overall stronger immune response, a specific type of immunity, or a longer duration of immunity to the vaccine. Adjuvants were discovered empirically, and for decades, have been used in both humans and animals without understanding the mechanisms of action. With an improved understanding of the immune system, and in particular the interplay between innate and adaptive immunity, we are now getting better insight into the function of adjuvants. As a result, new adjuvants are being developed that are safe and highly effective for common use in humans and animals, as well as for use in high risk populations such as immunocompromised animals, neonates or very old animals. Furthermore, adjuvants can help to reduce the amount of antigen needed in the vaccine, increase the stability of the vaccine and enable alternative administration routes such as needle-free delivery of the vaccine. Here, I will provide an overview of the existing adjuvant technologies for veterinary vaccines and provide an outlook into some of the new technologies in preclinical and clinical development. <\/p>

","keywords":["adjuvants","veterinary vaccines"],"zusammenfassung":"<\/p>

Adjuvantien sind wichtige Bestandteile von Impfstoffen und werden zur Steigerung der Wirksamkeit verwendet. Adjuvantien k\u00f6nnen unter anderem zu einer schnelleren und l\u00e4nger anhaltenden Immunantwort f\u00fchren, sowie einen bestimmten Typ der Immunantwort einleiten. Adjuvantien wurden in den letzten hundert Jahren zumeist empirisch eingesetzt; erst in den letzten Jahren hat sich durch ein besseres Verst\u00e4ndnis des Zusammenspiels von angeborener und erworbener Immunit\u00e4t eine eigene Forschungsrichtung etabliert. So wurden in den vergangenen Jahren verschiedene neuartige Adjuvantien f\u00fcr human- und veterin\u00e4rmedizinische Anwendungen entwickelt, welche zum Beispiel die Wirksamkeit des Impfstoffes verbessern, die Stabilit\u00e4t erh\u00f6hen und die Menge des ben\u00f6tigen Antigens reduzieren k\u00f6nnen. Dieser Artikel beschreibt die Wirkungsweise von Adjuvantien und stellt einige veterin\u00e4rmedizinisch relevante Adjuvantien vor.<\/p>

Sch\u00fcsselw\u00f6rter: <\/strong>Adjuvantien, Veterin\u00e4rvakzinen<\/p>","translatedTitle":"Adjuvantien f\u00fcr Veterin\u00e4rimpfstoffe \u2013 Typen und Wirkweise","abstractE":"Adjuvants are used to improve the immune response to vaccines. Formulation with adjuvants can result in an earlier onset of immunity, an overall stronger immune response, a specific type of immunity, or a longer duration of immunity to the vaccine. Adjuvants were discovered empirically, and for decades, have been used in both humans and animals without understanding the mechanisms of action. With an improved understanding of the immune system, and in particular the interplay between innate and adaptive immunity, we are now getting better insight into the function of adjuvants. As a result, new adjuvants are being developed that are safe and highly effective for common use in humans and animals, as well as for use in high risk populations such as immunocompromised animals, neonates or very old animals. Furthermore, adjuvants can help to reduce the amount of antigen needed in the vaccine, increase the stability of the vaccine and enable alternative administration routes such as needle-free delivery of the vaccine. Here, I will provide an overview of the existing adjuvant technologies for veterinary vaccines and provide an outlook into some of the new technologies in preclinical and clinical development. ","date":{"year":2015,"date":"11\/2015","accepted":"2015-11-05"},"volume":"128","openAccess":true,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"456-463","redirects":["adjuvants-for-veterinary-vaccines-types-and-modes-of-action\/150\/3216\/91408"],"tierartCategories":[],"artikelartCategories":["Open Access","Abostufe frei"]} %8 11/2015