%0 Journal Article %K cattle %K pain %K analgesia %K metamizole %K Meloxicam %B Berliner und Münchener Tierärztliche Wochenschrift %C Hannover %D 2018 %G English %I Schlütersche Verlagsgesellschaft mbH & Co. KG %R 10.2376/0005-9366-17103 %T Course of plasma substance P concentrations during umbilical surgery in calves %V 131 %1 {"oldId":107787,"title":"Course of plasma substance P concentrations during umbilical surgery in calves","topline":"","teaserText":"Verlauf von Substanz P Konzentrationen im Blutplasma w\u00e4hrend einer Nabeloperation bei K\u00e4lbern","content":"

Summary<\/span>
The objective of this orientating study was to describe plasma concentrations of substance P in calves undergoing umbilical surgery with two different analgesic protocols. The study was conducted as a randomized controlled double blinded trial. Ten calves (aged 39 \u00b1 10 days) were treated with meloxicam (CON) for analgesia, and 11 calves (aged 37 \u00b1 8 days) with meloxicam and metamizole (MET). Umbilical surgery under general anaesthesia was performed according to a strictly standardized protocol. Blood samples were taken at the day of surgery (one hour before and 5, 15, 30, 45, 60, 90, 150 and 510 minutes after skin incision). Plasma concentrations and AUC of substance P were determined. Plasma substance P increased during umbilical surgery in both groups. In CON, there was a significant difference to plasma substance P baseline concentration 5, 30 and 90 minutes after skin incision. Plasma substance P concentrations were lower in MET compared with CON at all times, and did not differ significantly from baseline concentration. Even though there was no significant difference in the plasma substance P concentrations in-between the groups, the results show that after the administration of metamizole additionally to meloxicam, plasma substance P concentrations in MET were lower than in CON at all times. This fact could indicate that substance P might be a suitable biomarker for nociception and pain. Further studies are needed to confirm this hypothesis.<\/p>

Keywords<\/span>
cattle, pain, analgesia, metamizole, meloxicam<\/p>

Zusammenfassung<\/span>
Das Ziel dieser orientierenden Studie war es, den Substanz P Gehalt im Blutplasma von K\u00e4lbern vor, w\u00e4hrend und nach einer Nabelbruchoperation zu bestimmen. Die K\u00e4lber wurden mit zwei verschiedenen Analgesieprotokollen behandelt. Die Studie war doppelt verblindet. Zehn K\u00e4lber (39 \u00b1 10 Tage alt) der Gruppe CON erhielten Meloxicam, elf K\u00e4lber der Gruppe MET (37 \u00b1 8 Tage alt) Meloxicam und Metamizol. Die Nabeloperation wurde gem\u00e4\u00df einem standardisierten Protokoll unter Allgemeinan\u00e4sthesie durchgef\u00fchrt. Blutproben wurden am Tag der Operation (eine Stunde vorher (Basiskonzentration) und 5, 15, 30, 45, 60, 90, 150 und 510 Minuten nach dem Hautschnitt) genommen. Plasma-Konzentrationen und die AUC von Substanz P wurden ermittelt. Substanz P Konzentrationen stiegen w\u00e4hrend der Operation in beiden Gruppen an. In der CON-Gruppe zeigte sich ein signifikanter Unterschied zur Basiskonzentration zu den Zeitpunkten 5, 30 und 90 Minuten nach dem Hautschnitt. In der MET-Gruppe waren die Substanz P Konzentrationen zu allen Messzeitpunkten niedriger als in der CON-Gruppe, jedoch zu keinem Zeitpunkt signifikant. Die Applikation von Metamizol als Add-on zus\u00e4tzlich zu Meloxicam f\u00fchrte zu einem geringeren Anstieg von Substanz P zu allen Zeitpunkten w\u00e4hrend und nach der Operation. Diese Tatsache k\u00f6nnte ein Hinweis darauf sein, dass Substanz P ein geeigneter Biomarker zur Objektivierung von Nociception beim Kalb sein k\u00f6nnte. Zuk\u00fcnftige, weitere Studien sind n\u00f6tig um diese Hypothese zu untermauern. Der positive analgetische Effekt von Metamizol ist bei Nabeloperationen zu empfehlen.<\/p>

Schl\u00fcsselw\u00f6rter<\/span>
Rind, Schmerz, Analgesie, Metamizol, Meloxicam<\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Apr 26, 2018 12:24:27 PM","oldUrls":["http:\/\/vetline.de\/course-of-plasma-substance-p-concentrations-during-umbilical-surgery-in-calves\/150\/3130\/107787"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl M\u00fcnch Tier\u00e4rztl Wochensch","doiDocumentUri":"https:\/\/vetline.de\/files\/smfiledata\/7\/1\/5\/5\/5\/4\/BMTW_AOP_17103_Tschoner_onl300.pdf","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochensch","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-17103","doiFirstPage":".","doiLastPage":"..","doiTransmitted":true,"doiAuthor":"Tschoner T, Behrendt-Wippermann M, Rieger A, Metzner M, Knubben-Schweizer G, Reichmann F, Feist M","pdf":{"path":"http:\/\/data\/BMTW_AOP_17103_Tschoner_onl300.pdf","title":"BMTW_AOP_17103_Tschoner","description":"Course of plasma substance P concentrations during umbilical surgery in calves"},"authors":[{"firstName":"T","middleName":"","lastName":"Tschoner"},{"firstName":"M","middleName":"","lastName":"Behrendt-Wippermann"},{"firstName":"A","middleName":"","lastName":"Rieger"},{"firstName":"M","middleName":"","lastName":"Metzner"},{"firstName":"G","middleName":"","lastName":"Knubben-Schweizer"},{"firstName":"F","middleName":"","lastName":"Reichmann"},{"firstName":"M","middleName":"","lastName":"Feist"}],"contentOptimised":"

Summary<\/strong>
The objective of this orientating study was to describe plasma concentrations of substance P in calves undergoing umbilical surgery with two different analgesic protocols. The study was conducted as a randomized controlled double blinded trial. Ten calves (aged 39 \u00b1 10 days) were treated with meloxicam (CON) for analgesia, and 11 calves (aged 37 \u00b1 8 days) with meloxicam and metamizole (MET). Umbilical surgery under general anaesthesia was performed according to a strictly standardized protocol. Blood samples were taken at the day of surgery (one hour before and 5, 15, 30, 45, 60, 90, 150 and 510 minutes after skin incision). Plasma concentrations and AUC of substance P were determined. Plasma substance P increased during umbilical surgery in both groups. In CON, there was a significant difference to plasma substance P baseline concentration 5, 30 and 90 minutes after skin incision. Plasma substance P concentrations were lower in MET compared with CON at all times, and did not differ significantly from baseline concentration. Even though there was no significant difference in the plasma substance P concentrations in-between the groups, the results show that after the administration of metamizole additionally to meloxicam, plasma substance P concentrations in MET were lower than in CON at all times. This fact could indicate that substance P might be a suitable biomarker for nociception and pain. Further studies are needed to confirm this hypothesis.<\/p>

Keywords:<\/strong>
cattle, pain, analgesia, metamizole, meloxicam<\/p>

Zusammenfassung<\/strong>
Das Ziel dieser orientierenden Studie war es, den Substanz P Gehalt im Blutplasma von K\u00e4lbern vor, w\u00e4hrend und nach einer Nabelbruchoperation zu bestimmen. Die K\u00e4lber wurden mit zwei verschiedenen Analgesieprotokollen behandelt. Die Studie war doppelt verblindet. Zehn K\u00e4lber (39 \u00b1 10 Tage alt) der Gruppe CON erhielten Meloxicam, elf K\u00e4lber der Gruppe MET (37 \u00b1 8 Tage alt) Meloxicam und Metamizol. Die Nabeloperation wurde gem\u00e4\u00df einem standardisierten Protokoll unter Allgemeinan\u00e4sthesie durchgef\u00fchrt. Blutproben wurden am Tag der Operation (eine Stunde vorher (Basiskonzentration) und 5, 15, 30, 45, 60, 90, 150 und 510 Minuten nach dem Hautschnitt) genommen. Plasma-Konzentrationen und die AUC von Substanz P wurden ermittelt. Substanz P Konzentrationen stiegen w\u00e4hrend der Operation in beiden Gruppen an. In der CON-Gruppe zeigte sich ein signifikanter Unterschied zur Basiskonzentration zu den Zeitpunkten 5, 30 und 90 Minuten nach dem Hautschnitt. In der MET-Gruppe waren die Substanz P Konzentrationen zu allen Messzeitpunkten niedriger als in der CON-Gruppe, jedoch zu keinem Zeitpunkt signifikant. Die Applikation von Metamizol als Add-on zus\u00e4tzlich zu Meloxicam f\u00fchrte zu einem geringeren Anstieg von Substanz P zu allen Zeitpunkten w\u00e4hrend und nach der Operation. Diese Tatsache k\u00f6nnte ein Hinweis darauf sein, dass Substanz P ein geeigneter Biomarker zur Objektivierung von Nociception beim Kalb sein k\u00f6nnte. Zuk\u00fcnftige, weitere Studien sind n\u00f6tig um diese Hypothese zu untermauern. Der positive analgetische Effekt von Metamizol ist bei Nabeloperationen zu empfehlen.<\/p>

Schl\u00fcsselw\u00f6rter:<\/strong>
Rind, Schmerz, Analgesie, Metamizol, Meloxicam<\/p>","primaryLanguage":"englisch","summary":"The objective of this orientating study was to describe plasma concentrations of substance P in calves undergoing umbilical surgery with two different analgesic protocols. The study was conducted as a randomized controlled double blinded trial. Ten calves (aged 39 \u00b1 10 days) were treated with meloxicam (CON) for analgesia, and 11 calves (aged 37 \u00b1 8 days) with meloxicam and metamizole (MET). Umbilical surgery under general anaesthesia was performed according to a strictly standardized protocol. Blood samples were taken at the day of surgery (one hour before and 5, 15, 30, 45, 60, 90, 150 and 510 minutes after skin incision). Plasma concentrations and AUC of substance P were determined. Plasma substance P increased during umbilical surgery in both groups. In CON, there was a significant difference to plasma substance P baseline concentration 5, 30 and 90 minutes after skin incision. Plasma substance P concentrations were lower in MET compared with CON at all times, and did not differ significantly from baseline concentration. Even though there was no significant difference in the plasma substance P concentrations in-between the groups, the results show that after the administration of metamizole additionally to meloxicam, plasma substance P concentrations in MET were lower than in CON at all times. This fact could indicate that substance P might be a suitable biomarker for nociception and pain. Further studies are needed to confirm this hypothesis.<\/p>

","keywords":["cattle","pain","analgesia","metamizole","meloxicam"],"zusammenfassung":"Das Ziel dieser orientierenden Studie war es, den Substanz P Gehalt im Blutplasma von K\u00e4lbern vor, w\u00e4hrend und nach einer Nabelbruchoperation zu bestimmen. Die K\u00e4lber wurden mit zwei verschiedenen Analgesieprotokollen behandelt. Die Studie war doppelt verblindet. Zehn K\u00e4lber (39 \u00b1 10 Tage alt) der Gruppe CON erhielten Meloxicam, elf K\u00e4lber der Gruppe MET (37 \u00b1 8 Tage alt) Meloxicam und Metamizol. Die Nabeloperation wurde gem\u00e4\u00df einem standardisierten Protokoll unter Allgemeinan\u00e4sthesie durchgef\u00fchrt. Blutproben wurden am Tag der Operation (eine Stunde vorher (Basiskonzentration) und 5, 15, 30, 45, 60, 90, 150 und 510 Minuten nach dem Hautschnitt) genommen. Plasma-Konzentrationen und die AUC von Substanz P wurden ermittelt. Substanz P Konzentrationen stiegen w\u00e4hrend der Operation in beiden Gruppen an. In der CON-Gruppe zeigte sich ein signifikanter Unterschied zur Basiskonzentration zu den Zeitpunkten 5, 30 und 90 Minuten nach dem Hautschnitt. In der MET-Gruppe waren die Substanz P Konzentrationen zu allen Messzeitpunkten niedriger als in der CON-Gruppe, jedoch zu keinem Zeitpunkt signifikant. Die Applikation von Metamizol als Add-on zus\u00e4tzlich zu Meloxicam f\u00fchrte zu einem geringeren Anstieg von Substanz P zu allen Zeitpunkten w\u00e4hrend und nach der Operation. Diese Tatsache k\u00f6nnte ein Hinweis darauf sein, dass Substanz P ein geeigneter Biomarker zur Objektivierung von Nociception beim Kalb sein k\u00f6nnte. Zuk\u00fcnftige, weitere Studien sind n\u00f6tig um diese Hypothese zu untermauern. Der positive analgetische Effekt von Metamizol ist bei Nabeloperationen zu empfehlen.<\/p>

","schluesselwoerter":["Rind","Schmerz","Analgesie","Metamizol","Meloxicam"],"translatedTitle":"Verlauf von Substanz P Konzentrationen im Blutplasma w\u00e4hrend einer Nabeloperation bei K\u00e4lbern","abstractE":"The objective of this orientating study was to describe plasma concentrations of substance P in calves undergoing umbilical surgery with two different analgesic protocols. The study was conducted as a randomized controlled double blinded trial. Ten calves (aged 39 \u00b1 10 days) were treated with meloxicam (CON) for analgesia, and 11 calves (aged 37 \u00b1 8 days) with meloxicam and metamizole (MET). Umbilical surgery under general anaesthesia was performed according to a strictly standardized protocol. Blood samples were taken at the day of surgery (one hour before and 5, 15, 30, 45, 60, 90, 150 and 510 minutes after skin incision). Plasma concentrations and AUC of substance P were determined. Plasma substance P increased during umbilical surgery in both groups. In CON, there was a significant difference to plasma substance P baseline concentration 5, 30 and 90 minutes after skin incision. Plasma substance P concentrations were lower in MET compared with CON at all times, and did not differ significantly from baseline concentration. Even though there was no significant difference in the plasma substance P concentrations in-between the groups, the results show that after the administration of metamizole additionally to meloxicam, plasma substance P concentrations in MET were lower than in CON at all times. This fact could indicate that substance P might be a suitable biomarker for nociception and pain. Further studies are needed to confirm this hypothesis.","date":{"year":2018,"date":"04\/2018","accepted":"2018-04-26"},"volume":131,"openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"","redirects":["course-of-plasma-substance-p-concentrations-during-umbilical-surgery-in-calves\/150\/3130\/107787"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} %8 04/2018