%0 Journal Article %K antibiotics %K consumption %K animals %K drug monitoring %K critically important antimicrobials %B Berliner und Münchener Tierärztliche Wochenschrift %C Hannover %D 2014 %G English %I Schlütersche Verlagsgesellschaft mbH & Co. KG %P 359-365 %R 10.2376/0005-9366-127-359 %T Analysis of the distribution of veterinary antimicrobial products to veterinarians in Germany in 2011 and 2012 %V 127 %1 {"oldId":82177,"title":"Analysis of the distribution of veterinary antimicrobial products to veterinarians in Germany in 2011 and 2012","topline":"Open Access BMTW | Themenheft Antibiotikaresistenzen","teaserText":"Auswertung der Abgabemengen veterin\u00e4rmedizinischer Antibiotika an Tier\u00e4rzte in Deutschland 2011 und 2012","content":"

Summary<\/span>
For the implementation of risk management measures against the development and spread of antimicrobial resistances it is important to gain a quantitative insight into the use of veterinary antimicrobial agents. Since 2011, all pharmaceutical companies and wholesalers in Germany are required to report their sales data of veterinary antimicrobial products (VAPs). In 2011, 1706 t of antimicrobially active substances were sold to veterinarians registered in Germany, in 2012 the amount decreased to 1619 t. Tetracyclines and penicillins had the largest shares in both years, followed by sulfonamides, macrolides and polypeptides. Amoxicillin alone accounted for more than a quarter of the total amounts of all sold antimicrobials. In regard to AMR it is most important to limit the use of critically important antimicrobials, namely fluoroquinolones and 3rd and 4th generation cephalosporins. While in both years these groups accounted for less than 1% of the amount of sold antimicrobials, this does not reflect adequately their use, since they are used in much lower doses. Furthermore, it is worrying that the sales of fluoroquinolones and 3rd generation cephalosporins increased by 26% and 14%, respectively, between 2011 and 2012, while the sales of 4th generation cephalosporins decreased only by 2%. More than 95% of the active substances were contained in VAPs intended for oral application; only fluoroquinolones, 3rd and 4th generation cephalosporins as well as fenicols were primarily or even exclusively applied by injection. <\/p>

Keywords<\/span>
antibiotics, consumption, animals, drug monitoring, critically important antimicrobials <\/p>

Zusammenfassung<\/span>
Um Ma\u00dfnahmen f\u00fcr das Risikomanagement gegen die Entwicklung und Ausbreitung von Antibiotikaresistenzen zu ergreifen, sind u. a. auch Kenntnisse \u00fcber die Mengen angewandter Antibiotika in der Veterin\u00e4rmedizin notwendig. Seit 2011 m\u00fcssen alle pharmazeutischen Unternehmen und Gro\u00dfh\u00e4ndler in Deutschland ihre Abgabemengen an veterin\u00e4rmedizinischen Antibiotika an Tier\u00e4rzte melden. Im Jahr 2011 wurden 1706 t antibiotisch wirksamer Substanzen an Tier\u00e4rzte in Deutschland abgegeben, 2012 war es eine Menge von 1619 t. Tetracycline und Penicilline hatten in beiden Jahren den gr\u00f6\u00dften Anteil, gefolgt von Sulfonamiden, Makroliden und Polypeptiden. Ein Viertel der gesamten Menge entfiel dabei alleine auf Amoxicillin. Im Hinblick auf die Antibiotikaresistenz ist es besonders wichtig, den Einsatz der \u201ccritically important antimicrobials\u201c, vor allem Fluorchinolone und Cephalosporine der 3. und 4. Generation, zu minimieren. Der Anteil dieser Klassen lag in beiden Jahren unter 1 % der Gesamtabgabemengen. Dies spiegelt jedoch nur unzureichend ihren Einsatz wider, da sie in wesentlich geringerer Dosierung eingesetzt werden als \u00e4ltere Wirkstoffe. Au\u00dferdem ist es durchaus interessant, dass die Abgabemengen von Fluorchinolonen und Cephalosporinen der 3. Generation zwischen 2011 und 2012 um 26 % bzw. 14 % zunahmen, w\u00e4hrend die Abgabemengen von Cephalosporinen der 4. Generation nur um 2 % abnahmen. Mehr als 95 % der Wirkstoffe wurden in Pr\u00e4paraten f\u00fcr die orale Applikation abgegeben, nur Fluorchinolone und Cephalosporine der 3. und 4. Generation sowie Fenicole waren \u00fcberwiegend oder ausschlie\u00dflich in Pr\u00e4paraten zur parenteralen Verabreichung enthalten. <\/p>

Schl\u00fcsselw\u00f6rter<\/span>
Antibiotika, Verbrauch, Tiere, Arzneimittel\u00fcberwachung, critically important antimicrobials<\/p>","categories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"],"fromDate":"Oct 1, 2014 8:14:55 PM","oldUrls":["http:\/\/vetline.de\/analysis-of-the-distribution-of-veterinary-antimicrobial-products-to-veterinarians-in-germany-in-2011-and-2012\/150\/3130\/82177","http:\/\/vetline.de\/analysis-of-the-distribution-of-veterinary-antimicrobial-products-to-veterinarians-in-germany-in-2011-and-2012\/150\/3216\/82177"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","doiDocumentUri":"http:\/\/www.vetline.de\/analysis-of-the-distribution-of-veterinary-antimicrobial-products-to-veterinarians-in-germany-in-2011-and-2012\/150\/3130\/82177\/","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr 127, 359\u2013365 (2014)","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-127-359","doiFirstPage":"359","doiLastPage":"365","doiTransmitted":true,"doiAuthor":"Hauck R, R\u00f6mer A, Reimer I, Bender A, Haas C, Heberer T, Wallmann J","pdf":{"path":"http:\/\/data\/BMW_2014_09_10_0359_onl300.pdf","title":"BMW_2014_09_10_0359.pdf","description":"Analysis of the distribution of veterinary antimicrobial products to veterinarians in Germany in 2011 and 2012 "},"authors":[{"firstName":"R","middleName":"","lastName":"Hauck"},{"firstName":"A","middleName":"","lastName":"R\u00f6mer"},{"firstName":"I","middleName":"","lastName":"Reimer"},{"firstName":"A","middleName":"","lastName":"Bender"},{"firstName":"C","middleName":"","lastName":"Haas"},{"firstName":"T","middleName":"","lastName":"Heberer"},{"firstName":"J","middleName":"","lastName":"Wallmann"}],"contentOptimised":"

Summary<\/strong>
For the implementation of risk management measures against the development and spread of antimicrobial resistances it is important to gain a quantitative insight into the use of veterinary antimicrobial agents. Since 2011, all pharmaceutical companies and wholesalers in Germany are required to report their sales data of veterinary antimicrobial products (VAPs). In 2011, 1706 t of antimicrobially active substances were sold to veterinarians registered in Germany, in 2012 the amount decreased to 1619 t. Tetracyclines and penicillins had the largest shares in both years, followed by sulfonamides, macrolides and polypeptides. Amoxicillin alone accounted for more than a quarter of the total amounts of all sold antimicrobials. In regard to AMR it is most important to limit the use of critically important antimicrobials, namely fluoroquinolones and 3rd and 4th generation cephalosporins. While in both years these groups accounted for less than 1% of the amount of sold antimicrobials, this does not reflect adequately their use, since they are used in much lower doses. Furthermore, it is worrying that the sales of fluoroquinolones and 3rd generation cephalosporins increased by 26% and 14%, respectively, between 2011 and 2012, while the sales of 4th generation cephalosporins decreased only by 2%. More than 95% of the active substances were contained in VAPs intended for oral application; only fluoroquinolones, 3rd and 4th generation cephalosporins as well as fenicols were primarily or even exclusively applied by injection. <\/p>

Keywords:<\/strong>
antibiotics, consumption, animals, drug monitoring, critically important antimicrobials <\/p>

Zusammenfassung<\/strong>
Um Ma\u00dfnahmen f\u00fcr das Risikomanagement gegen die Entwicklung und Ausbreitung von Antibiotikaresistenzen zu ergreifen, sind u. a. auch Kenntnisse \u00fcber die Mengen angewandter Antibiotika in der Veterin\u00e4rmedizin notwendig. Seit 2011 m\u00fcssen alle pharmazeutischen Unternehmen und Gro\u00dfh\u00e4ndler in Deutschland ihre Abgabemengen an veterin\u00e4rmedizinischen Antibiotika an Tier\u00e4rzte melden. Im Jahr 2011 wurden 1706 t antibiotisch wirksamer Substanzen an Tier\u00e4rzte in Deutschland abgegeben, 2012 war es eine Menge von 1619 t. Tetracycline und Penicilline hatten in beiden Jahren den gr\u00f6\u00dften Anteil, gefolgt von Sulfonamiden, Makroliden und Polypeptiden. Ein Viertel der gesamten Menge entfiel dabei alleine auf Amoxicillin. Im Hinblick auf die Antibiotikaresistenz ist es besonders wichtig, den Einsatz der \u201ccritically important antimicrobials\u201c, vor allem Fluorchinolone und Cephalosporine der 3. und 4. Generation, zu minimieren. Der Anteil dieser Klassen lag in beiden Jahren unter 1 % der Gesamtabgabemengen. Dies spiegelt jedoch nur unzureichend ihren Einsatz wider, da sie in wesentlich geringerer Dosierung eingesetzt werden als \u00e4ltere Wirkstoffe. Au\u00dferdem ist es durchaus interessant, dass die Abgabemengen von Fluorchinolonen und Cephalosporinen der 3. Generation zwischen 2011 und 2012 um 26 % bzw. 14 % zunahmen, w\u00e4hrend die Abgabemengen von Cephalosporinen der 4. Generation nur um 2 % abnahmen. Mehr als 95 % der Wirkstoffe wurden in Pr\u00e4paraten f\u00fcr die orale Applikation abgegeben, nur Fluorchinolone und Cephalosporine der 3. und 4. Generation sowie Fenicole waren \u00fcberwiegend oder ausschlie\u00dflich in Pr\u00e4paraten zur parenteralen Verabreichung enthalten. <\/p>

Schl\u00fcsselw\u00f6rter:<\/strong>
Antibiotika, Verbrauch, Tiere, Arzneimittel\u00fcberwachung, critically important antimicrobials<\/p>","primaryLanguage":"englisch","summary":"For the implementation of risk management measures against the development and spread of antimicrobial resistances it is important to gain a quantitative insight into the use of veterinary antimicrobial agents. Since 2011, all pharmaceutical companies and wholesalers in Germany are required to report their sales data of veterinary antimicrobial products (VAPs). In 2011, 1706 t of antimicrobially active substances were sold to veterinarians registered in Germany, in 2012 the amount decreased to 1619 t. Tetracyclines and penicillins had the largest shares in both years, followed by sulfonamides, macrolides and polypeptides. Amoxicillin alone accounted for more than a quarter of the total amounts of all sold antimicrobials. In regard to AMR it is most important to limit the use of critically important antimicrobials, namely fluoroquinolones and 3rd and 4th generation cephalosporins. While in both years these groups accounted for less than 1% of the amount of sold antimicrobials, this does not reflect adequately their use, since they are used in much lower doses. Furthermore, it is worrying that the sales of fluoroquinolones and 3rd generation cephalosporins increased by 26% and 14%, respectively, between 2011 and 2012, while the sales of 4th generation cephalosporins decreased only by 2%. More than 95% of the active substances were contained in VAPs intended for oral application; only fluoroquinolones, 3rd and 4th generation cephalosporins as well as fenicols were primarily or even exclusively applied by injection. <\/p>

","keywords":["antibiotics","consumption","animals","drug monitoring","critically important antimicrobials"],"zusammenfassung":"Um Ma\u00dfnahmen f\u00fcr das Risikomanagement gegen die Entwicklung und Ausbreitung von Antibiotikaresistenzen zu ergreifen, sind u. a. auch Kenntnisse \u00fcber die Mengen angewandter Antibiotika in der Veterin\u00e4rmedizin notwendig. Seit 2011 m\u00fcssen alle pharmazeutischen Unternehmen und Gro\u00dfh\u00e4ndler in Deutschland ihre Abgabemengen an veterin\u00e4rmedizinischen Antibiotika an Tier\u00e4rzte melden. Im Jahr 2011 wurden 1706 t antibiotisch wirksamer Substanzen an Tier\u00e4rzte in Deutschland abgegeben, 2012 war es eine Menge von 1619 t. Tetracycline und Penicilline hatten in beiden Jahren den gr\u00f6\u00dften Anteil, gefolgt von Sulfonamiden, Makroliden und Polypeptiden. Ein Viertel der gesamten Menge entfiel dabei alleine auf Amoxicillin. Im Hinblick auf die Antibiotikaresistenz ist es besonders wichtig, den Einsatz der \u201ccritically important antimicrobials\u201c, vor allem Fluorchinolone und Cephalosporine der 3. und 4. Generation, zu minimieren. Der Anteil dieser Klassen lag in beiden Jahren unter 1 % der Gesamtabgabemengen. Dies spiegelt jedoch nur unzureichend ihren Einsatz wider, da sie in wesentlich geringerer Dosierung eingesetzt werden als \u00e4ltere Wirkstoffe. Au\u00dferdem ist es durchaus interessant, dass die Abgabemengen von Fluorchinolonen und Cephalosporinen der 3. Generation zwischen 2011 und 2012 um 26 % bzw. 14 % zunahmen, w\u00e4hrend die Abgabemengen von Cephalosporinen der 4. Generation nur um 2 % abnahmen. Mehr als 95 % der Wirkstoffe wurden in Pr\u00e4paraten f\u00fcr die orale Applikation abgegeben, nur Fluorchinolone und Cephalosporine der 3. und 4. Generation sowie Fenicole waren \u00fcberwiegend oder ausschlie\u00dflich in Pr\u00e4paraten zur parenteralen Verabreichung enthalten. <\/p>

","schluesselwoerter":["Antibiotika","Verbrauch","Tiere","Arzneimittel\u00fcberwachung","critically important antimicrobials"],"translatedTitle":"Auswertung der Abgabemengen veterin\u00e4rmedizinischer Antibiotika an Tier\u00e4rzte in Deutschland 2011 und 2012","abstractE":"For the implementation of risk management measures against the development and spread of antimicrobial resistances it is important to gain a quantitative insight into the use of veterinary antimicrobial agents. Since 2011, all pharmaceutical companies and wholesalers in Germany are required to report their sales data of veterinary antimicrobial products (VAPs). In 2011, 1706 t of antimicrobially active substances were sold to veterinarians registered in Germany, in 2012 the amount decreased to 1619 t. Tetracyclines and penicillins had the largest shares in both years, followed by sulfonamides, macrolides and polypeptides. Amoxicillin alone accounted for more than a quarter of the total amounts of all sold antimicrobials. In regard to AMR it is most important to limit the use of critically important antimicrobials, namely fluoroquinolones and 3rd and 4th generation cephalosporins. While in both years these groups accounted for less than 1% of the amount of sold antimicrobials, this does not reflect adequately their use, since they are used in much lower doses. Furthermore, it is worrying that the sales of fluoroquinolones and 3rd generation cephalosporins increased by 26% and 14%, respectively, between 2011 and 2012, while the sales of 4th generation cephalosporins decreased only by 2%. More than 95% of the active substances were contained in VAPs intended for oral application; only fluoroquinolones, 3rd and 4th generation cephalosporins as well as fenicols were primarily or even exclusively applied by injection. ","date":{"year":2014,"date":"10\/2014","accepted":"2014-10-01"},"volume":"127","openAccess":true,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"359-365","redirects":["analysis-of-the-distribution-of-veterinary-antimicrobial-products-to-veterinarians-in-germany-in-2011-and-2012\/150\/3130\/82177","analysis-of-the-distribution-of-veterinary-antimicrobial-products-to-veterinarians-in-germany-in-2011-and-2012\/150\/3216\/82177"],"tierartCategories":[],"artikelartCategories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"]} %8 10/2014