TY - JOUR
KW - Female genital tract
KW - vaginal leiomyoma
KW - vagina polyp
KW - cervical gland neoplasia
KW - decidual cell proliferation
AU - C Bertram
AU - R Klopfleisch
AU - N Erickson
AU - K Müller
AB - Pathological changes affecting the female reproductive tract in guinea pigs have been described previously in the literature. However, knowledge about the clinical findings and management of uterine and vaginal proliferative diseases has been sparse to date. In dogs, a common clinical presentation of various types of uterine and vaginal abnormalities is a tumor-like mass protruding from the vaginal orifice. In the present study, we investigated the frequency and underlying causes of masses protruding from the vaginal orifice as the reason for presentation in guinea pigs. A retrospective analysis of pathological and associated clinical records of a total of 723 intact female guinea pigs identified masses protruding from the vaginal orifice in 12 animals (1.7%). Of these, six originated from the vagina – four vaginal leiomyomas and two non-neoplastic vaginal polyps– and six from the uterus – two cervical gland neoplasms, two decidual cell proliferations, and two uterine prolapses. Additionally, four cases of decidual cell proliferations being discharged from the uterus and subsequently found in the animal’s cage were identified. All six vaginal masses were successfully removed by simple ligation through the vaginal opening. The resection of three uterine masses by simple ligation resulted in an incomplete surgical removal. In conclusion, differential diagnoses for vulvar masses in guinea pigs should include vaginal or uterine neoplastic or non-neoplastic proliferative disorders. Knowledge of the anatomical origin and type of disease is essential for the therapeutic management. Most notably, although decidual cell proliferations are thought to regress spontaneously, they may also be associated with uterine neoplasia and so necessitate a thorough clinical examination of the uterus. 
BT - Kleintierpraxis
CY - Hannover
DA - 01/2020
DO - 10.2377/0023-2076-65-4
ET - 1
LA - German
N2 - Pathological changes affecting the female reproductive tract in guinea pigs have been described previously in the literature. However, knowledge about the clinical findings and management of uterine and vaginal proliferative diseases has been sparse to date. In dogs, a common clinical presentation of various types of uterine and vaginal abnormalities is a tumor-like mass protruding from the vaginal orifice. In the present study, we investigated the frequency and underlying causes of masses protruding from the vaginal orifice as the reason for presentation in guinea pigs. A retrospective analysis of pathological and associated clinical records of a total of 723 intact female guinea pigs identified masses protruding from the vaginal orifice in 12 animals (1.7%). Of these, six originated from the vagina – four vaginal leiomyomas and two non-neoplastic vaginal polyps– and six from the uterus – two cervical gland neoplasms, two decidual cell proliferations, and two uterine prolapses. Additionally, four cases of decidual cell proliferations being discharged from the uterus and subsequently found in the animal’s cage were identified. All six vaginal masses were successfully removed by simple ligation through the vaginal opening. The resection of three uterine masses by simple ligation resulted in an incomplete surgical removal. In conclusion, differential diagnoses for vulvar masses in guinea pigs should include vaginal or uterine neoplastic or non-neoplastic proliferative disorders. Knowledge of the anatomical origin and type of disease is essential for the therapeutic management. Most notably, although decidual cell proliferations are thought to regress spontaneously, they may also be associated with uterine neoplasia and so necessitate a thorough clinical examination of the uterus. 
PB - M. & H. Schaper GmbH
PP - Hannover
PY - 2020
EP - 4–11
T1 - Genital tract masses protruding from the vaginal orifice of female pet guinea pigs (Cavia porcellus): Differential diagnosis and treatment 
T2 - Kleintierpraxis
TI - Genital tract masses protruding from the vaginal orifice of female pet guinea pigs (Cavia porcellus): Differential diagnosis and treatment 
TT - Prolaps von Umfangsvermehrungen des Geschlechtstrakts aus der Vaginalöffnung als Vorstellungsgrund weiblicher Meerschweinchen (Cavia porcellus)
VL - 65
SN - 0023-2076
ER -