TY - JOUR KW - S. aureus KW - MRSA KW - zoonosis KW - MedVet-Staph AU - R Köck AU - B Ballhausen AU - M Bischoff AU - C Cuny AU - T Eckmanns AU - A Fetsch AU - D Harmsen AU - T Goerge AU - B Oberheitmann AU - S Schwarz AU - T Selhorst AU - B-A Tenhagen AU - B Walther AU - W Witte AU - W Ziebuhr AU - K Becker AB - Methicillin-resistant Staphylococcus aureus (MRSA) causes colonization and infection both in animals and humans. In Germany, cases of MRSA colonization among humans, w+hich affect 0.5–1.5% of the general population and 1.0–2.5% of patients at hospital admission, are still mostly associated with previous healthcare contact and defined epidemic clonal lineages. However, MRSA is also distributed in livestock production in Germany, mostly without causing infections in the animals. These MRSA predominantly belong to the clonal complex (CC) 398, but also to CC9 and CC97. Zoonotic transmission of MRSA CC398 from livestock to humans occurs predominantly in people with occupational livestock contact. Spread of MRSA CC398 to household members of these persons is also frequently observed, but dissemination in the general population is limited so far. However, especially in areas with intensive livestock husbandry, about 20–38% of MRSA CC398 cases among humans cannot be epidemiologically linked to direct livestock contact, indicating other transmission pathways. MRSA CC398 currently causes about 2% of all human MRSA infections (wound infections, pneumonia, sepsis) in Germany, but up to 10% in regions characterized by a high density of livestock-farming. The burden of MRSA in companion animals was demonstrated to range between 3.6–9.4% within wound samples obtained from dogs, cats and horses, respectively. In contrast to livestock and horses, MRSA distributed in pet animals are mostly associated with MRSA clonal lineages that are also prevalent in human healthcare facilities. Overall, zoonotic exchange of MRSA between humans and animals has relevant impact on the epidemiology of MRSA in Germany. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":81235,"title":"The impact of zoonotic MRSA colonization and infection in Germany","topline":"Open Access BMTW | Themenheft Antibiotikaresistenzen","teaserText":"MRSA als Erreger von Zoonosen in Deutschland","content":"

Summary<\/span>
Methicillin-resistant Staphylococcus aureus (MRSA) causes colonization and infection both in animals and humans. In Germany, cases of MRSA colonization among humans, w+hich affect 0.5\u20131.5% of the general population and 1.0\u20132.5% of patients at hospital admission, are still mostly associated with previous healthcare contact and defined epidemic clonal lineages. However, MRSA is also distributed in livestock production in Germany, mostly without causing infections in the animals. These MRSA predominantly belong to the clonal complex (CC) 398, but also to CC9 and CC97. Zoonotic transmission of MRSA CC398 from livestock to humans occurs predominantly in people with occupational livestock contact. Spread of MRSA CC398 to household members of these persons is also frequently observed, but dissemination in the general population is limited so far. However, especially in areas with intensive livestock husbandry, about 20\u201338% of MRSA CC398 cases among humans cannot be epidemiologically linked to direct livestock contact, indicating other transmission pathways. MRSA CC398 currently causes about 2% of all human MRSA infections (wound infections, pneumonia, sepsis) in Germany, but up to 10% in regions characterized by a high density of livestock-farming. The burden of MRSA in companion animals was demonstrated to range between 3.6\u20139.4% within wound samples obtained from dogs, cats and horses, respectively. In contrast to livestock and horses, MRSA distributed in pet animals are mostly associated with MRSA clonal lineages that are also prevalent in human healthcare facilities. Overall, zoonotic exchange of MRSA between humans and animals has relevant impact on the epidemiology of MRSA in
Germany.<\/p>

Keywords:<\/span> S. aureus, MRSA, zoonosis, MedVet-Staph<\/p>

Zusammenfassung<\/span>
Methicillin-resistente Staphylococcus aureus (MRSA) verursachen Besiedlungen und Infektionen bei Menschen und Tieren. In Deutschland ist die Mehrzahl der MRSA-F\u00e4lle beim Menschen, die 0,5\u20131,5 % der Allgemeinbev\u00f6lkerung und 1,0\u20132,5 % der Patienten bei Krankenhausaufnahme betreffen, mit vorhergehendem Kontakt zu Einrichtungen des Gesundheitswesens assoziiert. Meist handelt es sich um Besiedlungen durch definierte, epidemisch auftretende MRSA-Genotypen. Zugleich wird MRSA jedoch verbreitet in der landwirtschaftlichen Nutztierhaltung gefunden, meist ohne Infektionen bei den Tieren auszul\u00f6sen. Unter diesen Nutztier-assoziieren MRSA \u00fcberwiegt der klonale Komplex (CC) 398 neben CC9 und CC97. Zoonotische \u00dcbertragungen von MRSA CC398 f\u00fchren zur nasalen Besiedlung von Berufsgruppen mit Nutztierkontakt und deren Haushaltsmitgliedern. Die Verbreitung von MRSA CC398 in der Allgemeinbev\u00f6lkerung ohne Tierkontakt ist bisher eingeschr\u00e4nkt; jedoch k\u00f6nnen, insbesondere in l\u00e4ndlichen Regionen, ca. 20\u201338 % der F\u00e4lle von MRSA CC398 bei Menschen nicht auf einen (in-)direkten Tierkontakt zur\u00fcckgef\u00fchrt werden, was auf andere Transmissionswege hindeutet. MRSA CC398 verursacht derzeit etwa 2 % aller humanen MRSA- Infektionen (Wundinfektion, Pneumonie, Sepsis) in Deutschland, jedoch bis zu 10 % in Regionen mit hoher Tierhaltungsdichte. Bei Hunden, Katzen und Pfer\u00adden werden zwischen 3,6 und 9,4 % der Wundinfektionen durch MRSA ausgel\u00f6st. Anders als bei Nutztieren und Pferden sind die bei kleinen Haustieren gefundenen MRSA aber \u00fcberwiegend identisch zu klonalen Linien, die auch in huma\u00adnen Gesundheitseinrichtungen gefunden werden. Insgesamt wird zunehmend deutlich, dass der zoonotische Austausch von MRSA zwischen Mensch und Tier einen wichtigen Einfluss auf die Epidemiologie von MRSA in Deutschland aus\u00fcbt.<\/p>

Schl\u00fcsselw\u00f6rter:<\/span> S. aureus, MRSA, Zoonose, MedVet-Staph<\/p>","categories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"],"fromDate":"Sep 17, 2014 7:46:47 AM","oldUrls":["http:\/\/vetline.de\/the-impact-of-zoonotic-mrsa-colonization-and-infection-in-germany\/150\/3130\/81235","http:\/\/vetline.de\/the-impact-of-zoonotic-mrsa-colonization-and-infection-in-germany\/150\/3216\/81235"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","doiDocumentUri":"http:\/\/cf01.vetline.schluetersche.de\/files\/smfiledata\/3\/9\/8\/3\/3\/5\/2_OA_14009_Koeck.pdf","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr 127","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-127-384","doiFirstPage":"384","doiLastPage":"398","doiTransmitted":true,"doiAuthor":"K\u00f6ck R, Ballhausen B, Bischoff M, Cuny CH, Eckmanns T, Fetsch A, Harmsen D, Goerge T, Oberheitmann B, Schwarz S, Selhorst T, Tenhagen BA, Walther B, Witte W, Ziebuhr W, Becker K","pdf":{"path":"http:\/\/data\/BMW_2014_09_10_0384_onl300.pdf","title":"The impact of zoonotic MRSA colonization and infection in Germany","description":"Methicillin-resistant Staphylococcus aureus (MRSA) causes colonization and\r\ninfection both in animals and humans. In Germany, cases of MRSA colonization\r\namong humans, w+hich affect 0.5\u20131.5% of the general population and 1.0\u20132.5%\r\nof patients at hospital admission, are still mostly associated with previous\r\nhealthcare contact and defined epidemic clonal lineages. However, MRSA is also\r\ndistributed in livestock production in Germany, mostly without causing infections\r\nin the animals. These MRSA predominantly belong to the clonal complex\r\n(CC) 398, but also to CC9 and CC97. Zoonotic transmission of MRSA CC398 from\r\nlivestock to humans occurs predominantly in people with occupational livestock\r\ncontact. Spread of MRSA CC398 to household members of these persons is also\r\nfrequently observed, but dissemination in the general population is limited so far.\r\nHowever, especially in areas with intensive livestock husbandry, about 20\u201338% of\r\nMRSA CC398 cases among humans cannot be epidemiologically linked to direct\r\nlivestock contact, indicating other transmission pathways. MRSA CC398 currently\r\ncauses about 2% of all human MRSA infections (wound infections, pneumonia,\r\nsepsis) in Germany, but up to 10% in regions characterized by a high density of\r\nlivestock-farming. The burden of MRSA in companion animals was demonstrated\r\nto range between 3.6\u20139.4% within wound samples obtained from dogs, cats and\r\nhorses, respectively. In contrast to livestock and horses, MRSA distributed in\r\npet animals are mostly associated with MRSA clonal lineages that are also prevalent\r\nin human healthcare facilities. Overall, zoonotic exchange of MRSA between\r\nhumans and animals"},"authors":[{"firstName":"R","middleName":"","lastName":"K\u00f6ck"},{"firstName":"B","middleName":"","lastName":"Ballhausen"},{"firstName":"M","middleName":"","lastName":"Bischoff"},{"firstName":"C","middleName":"H","lastName":"Cuny"},{"firstName":"T","middleName":"","lastName":"Eckmanns"},{"firstName":"A","middleName":"","lastName":"Fetsch"},{"firstName":"D","middleName":"","lastName":"Harmsen"},{"firstName":"T","middleName":"","lastName":"Goerge"},{"firstName":"B","middleName":"","lastName":"Oberheitmann"},{"firstName":"S","middleName":"","lastName":"Schwarz"},{"firstName":"T","middleName":"","lastName":"Selhorst"},{"firstName":"B","middleName":"A","lastName":"Tenhagen"},{"firstName":"B","middleName":"","lastName":"Walther"},{"firstName":"W","middleName":"","lastName":"Witte"},{"firstName":"W","middleName":"","lastName":"Ziebuhr"},{"firstName":"K","middleName":"","lastName":"Becker"}],"contentOptimised":"

Summary<\/strong>
Methicillin-resistant Staphylococcus aureus (MRSA) causes colonization and infection both in animals and humans. In Germany, cases of MRSA colonization among humans, w+hich affect 0.5\u20131.5% of the general population and 1.0\u20132.5% of patients at hospital admission, are still mostly associated with previous healthcare contact and defined epidemic clonal lineages. However, MRSA is also distributed in livestock production in Germany, mostly without causing infections in the animals. These MRSA predominantly belong to the clonal complex (CC) 398, but also to CC9 and CC97. Zoonotic transmission of MRSA CC398 from livestock to humans occurs predominantly in people with occupational livestock contact. Spread of MRSA CC398 to household members of these persons is also frequently observed, but dissemination in the general population is limited so far. However, especially in areas with intensive livestock husbandry, about 20\u201338% of MRSA CC398 cases among humans cannot be epidemiologically linked to direct livestock contact, indicating other transmission pathways. MRSA CC398 currently causes about 2% of all human MRSA infections (wound infections, pneumonia, sepsis) in Germany, but up to 10% in regions characterized by a high density of livestock-farming. The burden of MRSA in companion animals was demonstrated to range between 3.6\u20139.4% within wound samples obtained from dogs, cats and horses, respectively. In contrast to livestock and horses, MRSA distributed in pet animals are mostly associated with MRSA clonal lineages that are also prevalent in human healthcare facilities. Overall, zoonotic exchange of MRSA between humans and animals has relevant impact on the epidemiology of MRSA in
Germany.<\/p>

Keywords:<\/strong> S. aureus, MRSA, zoonosis, MedVet-Staph<\/p>

Zusammenfassung<\/strong>
Methicillin-resistente Staphylococcus aureus (MRSA) verursachen Besiedlungen und Infektionen bei Menschen und Tieren. In Deutschland ist die Mehrzahl der MRSA-F\u00e4lle beim Menschen, die 0,5\u20131,5 % der Allgemeinbev\u00f6lkerung und 1,0\u20132,5 % der Patienten bei Krankenhausaufnahme betreffen, mit vorhergehendem Kontakt zu Einrichtungen des Gesundheitswesens assoziiert. Meist handelt es sich um Besiedlungen durch definierte, epidemisch auftretende MRSA-Genotypen. Zugleich wird MRSA jedoch verbreitet in der landwirtschaftlichen Nutztierhaltung gefunden, meist ohne Infektionen bei den Tieren auszul\u00f6sen. Unter diesen Nutztier-assoziieren MRSA \u00fcberwiegt der klonale Komplex (CC) 398 neben CC9 und CC97. Zoonotische \u00dcbertragungen von MRSA CC398 f\u00fchren zur nasalen Besiedlung von Berufsgruppen mit Nutztierkontakt und deren Haushaltsmitgliedern. Die Verbreitung von MRSA CC398 in der Allgemeinbev\u00f6lkerung ohne Tierkontakt ist bisher eingeschr\u00e4nkt; jedoch k\u00f6nnen, insbesondere in l\u00e4ndlichen Regionen, ca. 20\u201338 % der F\u00e4lle von MRSA CC398 bei Menschen nicht auf einen (in-)direkten Tierkontakt zur\u00fcckgef\u00fchrt werden, was auf andere Transmissionswege hindeutet. MRSA CC398 verursacht derzeit etwa 2 % aller humanen MRSA- Infektionen (Wundinfektion, Pneumonie, Sepsis) in Deutschland, jedoch bis zu 10 % in Regionen mit hoher Tierhaltungsdichte. Bei Hunden, Katzen und Pfer\u00adden werden zwischen 3,6 und 9,4 % der Wundinfektionen durch MRSA ausgel\u00f6st. Anders als bei Nutztieren und Pferden sind die bei kleinen Haustieren gefundenen MRSA aber \u00fcberwiegend identisch zu klonalen Linien, die auch in huma\u00adnen Gesundheitseinrichtungen gefunden werden. Insgesamt wird zunehmend deutlich, dass der zoonotische Austausch von MRSA zwischen Mensch und Tier einen wichtigen Einfluss auf die Epidemiologie von MRSA in Deutschland aus\u00fcbt.<\/p>

Schl\u00fcsselw\u00f6rter:<\/strong> S. aureus, MRSA, Zoonose, MedVet-Staph<\/p>","primaryLanguage":"englisch","summary":"Methicillin-resistant Staphylococcus aureus (MRSA) causes colonization and infection both in animals and humans. In Germany, cases of MRSA colonization among humans, w+hich affect 0.5\u20131.5% of the general population and 1.0\u20132.5% of patients at hospital admission, are still mostly associated with previous healthcare contact and defined epidemic clonal lineages. However, MRSA is also distributed in livestock production in Germany, mostly without causing infections in the animals. These MRSA predominantly belong to the clonal complex (CC) 398, but also to CC9 and CC97. Zoonotic transmission of MRSA CC398 from livestock to humans occurs predominantly in people with occupational livestock contact. Spread of MRSA CC398 to household members of these persons is also frequently observed, but dissemination in the general population is limited so far. However, especially in areas with intensive livestock husbandry, about 20\u201338% of MRSA CC398 cases among humans cannot be epidemiologically linked to direct livestock contact, indicating other transmission pathways. MRSA CC398 currently causes about 2% of all human MRSA infections (wound infections, pneumonia, sepsis) in Germany, but up to 10% in regions characterized by a high density of livestock-farming. The burden of MRSA in companion animals was demonstrated to range between 3.6\u20139.4% within wound samples obtained from dogs, cats and horses, respectively. In contrast to livestock and horses, MRSA distributed in pet animals are mostly associated with MRSA clonal lineages that are also prevalent in human healthcare facilities. Overall, zoonotic exchange of MRSA between humans and animals has relevant impact on the epidemiology of MRSA in
Germany.<\/p>

","keywords":["S. aureus","MRSA","zoonosis","MedVet-Staph"],"zusammenfassung":"Methicillin-resistente Staphylococcus aureus (MRSA) verursachen Besiedlungen und Infektionen bei Menschen und Tieren. In Deutschland ist die Mehrzahl der MRSA-F\u00e4lle beim Menschen, die 0,5\u20131,5 % der Allgemeinbev\u00f6lkerung und 1,0\u20132,5 % der Patienten bei Krankenhausaufnahme betreffen, mit vorhergehendem Kontakt zu Einrichtungen des Gesundheitswesens assoziiert. Meist handelt es sich um Besiedlungen durch definierte, epidemisch auftretende MRSA-Genotypen. Zugleich wird MRSA jedoch verbreitet in der landwirtschaftlichen Nutztierhaltung gefunden, meist ohne Infektionen bei den Tieren auszul\u00f6sen. Unter diesen Nutztier-assoziieren MRSA \u00fcberwiegt der klonale Komplex (CC) 398 neben CC9 und CC97. Zoonotische \u00dcbertragungen von MRSA CC398 f\u00fchren zur nasalen Besiedlung von Berufsgruppen mit Nutztierkontakt und deren Haushaltsmitgliedern. Die Verbreitung von MRSA CC398 in der Allgemeinbev\u00f6lkerung ohne Tierkontakt ist bisher eingeschr\u00e4nkt; jedoch k\u00f6nnen, insbesondere in l\u00e4ndlichen Regionen, ca. 20\u201338 % der F\u00e4lle von MRSA CC398 bei Menschen nicht auf einen (in-)direkten Tierkontakt zur\u00fcckgef\u00fchrt werden, was auf andere Transmissionswege hindeutet. MRSA CC398 verursacht derzeit etwa 2 % aller humanen MRSA- Infektionen (Wundinfektion, Pneumonie, Sepsis) in Deutschland, jedoch bis zu 10 % in Regionen mit hoher Tierhaltungsdichte. Bei Hunden, Katzen und Pfer\u00adden werden zwischen 3,6 und 9,4 % der Wundinfektionen durch MRSA ausgel\u00f6st. Anders als bei Nutztieren und Pferden sind die bei kleinen Haustieren gefundenen MRSA aber \u00fcberwiegend identisch zu klonalen Linien, die auch in huma\u00adnen Gesundheitseinrichtungen gefunden werden. Insgesamt wird zunehmend deutlich, dass der zoonotische Austausch von MRSA zwischen Mensch und Tier einen wichtigen Einfluss auf die Epidemiologie von MRSA in Deutschland aus\u00fcbt.<\/p>

","schluesselwoerter":["S. aureus","MRSA","Zoonose","MedVet-Staph"],"translatedTitle":"MRSA als Erreger von Zoonosen in Deutschland","abstractE":"Methicillin-resistant Staphylococcus aureus (MRSA) causes colonization and infection both in animals and humans. In Germany, cases of MRSA colonization among humans, w+hich affect 0.5\u20131.5% of the general population and 1.0\u20132.5% of patients at hospital admission, are still mostly associated with previous healthcare contact and defined epidemic clonal lineages. However, MRSA is also distributed in livestock production in Germany, mostly without causing infections in the animals. These MRSA predominantly belong to the clonal complex (CC) 398, but also to CC9 and CC97. Zoonotic transmission of MRSA CC398 from livestock to humans occurs predominantly in people with occupational livestock contact. Spread of MRSA CC398 to household members of these persons is also frequently observed, but dissemination in the general population is limited so far. However, especially in areas with intensive livestock husbandry, about 20\u201338% of MRSA CC398 cases among humans cannot be epidemiologically linked to direct livestock contact, indicating other transmission pathways. MRSA CC398 currently causes about 2% of all human MRSA infections (wound infections, pneumonia, sepsis) in Germany, but up to 10% in regions characterized by a high density of livestock-farming. The burden of MRSA in companion animals was demonstrated to range between 3.6\u20139.4% within wound samples obtained from dogs, cats and horses, respectively. In contrast to livestock and horses, MRSA distributed in pet animals are mostly associated with MRSA clonal lineages that are also prevalent in human healthcare facilities. Overall, zoonotic exchange of MRSA between humans and animals has relevant impact on the epidemiology of MRSA in Germany.","date":{"year":2014,"date":"09\/2014","accepted":"2014-09-17"},"volume":"127","openAccess":true,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"384-398","redirects":["the-impact-of-zoonotic-mrsa-colonization-and-infection-in-germany\/150\/3130\/81235","the-impact-of-zoonotic-mrsa-colonization-and-infection-in-germany\/150\/3216\/81235"],"tierartCategories":[],"artikelartCategories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"]} CY - Hannover DA - 09/2014 DO - 10.2376/0005-9366-127-384 LA - English N2 - Methicillin-resistant Staphylococcus aureus (MRSA) causes colonization and infection both in animals and humans. In Germany, cases of MRSA colonization among humans, w+hich affect 0.5–1.5% of the general population and 1.0–2.5% of patients at hospital admission, are still mostly associated with previous healthcare contact and defined epidemic clonal lineages. However, MRSA is also distributed in livestock production in Germany, mostly without causing infections in the animals. These MRSA predominantly belong to the clonal complex (CC) 398, but also to CC9 and CC97. Zoonotic transmission of MRSA CC398 from livestock to humans occurs predominantly in people with occupational livestock contact. Spread of MRSA CC398 to household members of these persons is also frequently observed, but dissemination in the general population is limited so far. However, especially in areas with intensive livestock husbandry, about 20–38% of MRSA CC398 cases among humans cannot be epidemiologically linked to direct livestock contact, indicating other transmission pathways. MRSA CC398 currently causes about 2% of all human MRSA infections (wound infections, pneumonia, sepsis) in Germany, but up to 10% in regions characterized by a high density of livestock-farming. The burden of MRSA in companion animals was demonstrated to range between 3.6–9.4% within wound samples obtained from dogs, cats and horses, respectively. In contrast to livestock and horses, MRSA distributed in pet animals are mostly associated with MRSA clonal lineages that are also prevalent in human healthcare facilities. Overall, zoonotic exchange of MRSA between humans and animals has relevant impact on the epidemiology of MRSA in Germany. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2014 SP - 384 EP - 398 T1 - The impact of zoonotic MRSA colonization and infection in Germany T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - The impact of zoonotic MRSA colonization and infection in Germany TT - MRSA als Erreger von Zoonosen in Deutschland VL - 127 SN - 0005-9366 ER -