TY - JOUR KW - Thoroughbred KW - XY testicular DSD KW - horse racing sport AU - C Dierks AU - H Sieme AU - M Piechotta AU - S Lehner AU - J Merkt AU - H Uphaus AU - E Klug AU - O Distl AB - A female thoroughbred successful in horse racing was positively tested for high testosterone values. This horse neither showed stallion-like-behaviour nor signs of ambiguous external genitalia. The karyotype of this horse was 2n=64,XY and the sex-determining region of Y (SRY) PCR was positive. Hair samples tested for naturally testosterone revealed values normal for stallions, and tests for eight synthetic testosterone esters remained negative. The phenotype, ultrasonographic examination, hormone status, cytogenetic evaluation and molecular diagnostics lead to the diagnosis of an XY testicular disorder of sexual development (DSD) due to a complete androgen insensitivity syndrome. To our knowledge this is the first report about a thoroughbred in racing sports with an XY testicular disorder of sexual development. To date, intersex racing horses have never been described in thoroughbreds or a regulation for intersexes in regard to horse races has been issued. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":88701,"title":"Elevated testosterone levels in a racing horse due to an XY testicular disorder of sexual development","topline":"","teaserText":"Erh\u00f6hte Testosteronlevel bei einem Rennpferd als Folge einer XY testikul\u00e4ren St\u00f6rung der Geschlechtsdifferenzierung","content":"

Summary<\/span>
A female thoroughbred successful in horse racing was positively tested for high testosterone values. This horse neither showed stallion-like-behaviour nor signs of ambiguous external genitalia. The karyotype of this horse was 2n=64,XY and the sex-determining region of Y (SRY) PCR was positive. Hair samples tested for naturally testosterone revealed values normal for stallions, and tests for eight synthetic testosterone esters remained negative. The phenotype, ultrasonographic examination, hormone status, cytogenetic evaluation and molecular diagnostics lead to the diagnosis of an XY testicular disorder of sexual development (DSD) due to a complete androgen insensitivity syndrome. To our knowledge this is the first report about a thoroughbred in racing sports with an XY testicular disorder of sexual development. To date, intersex racing horses have never been described in thoroughbreds or a regulation for intersexes in regard to horse races has been issued. <\/p>

Keywords<\/span>
Thoroughbred, XY testicular DSD, horse racing sport<\/p>

Zusammenfassung<\/span>
Bei einer in Galopprennen erfolgreichen Vollblutstute wurden im Rahmen einer Dopingkontrolle erh\u00f6hte Testosteronwerte nachgewiesen. Die Stute zeigte weder hengstartiges Verhalten noch Auff\u00e4lligkeiten der externen Genitalien. Die zyto- und molekulargenetische Untersuchung ergab einen m\u00e4nnlichen Karyotyp von 2n=64,XY bei positiver SRY-PCR (sex-determining region of Y polymerase chain reaction). Die Haaranalyse ergab eine den Hengsten vergleichbare Testosteronkonzentration. Ein Test auf acht synthetische Testosteronester hingegen verlief negativ. Die vorliegenden Befunde der klinischen, ultrasonografischen, hormonellen, zytogenetischen und molekulargenetischen Untersuchungen sprechen f\u00fcr eine XY-testikul\u00e4re Entwicklungsst\u00f6rung der Geschlechtsorgane bei der Stute. Diese Entwicklungsst\u00f6rung beruht auf einer vollst\u00e4ndigen Androgenresistenz. Dies ist der erste Bericht \u00fcber eine XY-testikul\u00e4re Entwicklungsst\u00f6rung der Geschlechtsorgane bei einem Vollblutrennpferd. Bis heute wurden weder intersexuelle Vollblutrennpferde beschrieben noch ist die Teilnahme von intersexuellen Pferden im Rennsport geregelt.<\/p>

Schl\u00fcsselw\u00f6rter<\/span>
Vollblut, XY-testikul\u00e4re DSD, Pferderennsport<\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Jul 7, 2015 10:00:00 PM","oldUrls":["http:\/\/vetline.de\/elevated-testosterone-levels-in-a-racing-horse-due-to-an-xy-testicular-disorder-of-sexual-development\/150\/3130\/88701"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","doiDocumentUri":"http:\/\/www.vetline.de\/elevated-testosterone-levels-in-a-racing-horse-due-to-an-xy-testicular-disorder-of-sexual-development\/150\/3130\/88701\/","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr 128, 335\u2013339 (2015) ","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-128-335","doiFirstPage":"335","doiLastPage":"339","doiTransmitted":true,"doiAuthor":"Dierks C, Sieme H, Piechotta M, Lehner S, Merkt J, Uphaus H, Klug E, Distl O","pdf":{"path":"http:\/\/data\/BMW_2015_07_08_0335.pdf","title":"BMW_2015_07_08_0335.pdf","description":"Elevated testosterone levels in a racing horse due to an XY testicular disorder of sexual development"},"authors":[{"firstName":"C","middleName":"","lastName":"Dierks"},{"firstName":"H","middleName":"","lastName":"Sieme"},{"firstName":"M","middleName":"","lastName":"Piechotta"},{"firstName":"S","middleName":"","lastName":"Lehner"},{"firstName":"J","middleName":"","lastName":"Merkt"},{"firstName":"H","middleName":"","lastName":"Uphaus"},{"firstName":"E","middleName":"","lastName":"Klug"},{"firstName":"O","middleName":"","lastName":"Distl"}],"contentOptimised":"

Summary<\/strong>
A female thoroughbred successful in horse racing was positively tested for high testosterone values. This horse neither showed stallion-like-behaviour nor signs of ambiguous external genitalia. The karyotype of this horse was 2n=64,XY and the sex-determining region of Y (SRY) PCR was positive. Hair samples tested for naturally testosterone revealed values normal for stallions, and tests for eight synthetic testosterone esters remained negative. The phenotype, ultrasonographic examination, hormone status, cytogenetic evaluation and molecular diagnostics lead to the diagnosis of an XY testicular disorder of sexual development (DSD) due to a complete androgen insensitivity syndrome. To our knowledge this is the first report about a thoroughbred in racing sports with an XY testicular disorder of sexual development. To date, intersex racing horses have never been described in thoroughbreds or a regulation for intersexes in regard to horse races has been issued. <\/p>

Keywords:<\/strong>
Thoroughbred, XY testicular DSD, horse racing sport<\/p>

Zusammenfassung<\/strong>
Bei einer in Galopprennen erfolgreichen Vollblutstute wurden im Rahmen einer Dopingkontrolle erh\u00f6hte Testosteronwerte nachgewiesen. Die Stute zeigte weder hengstartiges Verhalten noch Auff\u00e4lligkeiten der externen Genitalien. Die zyto- und molekulargenetische Untersuchung ergab einen m\u00e4nnlichen Karyotyp von 2n=64,XY bei positiver SRY-PCR (sex-determining region of Y polymerase chain reaction). Die Haaranalyse ergab eine den Hengsten vergleichbare Testosteronkonzentration. Ein Test auf acht synthetische Testosteronester hingegen verlief negativ. Die vorliegenden Befunde der klinischen, ultrasonografischen, hormonellen, zytogenetischen und molekulargenetischen Untersuchungen sprechen f\u00fcr eine XY-testikul\u00e4re Entwicklungsst\u00f6rung der Geschlechtsorgane bei der Stute. Diese Entwicklungsst\u00f6rung beruht auf einer vollst\u00e4ndigen Androgenresistenz. Dies ist der erste Bericht \u00fcber eine XY-testikul\u00e4re Entwicklungsst\u00f6rung der Geschlechtsorgane bei einem Vollblutrennpferd. Bis heute wurden weder intersexuelle Vollblutrennpferde beschrieben noch ist die Teilnahme von intersexuellen Pferden im Rennsport geregelt.<\/p>

Schl\u00fcsselw\u00f6rter:<\/strong>
Vollblut, XY-testikul\u00e4re DSD, Pferderennsport<\/p>","primaryLanguage":"englisch","summary":"A female thoroughbred successful in horse racing was positively tested for high testosterone values. This horse neither showed stallion-like-behaviour nor signs of ambiguous external genitalia. The karyotype of this horse was 2n=64,XY and the sex-determining region of Y (SRY) PCR was positive. Hair samples tested for naturally testosterone revealed values normal for stallions, and tests for eight synthetic testosterone esters remained negative. The phenotype, ultrasonographic examination, hormone status, cytogenetic evaluation and molecular diagnostics lead to the diagnosis of an XY testicular disorder of sexual development (DSD) due to a complete androgen insensitivity syndrome. To our knowledge this is the first report about a thoroughbred in racing sports with an XY testicular disorder of sexual development. To date, intersex racing horses have never been described in thoroughbreds or a regulation for intersexes in regard to horse races has been issued. <\/p>

","keywords":["Thoroughbred","XY testicular DSD","horse racing sport"],"zusammenfassung":"Bei einer in Galopprennen erfolgreichen Vollblutstute wurden im Rahmen einer Dopingkontrolle erh\u00f6hte Testosteronwerte nachgewiesen. Die Stute zeigte weder hengstartiges Verhalten noch Auff\u00e4lligkeiten der externen Genitalien. Die zyto- und molekulargenetische Untersuchung ergab einen m\u00e4nnlichen Karyotyp von 2n=64,XY bei positiver SRY-PCR (sex-determining region of Y polymerase chain reaction). Die Haaranalyse ergab eine den Hengsten vergleichbare Testosteronkonzentration. Ein Test auf acht synthetische Testosteronester hingegen verlief negativ. Die vorliegenden Befunde der klinischen, ultrasonografischen, hormonellen, zytogenetischen und molekulargenetischen Untersuchungen sprechen f\u00fcr eine XY-testikul\u00e4re Entwicklungsst\u00f6rung der Geschlechtsorgane bei der Stute. Diese Entwicklungsst\u00f6rung beruht auf einer vollst\u00e4ndigen Androgenresistenz. Dies ist der erste Bericht \u00fcber eine XY-testikul\u00e4re Entwicklungsst\u00f6rung der Geschlechtsorgane bei einem Vollblutrennpferd. Bis heute wurden weder intersexuelle Vollblutrennpferde beschrieben noch ist die Teilnahme von intersexuellen Pferden im Rennsport geregelt.<\/p>

","schluesselwoerter":["Vollblut","XY-testikul\u00e4re DSD","Pferderennsport"],"translatedTitle":"Erh\u00f6hte Testosteronlevel bei einem Rennpferd als Folge einer XY testikul\u00e4ren St\u00f6rung der Geschlechtsdifferenzierung","abstractE":"A female thoroughbred successful in horse racing was positively tested for high testosterone values. This horse neither showed stallion-like-behaviour nor signs of ambiguous external genitalia. The karyotype of this horse was 2n=64,XY and the sex-determining region of Y (SRY) PCR was positive. Hair samples tested for naturally testosterone revealed values normal for stallions, and tests for eight synthetic testosterone esters remained negative. The phenotype, ultrasonographic examination, hormone status, cytogenetic evaluation and molecular diagnostics lead to the diagnosis of an XY testicular disorder of sexual development (DSD) due to a complete androgen insensitivity syndrome. To our knowledge this is the first report about a thoroughbred in racing sports with an XY testicular disorder of sexual development. To date, intersex racing horses have never been described in thoroughbreds or a regulation for intersexes in regard to horse races has been issued. ","date":{"year":2015,"date":"07\/2015","accepted":"2015-07-07"},"volume":"128","openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"335-339","redirects":["elevated-testosterone-levels-in-a-racing-horse-due-to-an-xy-testicular-disorder-of-sexual-development\/150\/3130\/88701"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} CY - Hannover DA - 07/2015 DO - 10.2376/0005-9366-128-335 ET - 7/8 LA - English N2 - A female thoroughbred successful in horse racing was positively tested for high testosterone values. This horse neither showed stallion-like-behaviour nor signs of ambiguous external genitalia. The karyotype of this horse was 2n=64,XY and the sex-determining region of Y (SRY) PCR was positive. Hair samples tested for naturally testosterone revealed values normal for stallions, and tests for eight synthetic testosterone esters remained negative. The phenotype, ultrasonographic examination, hormone status, cytogenetic evaluation and molecular diagnostics lead to the diagnosis of an XY testicular disorder of sexual development (DSD) due to a complete androgen insensitivity syndrome. To our knowledge this is the first report about a thoroughbred in racing sports with an XY testicular disorder of sexual development. To date, intersex racing horses have never been described in thoroughbreds or a regulation for intersexes in regard to horse races has been issued. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2015 SP - 335 EP - 339 T1 - Elevated testosterone levels in a racing horse due to an XY testicular disorder of sexual development T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Elevated testosterone levels in a racing horse due to an XY testicular disorder of sexual development TT - Erhöhte Testosteronlevel bei einem Rennpferd als Folge einer XY testikulären Störung der Geschlechtsdifferenzierung VL - 128 SN - 0005-9366 ER -