TY - JOUR KW - Borrelia KW - cat KW - EIA AU - N Pantchev AU - M Globokar Vrhovec AU - S Pluta AU - R Straubinger AB - There are only few reports on Lyme borreliosis (LB) in cats. The reasons might be a different tick infestation in cats compared to dogs, a low susceptibility for tick-borne infections or a low awareness of veterinarians for tick-borne diseases in feline patients. The aim of this study was to determine the proportion of antibodies against Borrelia burgdorferi sensu lato (Bbsl) in feline sera, to compare the significance of feline versus canine LB, as well as to evaluate possible implications on disease occurrence. Specific antibodies against the C6-peptide of Bbsl in cats were detected by a rapid test based on enzyme immunoassay technique. The serum samples were sent to a diagnostic laboratory by veterinarians from Germany and other European countries with request for Borrelia serology in the years 2009–2011. Veterinarians were asked for information regarding the cats’ location, age, gender, clinical signs, treatment and follow-up. In six of 271 (2.2%; 95% CI: 0.8–4.8%) cat sera, antibodies against the C6-peptide of Bbsl were detected. Proportion of Borrelia antibody-positive cat sera was significantly lower than the one determined for dogs during the same time period. All positive cats lived in countries endemic for LB (Germany, Sweden and Belgium), and all C6-antibody positive cats with the exception of one cat showed clinical signs. Possible implications on disease occurrence are discussed. Data presented here demonstrate a lower prevalence of Borrelia specific C6-antibodies in European cats when compared to dogs residing in the same regions. The absence of antibodies against Bbsl in 97.8% (95% CI: 95.2–99.2%) of the submitted samples indicate that diagnosis “feline LB” is rare in cats. Nevertheless, LB should be considered in cats with compatible clinical signs (e.g. shifting leg lameness, to less extent neurological signs) when other differential diagnoses are ruled out. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":96491,"title":"Seropositivity of Borrelia burgdorferi in a cohort of symptomatic cats from Europe based on a C6-peptide assay with discussion of implications in disease aetiology","topline":"","teaserText":"Seropositivit\u00e4t von Borrelia burgdorferi in einer Kohorte von symptomatischen Katzen aus Europa auf der Grundlage eines C6-Peptid-Tests mit Diskussion der Auswirkungen auf den Erkrankungsverlauf","content":"

Summary<\/span>
There are only few reports on Lyme borreliosis (LB) in cats. The reasons might be a different tick infestation in cats compared to dogs, a low susceptibility for tick-borne infections or a low awareness of veterinarians for tick-borne diseases in feline patients. The aim of this study was to determine the proportion of antibodies against Borrelia burgdorferi sensu lato (Bbsl) in feline sera, to compare the significance of feline versus canine LB, as well as to evaluate possible implications on disease occurrence. Specific antibodies against the C6-peptide of Bbsl in cats were detected by a rapid test based on enzyme immunoassay technique. The serum samples were sent to a diagnostic laboratory by veterinarians from Germany and other European countries with request for Borrelia serology in the years 2009\u20132011. Veterinarians were asked for information regarding the cats\u2019 location, age, gender, clinical signs, treatment and follow-up. In six of 271 (2.2%; 95% CI: 0.8\u20134.8%) cat sera, antibodies against the C6-peptide of Bbsl were detected. Proportion of Borrelia antibody-positive cat sera was significantly lower than the one determined for dogs during the same time period. All positive cats lived in countries endemic for LB (Germany, Sweden and Belgium), and all C6-antibody positive cats with the exception of one cat showed clinical signs. Possible implications on disease occurrence are discussed. Data presented here demonstrate a lower prevalence of Borrelia specific C6-antibodies in European cats when compared to dogs residing in the same regions. The absence of antibodies against Bbsl in 97.8% (95% CI: 95.2\u201399.2%) of the submitted samples indicate that diagnosis \u201cfeline LB\u201d is rare in cats. Nevertheless, LB should be considered in cats with compatible clinical signs (e.g. shifting leg lameness, to less extent neurological signs) when other differential diagnoses are ruled out.<\/p>

Keywords<\/span>
Borrelia, cat, EIA<\/p>

Zusammenfassung<\/span>
Es existieren nur wenige Berichte \u00fcber Lyme-Borreliose (LB) bei Katzen. Die Gr\u00fcnde daf\u00fcr k\u00f6nnten in der im Vergleich zum Hund unterschiedlichen Zeckeninfestation der Katzen, geringeren Empf\u00e4nglichkeit f\u00fcr Zecken-\u00fcbertragene Infektionen oder einer geringen Wahrnehmung der durch Zecken-\u00fcbertragenen Erkrankungen bei Katzen seitens der Tier\u00e4rzte liegen. Das Ziel dieser Studie war Borrelia burgdorferi sensu lato(Bbsl)-seropositive Katzen auszuwerten und sie mit den Daten von seropositiven Hunden zu vergleichen. Des Weiteren wurde eine m\u00f6gliche Auswirkung auf den Erkrankungsverlauf diskutiert. Spezifische Antik\u00f6rper gegen das Bbsl-C6-Peptid bei Katzen wurden mittels eines Schnelltests (basierend auf Enzymimmunoassay-Technologie) nachgewiesen. Die Serumproben wurden zwischen 2009 und 2011 von Tierarztpraxen aus Deutschland und anderen europ\u00e4ischen L\u00e4ndern f\u00fcr die Untersuchung auf Borrelia-Antik\u00f6rper an ein diagnostisches Labor eingeschickt. Tier\u00e4rzte haben zus\u00e4tzlich Fragen \u00fcber Herkunft, Alter, Geschlecht, klinische Ver\u00e4nderungen, Therapie und den weiteren Verlauf beantwortet. In sechs von 271 (2,2 %; 95%-CI: 0,8\u20134,8 %) Katzensera wurden Antik\u00f6rper gegen das Bbsl-C6-Peptid festgestellt. Der Anteil von Borreliaseropositiven Katzen, untersucht mit dem C6-basierten Test, war signifikant niedriger als der Anteil von seropositiven Hunden, die im gleichen Zeitraum untersucht wurden. Alle seropositiven Katzen lebten in L\u00e4ndern en demisch f\u00fcr LB (Deutschland, Schweden und Belgien) und zeigten mit Ausnahme von einer Katze klinische Symptome. Die hier dargestellten Daten zeigen eine niedrigere Seropr\u00e4valenz f\u00fcr Borrelia-C6-Antik\u00f6rper bei europ\u00e4ischen Katzen im Vergleich zu den in den gleichen Regionen lebenden Hunden. Das Fehlen von BbslAntik\u00f6rpern in 97,8 % (95%-CI: 95,2\u201399,2 %) der eingeschickten Proben deutet darauf hin, dass die Diagnose \u201efeline LB\u201c selten zu erwarten ist. Nichtsdestotrotz sollte die Erkrankung bei klinisch apparenten Katzen (wechselnde Lahmheit, weniger auch mit neurologischen Symptomen) nach dem Ausschluss von anderen Differenzialdiagnosen ber\u00fccksichtigt werden.<\/p>

Schl\u00fcsselw\u00f6rter<\/span>
Borrelia, Katze, EIA<\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Jul 10, 2016 10:00:00 PM","oldUrls":["http:\/\/vetline.de\/seropositivity-of-borrelia-burgdorferi-in-a-cohort-of-symptomatic-cats-from-europe-based-on-a-c6-peptide-assay-with-discussion-of-implications-in-disease-aetiology\/150\/3130\/96491"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift ","doiDocumentUri":"http:\/\/www.vetline.de\/seropositivity-of-borrelia-burgdorferi-in-a-cohort-of-symptomatic-cats-from-europe-based-on-a-c6-peptide-assay-with-discussion-of-implications-in-disease-aetiology\/150\/3130\/96491\/","doiSource":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift 129, Heft 7\/8 (2016), Seiten 333\u2013339","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-15088","doiFirstPage":"333","doiLastPage":"339","doiTransmitted":true,"doiAuthor":"Pantchev N, Globokar Vrhovec M, Pluta S, Straubinger R","pdf":{"path":"http:\/\/data\/BMW_2016_07_08_0333.pdf","title":"BMW_2016_07_08_0333.pdf","description":"Seropositivity of Borrelia burgdorferi in a cohort of symptomatic cats from Europe based on a C6-peptide assay with discussion of implications in disease aetiology "},"authors":[{"firstName":"N","middleName":"","lastName":"Pantchev"},{"firstName":"M","middleName":"","lastName":"Globokar Vrhovec"},{"firstName":"S","middleName":"","lastName":"Pluta"},{"firstName":"R","middleName":"","lastName":"Straubinger"}],"contentOptimised":"

Summary<\/strong>
There are only few reports on Lyme borreliosis (LB) in cats. The reasons might be a different tick infestation in cats compared to dogs, a low susceptibility for tick-borne infections or a low awareness of veterinarians for tick-borne diseases in feline patients. The aim of this study was to determine the proportion of antibodies against Borrelia burgdorferi sensu lato (Bbsl) in feline sera, to compare the significance of feline versus canine LB, as well as to evaluate possible implications on disease occurrence. Specific antibodies against the C6-peptide of Bbsl in cats were detected by a rapid test based on enzyme immunoassay technique. The serum samples were sent to a diagnostic laboratory by veterinarians from Germany and other European countries with request for Borrelia serology in the years 2009\u20132011. Veterinarians were asked for information regarding the cats\u2019 location, age, gender, clinical signs, treatment and follow-up. In six of 271 (2.2%; 95% CI: 0.8\u20134.8%) cat sera, antibodies against the C6-peptide of Bbsl were detected. Proportion of Borrelia antibody-positive cat sera was significantly lower than the one determined for dogs during the same time period. All positive cats lived in countries endemic for LB (Germany, Sweden and Belgium), and all C6-antibody positive cats with the exception of one cat showed clinical signs. Possible implications on disease occurrence are discussed. Data presented here demonstrate a lower prevalence of Borrelia specific C6-antibodies in European cats when compared to dogs residing in the same regions. The absence of antibodies against Bbsl in 97.8% (95% CI: 95.2\u201399.2%) of the submitted samples indicate that diagnosis \u201cfeline LB\u201d is rare in cats. Nevertheless, LB should be considered in cats with compatible clinical signs (e.g. shifting leg lameness, to less extent neurological signs) when other differential diagnoses are ruled out.<\/p>

Keywords:<\/strong>
Borrelia, cat, EIA<\/p>

Zusammenfassung<\/strong>
Es existieren nur wenige Berichte \u00fcber Lyme-Borreliose (LB) bei Katzen. Die Gr\u00fcnde daf\u00fcr k\u00f6nnten in der im Vergleich zum Hund unterschiedlichen Zeckeninfestation der Katzen, geringeren Empf\u00e4nglichkeit f\u00fcr Zecken-\u00fcbertragene Infektionen oder einer geringen Wahrnehmung der durch Zecken-\u00fcbertragenen Erkrankungen bei Katzen seitens der Tier\u00e4rzte liegen. Das Ziel dieser Studie war Borrelia burgdorferi sensu lato(Bbsl)-seropositive Katzen auszuwerten und sie mit den Daten von seropositiven Hunden zu vergleichen. Des Weiteren wurde eine m\u00f6gliche Auswirkung auf den Erkrankungsverlauf diskutiert. Spezifische Antik\u00f6rper gegen das Bbsl-C6-Peptid bei Katzen wurden mittels eines Schnelltests (basierend auf Enzymimmunoassay-Technologie) nachgewiesen. Die Serumproben wurden zwischen 2009 und 2011 von Tierarztpraxen aus Deutschland und anderen europ\u00e4ischen L\u00e4ndern f\u00fcr die Untersuchung auf Borrelia-Antik\u00f6rper an ein diagnostisches Labor eingeschickt. Tier\u00e4rzte haben zus\u00e4tzlich Fragen \u00fcber Herkunft, Alter, Geschlecht, klinische Ver\u00e4nderungen, Therapie und den weiteren Verlauf beantwortet. In sechs von 271 (2,2 %; 95%-CI: 0,8\u20134,8 %) Katzensera wurden Antik\u00f6rper gegen das Bbsl-C6-Peptid festgestellt. Der Anteil von Borreliaseropositiven Katzen, untersucht mit dem C6-basierten Test, war signifikant niedriger als der Anteil von seropositiven Hunden, die im gleichen Zeitraum untersucht wurden. Alle seropositiven Katzen lebten in L\u00e4ndern en demisch f\u00fcr LB (Deutschland, Schweden und Belgien) und zeigten mit Ausnahme von einer Katze klinische Symptome. Die hier dargestellten Daten zeigen eine niedrigere Seropr\u00e4valenz f\u00fcr Borrelia-C6-Antik\u00f6rper bei europ\u00e4ischen Katzen im Vergleich zu den in den gleichen Regionen lebenden Hunden. Das Fehlen von BbslAntik\u00f6rpern in 97,8 % (95%-CI: 95,2\u201399,2 %) der eingeschickten Proben deutet darauf hin, dass die Diagnose \u201efeline LB\u201c selten zu erwarten ist. Nichtsdestotrotz sollte die Erkrankung bei klinisch apparenten Katzen (wechselnde Lahmheit, weniger auch mit neurologischen Symptomen) nach dem Ausschluss von anderen Differenzialdiagnosen ber\u00fccksichtigt werden.<\/p>

Schl\u00fcsselw\u00f6rter:<\/strong>
Borrelia, Katze, EIA<\/p>","primaryLanguage":"englisch","summary":"There are only few reports on Lyme borreliosis (LB) in cats. The reasons might be a different tick infestation in cats compared to dogs, a low susceptibility for tick-borne infections or a low awareness of veterinarians for tick-borne diseases in feline patients. The aim of this study was to determine the proportion of antibodies against Borrelia burgdorferi sensu lato (Bbsl) in feline sera, to compare the significance of feline versus canine LB, as well as to evaluate possible implications on disease occurrence. Specific antibodies against the C6-peptide of Bbsl in cats were detected by a rapid test based on enzyme immunoassay technique. The serum samples were sent to a diagnostic laboratory by veterinarians from Germany and other European countries with request for Borrelia serology in the years 2009\u20132011. Veterinarians were asked for information regarding the cats\u2019 location, age, gender, clinical signs, treatment and follow-up. In six of 271 (2.2%; 95% CI: 0.8\u20134.8%) cat sera, antibodies against the C6-peptide of Bbsl were detected. Proportion of Borrelia antibody-positive cat sera was significantly lower than the one determined for dogs during the same time period. All positive cats lived in countries endemic for LB (Germany, Sweden and Belgium), and all C6-antibody positive cats with the exception of one cat showed clinical signs. Possible implications on disease occurrence are discussed. Data presented here demonstrate a lower prevalence of Borrelia specific C6-antibodies in European cats when compared to dogs residing in the same regions. The absence of antibodies against Bbsl in 97.8% (95% CI: 95.2\u201399.2%) of the submitted samples indicate that diagnosis \u201cfeline LB\u201d is rare in cats. Nevertheless, LB should be considered in cats with compatible clinical signs (e.g. shifting leg lameness, to less extent neurological signs) when other differential diagnoses are ruled out.<\/p>

","keywords":["Borrelia","cat","EIA"],"zusammenfassung":"Es existieren nur wenige Berichte \u00fcber Lyme-Borreliose (LB) bei Katzen. Die Gr\u00fcnde daf\u00fcr k\u00f6nnten in der im Vergleich zum Hund unterschiedlichen Zeckeninfestation der Katzen, geringeren Empf\u00e4nglichkeit f\u00fcr Zecken-\u00fcbertragene Infektionen oder einer geringen Wahrnehmung der durch Zecken-\u00fcbertragenen Erkrankungen bei Katzen seitens der Tier\u00e4rzte liegen. Das Ziel dieser Studie war Borrelia burgdorferi sensu lato(Bbsl)-seropositive Katzen auszuwerten und sie mit den Daten von seropositiven Hunden zu vergleichen. Des Weiteren wurde eine m\u00f6gliche Auswirkung auf den Erkrankungsverlauf diskutiert. Spezifische Antik\u00f6rper gegen das Bbsl-C6-Peptid bei Katzen wurden mittels eines Schnelltests (basierend auf Enzymimmunoassay-Technologie) nachgewiesen. Die Serumproben wurden zwischen 2009 und 2011 von Tierarztpraxen aus Deutschland und anderen europ\u00e4ischen L\u00e4ndern f\u00fcr die Untersuchung auf Borrelia-Antik\u00f6rper an ein diagnostisches Labor eingeschickt. Tier\u00e4rzte haben zus\u00e4tzlich Fragen \u00fcber Herkunft, Alter, Geschlecht, klinische Ver\u00e4nderungen, Therapie und den weiteren Verlauf beantwortet. In sechs von 271 (2,2 %; 95%-CI: 0,8\u20134,8 %) Katzensera wurden Antik\u00f6rper gegen das Bbsl-C6-Peptid festgestellt. Der Anteil von Borreliaseropositiven Katzen, untersucht mit dem C6-basierten Test, war signifikant niedriger als der Anteil von seropositiven Hunden, die im gleichen Zeitraum untersucht wurden. Alle seropositiven Katzen lebten in L\u00e4ndern en demisch f\u00fcr LB (Deutschland, Schweden und Belgien) und zeigten mit Ausnahme von einer Katze klinische Symptome. Die hier dargestellten Daten zeigen eine niedrigere Seropr\u00e4valenz f\u00fcr Borrelia-C6-Antik\u00f6rper bei europ\u00e4ischen Katzen im Vergleich zu den in den gleichen Regionen lebenden Hunden. Das Fehlen von BbslAntik\u00f6rpern in 97,8 % (95%-CI: 95,2\u201399,2 %) der eingeschickten Proben deutet darauf hin, dass die Diagnose \u201efeline LB\u201c selten zu erwarten ist. Nichtsdestotrotz sollte die Erkrankung bei klinisch apparenten Katzen (wechselnde Lahmheit, weniger auch mit neurologischen Symptomen) nach dem Ausschluss von anderen Differenzialdiagnosen ber\u00fccksichtigt werden.<\/p>

","schluesselwoerter":["Borrelia","Katze","EIA"],"translatedTitle":"Seropositivit\u00e4t von Borrelia burgdorferi in einer Kohorte von symptomatischen Katzen aus Europa auf der Grundlage eines C6-Peptid-Tests mit Diskussion der Auswirkungen auf den Erkrankungsverlauf","abstractE":"There are only few reports on Lyme borreliosis (LB) in cats. The reasons might be a different tick infestation in cats compared to dogs, a low susceptibility for tick-borne infections or a low awareness of veterinarians for tick-borne diseases in feline patients. The aim of this study was to determine the proportion of antibodies against Borrelia burgdorferi sensu lato (Bbsl) in feline sera, to compare the significance of feline versus canine LB, as well as to evaluate possible implications on disease occurrence. Specific antibodies against the C6-peptide of Bbsl in cats were detected by a rapid test based on enzyme immunoassay technique. The serum samples were sent to a diagnostic laboratory by veterinarians from Germany and other European countries with request for Borrelia serology in the years 2009\u20132011. Veterinarians were asked for information regarding the cats\u2019 location, age, gender, clinical signs, treatment and follow-up. In six of 271 (2.2%; 95% CI: 0.8\u20134.8%) cat sera, antibodies against the C6-peptide of Bbsl were detected. Proportion of Borrelia antibody-positive cat sera was significantly lower than the one determined for dogs during the same time period. All positive cats lived in countries endemic for LB (Germany, Sweden and Belgium), and all C6-antibody positive cats with the exception of one cat showed clinical signs. Possible implications on disease occurrence are discussed. Data presented here demonstrate a lower prevalence of Borrelia specific C6-antibodies in European cats when compared to dogs residing in the same regions. The absence of antibodies against Bbsl in 97.8% (95% CI: 95.2\u201399.2%) of the submitted samples indicate that diagnosis \u201cfeline LB\u201d is rare in cats. Nevertheless, LB should be considered in cats with compatible clinical signs (e.g. shifting leg lameness, to less extent neurological signs) when other differential diagnoses are ruled out.","date":{"year":2016,"date":"07\/2016","accepted":"2016-07-10"},"volume":"129","openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"333-339","redirects":["seropositivity-of-borrelia-burgdorferi-in-a-cohort-of-symptomatic-cats-from-europe-based-on-a-c6-peptide-assay-with-discussion-of-implications-in-disease-aetiology\/150\/3130\/96491"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} CY - Hannover DA - 07/2016 DO - 10.2376/0005-9366-15088 ET - 7/8 LA - English N2 - There are only few reports on Lyme borreliosis (LB) in cats. The reasons might be a different tick infestation in cats compared to dogs, a low susceptibility for tick-borne infections or a low awareness of veterinarians for tick-borne diseases in feline patients. The aim of this study was to determine the proportion of antibodies against Borrelia burgdorferi sensu lato (Bbsl) in feline sera, to compare the significance of feline versus canine LB, as well as to evaluate possible implications on disease occurrence. Specific antibodies against the C6-peptide of Bbsl in cats were detected by a rapid test based on enzyme immunoassay technique. The serum samples were sent to a diagnostic laboratory by veterinarians from Germany and other European countries with request for Borrelia serology in the years 2009–2011. Veterinarians were asked for information regarding the cats’ location, age, gender, clinical signs, treatment and follow-up. In six of 271 (2.2%; 95% CI: 0.8–4.8%) cat sera, antibodies against the C6-peptide of Bbsl were detected. Proportion of Borrelia antibody-positive cat sera was significantly lower than the one determined for dogs during the same time period. All positive cats lived in countries endemic for LB (Germany, Sweden and Belgium), and all C6-antibody positive cats with the exception of one cat showed clinical signs. Possible implications on disease occurrence are discussed. Data presented here demonstrate a lower prevalence of Borrelia specific C6-antibodies in European cats when compared to dogs residing in the same regions. The absence of antibodies against Bbsl in 97.8% (95% CI: 95.2–99.2%) of the submitted samples indicate that diagnosis “feline LB” is rare in cats. Nevertheless, LB should be considered in cats with compatible clinical signs (e.g. shifting leg lameness, to less extent neurological signs) when other differential diagnoses are ruled out. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2016 SP - 333 EP - 339 T1 - Seropositivity of Borrelia burgdorferi in a cohort of symptomatic cats from Europe based on a C6-peptide assay with discussion of implications in disease aetiology T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Seropositivity of Borrelia burgdorferi in a cohort of symptomatic cats from Europe based on a C6-peptide assay with discussion of implications in disease aetiology TT - Seropositivität von Borrelia burgdorferi in einer Kohorte von symptomatischen Katzen aus Europa auf der Grundlage eines C6-Peptid-Tests mit Diskussion der Auswirkungen auf den Erkrankungsverlauf VL - 129 SN - 0005-9366 ER -