TY - JOUR AU - A Engelhardt AU - K-F Stock AU - H Hamann AU - R Brahm AU - H Grußendorf AU - C Rosenhagen AU - O Distl AB - Genetic parameters were estimated for prevalences of primary cataract (CAT), persistent pupillary membrane (PPM) and distichiasis (DIST) in 615 single-colored and 617 multi-colored English Cocker Spaniels (ECS) bred in the German kennel club for Spaniels (Jagdspaniel-Klub e. V.). CAT or CAT diagnosed in dogs up to three and a half years of age (early-onset cataract, CAT-early) and CAT diagnosed in dogs over three and a half years of age (late-onset cataract, CAT-late), PPM and DIST were included as binary traits in multivariate genetic analyses. Heritabilities on the underlying liability scale were 0.15 for CAT, 0.34 for CAT-early, 0.13 for CAT-late, 0.46 for PPM, and 0.62 for DIST in single-colored ECS and 0.06 for CAT, 0.13 for CAT-early, 0.14 for CAT-late, 0.10 for PPM, and 0.61 for DIST in multi-colored ECS.There were indications for a different genetic basis of CAT-early and CAT-late in single-colored ECS as genetic correlations were close to zero. In multi-colored ECS, a similar tendency for CAT-early and CAT-late could be observed. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":70568,"title":"Analysis of systematic and genetic effects on the prevalence of primary cataract, persistent pupillary membrane and distichiasis in the two color variants of English Cocker Spaniels in Germany","teaserText":"DOI 10.2376\/0005-9366-120-490","content":"

Summary<\/span>
Genetic parameters were estimated for prevalences of primary cataract (CAT), persistent pupillary membrane (PPM) and distichiasis (DIST) in 615 single-colored and 617 multi-colored English Cocker Spaniels (ECS) bred in the German kennel club for Spaniels (Jagdspaniel-Klub e. V.). CAT or CAT diagnosed in dogs up to three and a half years of age (early-onset cataract, CAT-early) and CAT diagnosed in dogs over three and a half years of age (late-onset cataract, CAT-late), PPM and DIST were included as binary traits in multivariate genetic analyses. Heritabilities on the underlying liability scale were 0.15 for CAT, 0.34 for CAT-early, 0.13 for CAT-late, 0.46 for PPM, and 0.62 for DIST in single-colored ECS and 0.06 for CAT, 0.13 for CAT-early, 0.14 for CAT-late, 0.10 for PPM, and 0.61 for DIST in multi-colored ECS.There were indications for a different genetic basis of CAT-early and CAT-late in single-colored ECS as genetic correlations were close to zero. In multi-colored ECS, a similar tendency for CAT-early and CAT-late could be observed.


Zusammenfassung<\/span>
Bei 615 einfarbigen und 617 mehrfarbigen Englischen Cocker Spaniels (ECS) wurden die genetischen Parameter f\u00fcr prim\u00e4re Katarakt (CAT), persistierende Pupillarmembran (PPM) und Distichiasis (DIST) gesch\u00e4tzt. Alle ophthalmologisch untersuchten Hunde wurden im Jagdspaniel-Klub e.V. gez\u00fcchtet. Prim\u00e4re Katarakt insgesamt oder prim\u00e4re Katarakt diagnostiziert bei Hunden bis zum Alter von 3,5 Jahren (fr\u00fch-manifeste Katarakt, CAT-early) und prim\u00e4re Katarakt diagnostiziert bei Hunden mit einem Alter von mehr als 3,5 Jahren (sp\u00e4t-manifeste Katarakt, CAT-late), PPM and DIST wurden als bin\u00e4re Merkmale in den multivariaten genetischen Analysen ber\u00fccksichtigt. Die Heritabilit\u00e4ten betrugen nach Transformation in ein Schwellenwertmodell h2 = 0,15 f\u00fcr die prim\u00e4re Katarakt, 0,34 f\u00fcr die fr\u00fch-manifeste prim\u00e4re Katarakt, 0,13 f\u00fcr die sp\u00e4t-manifeste prim\u00e4re Katarakt, 0,46 f\u00fcr PPM und 0,62 f\u00fcr DIST bei den einfarbigen ECS. Bei den mehrfarbigen ECS lagen die Herita-bilit\u00e4tssch\u00e4tzwerte bei h2 = 0,06 f\u00fcr die prim\u00e4re Katarakt, 0,13 f\u00fcr die fr\u00fch-manifeste prim\u00e4re Katarakt, 0,14 f\u00fcr die sp\u00e4t-manifeste prim\u00e4re Katarakt, 0,10 f\u00fcr PPM und 0,61 f\u00fcr DIST. Da die genetischen Korrelationen bei den einfarbigen ECS nahe bei Null lagen, ist davon auszugehen, dass bei dieser Farbvariante der ECS fr\u00fch-manifeste Katarakt und sp\u00e4t-manifeste Katarakt genetisch unterschiedliche Merkmale darstellen. \u00c4hnliches konnte bei mehrfarbigen ECS f\u00fcr diese beiden sich fr\u00fch und sp\u00e4t im Leben manifestierenden Kataraktformen beobachtet werden.<\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Nov 1, 2007 12:00:00 AM","toDate":"Dec 31, 2050 12:00:00 AM","oldUrls":["http:\/\/vetline.de\/21594660\/150\/3130\/70568"],"doiLanguage":"englisch","doiProductFormat":"Online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl. M\u00fcnch. Tier\u00e4rztl. Wschr.","doiDocumentUri":"http:\/\/www.vetline.de\/21594660\/150\/3130\/70568","doiSource":"Berl. M\u00fcnch. Tier\u00e4rztl. Wschr. 120: 11-12, 490-498 (2007)","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-120-490","doiFirstPage":"490","doiLastPage":"498","doiTransmitted":true,"doiAuthor":"Engelhardt A, Stock K F, Hamann H, Brahm R, Gru\u00dfendorf H, Rosenhagen C U, Distl O","pdf":{"path":"http:\/\/data\/bmtw_2007_11_0490.pdf","title":"bmtw_2007_11_0490.pdf","description":"Analysis of systematic and genetic effects on the prevalence of primary cataract, persistent pupillary membrane and distichiasis in the two color variants of English Cocker Spaniels in Germany

"},"authors":[{"firstName":"A","middleName":"","lastName":"Engelhardt"},{"firstName":"K","middleName":"F","lastName":"Stock"},{"firstName":"H","middleName":"","lastName":"Hamann"},{"firstName":"R","middleName":"","lastName":"Brahm"},{"firstName":"H","middleName":"","lastName":"Gru\u00dfendorf"},{"firstName":"C","middleName":"U","lastName":"Rosenhagen"},{"firstName":"O","middleName":"","lastName":"Distl"}],"contentOptimised":"

Summary<\/strong>
Genetic parameters were estimated for prevalences of primary cataract (CAT), persistent pupillary membrane (PPM) and distichiasis (DIST) in 615 single-colored and 617 multi-colored English Cocker Spaniels (ECS) bred in the German kennel club for Spaniels (Jagdspaniel-Klub e. V.). CAT or CAT diagnosed in dogs up to three and a half years of age (early-onset cataract, CAT-early) and CAT diagnosed in dogs over three and a half years of age (late-onset cataract, CAT-late), PPM and DIST were included as binary traits in multivariate genetic analyses. Heritabilities on the underlying liability scale were 0.15 for CAT, 0.34 for CAT-early, 0.13 for CAT-late, 0.46 for PPM, and 0.62 for DIST in single-colored ECS and 0.06 for CAT, 0.13 for CAT-early, 0.14 for CAT-late, 0.10 for PPM, and 0.61 for DIST in multi-colored ECS.There were indications for a different genetic basis of CAT-early and CAT-late in single-colored ECS as genetic correlations were close to zero. In multi-colored ECS, a similar tendency for CAT-early and CAT-late could be observed.


Zusammenfassung<\/strong>
Bei 615 einfarbigen und 617 mehrfarbigen Englischen Cocker Spaniels (ECS) wurden die genetischen Parameter f\u00fcr prim\u00e4re Katarakt (CAT), persistierende Pupillarmembran (PPM) und Distichiasis (DIST) gesch\u00e4tzt. Alle ophthalmologisch untersuchten Hunde wurden im Jagdspaniel-Klub e.V. gez\u00fcchtet. Prim\u00e4re Katarakt insgesamt oder prim\u00e4re Katarakt diagnostiziert bei Hunden bis zum Alter von 3,5 Jahren (fr\u00fch-manifeste Katarakt, CAT-early) und prim\u00e4re Katarakt diagnostiziert bei Hunden mit einem Alter von mehr als 3,5 Jahren (sp\u00e4t-manifeste Katarakt, CAT-late), PPM and DIST wurden als bin\u00e4re Merkmale in den multivariaten genetischen Analysen ber\u00fccksichtigt. Die Heritabilit\u00e4ten betrugen nach Transformation in ein Schwellenwertmodell h2 = 0,15 f\u00fcr die prim\u00e4re Katarakt, 0,34 f\u00fcr die fr\u00fch-manifeste prim\u00e4re Katarakt, 0,13 f\u00fcr die sp\u00e4t-manifeste prim\u00e4re Katarakt, 0,46 f\u00fcr PPM und 0,62 f\u00fcr DIST bei den einfarbigen ECS. Bei den mehrfarbigen ECS lagen die Herita-bilit\u00e4tssch\u00e4tzwerte bei h2 = 0,06 f\u00fcr die prim\u00e4re Katarakt, 0,13 f\u00fcr die fr\u00fch-manifeste prim\u00e4re Katarakt, 0,14 f\u00fcr die sp\u00e4t-manifeste prim\u00e4re Katarakt, 0,10 f\u00fcr PPM und 0,61 f\u00fcr DIST. Da die genetischen Korrelationen bei den einfarbigen ECS nahe bei Null lagen, ist davon auszugehen, dass bei dieser Farbvariante der ECS fr\u00fch-manifeste Katarakt und sp\u00e4t-manifeste Katarakt genetisch unterschiedliche Merkmale darstellen. \u00c4hnliches konnte bei mehrfarbigen ECS f\u00fcr diese beiden sich fr\u00fch und sp\u00e4t im Leben manifestierenden Kataraktformen beobachtet werden.<\/p>","primaryLanguage":"englisch","summary":"Genetic parameters were estimated for prevalences of primary cataract (CAT), persistent pupillary membrane (PPM) and distichiasis (DIST) in 615 single-colored and 617 multi-colored English Cocker Spaniels (ECS) bred in the German kennel club for Spaniels (Jagdspaniel-Klub e. V.). CAT or CAT diagnosed in dogs up to three and a half years of age (early-onset cataract, CAT-early) and CAT diagnosed in dogs over three and a half years of age (late-onset cataract, CAT-late), PPM and DIST were included as binary traits in multivariate genetic analyses. Heritabilities on the underlying liability scale were 0.15 for CAT, 0.34 for CAT-early, 0.13 for CAT-late, 0.46 for PPM, and 0.62 for DIST in single-colored ECS and 0.06 for CAT, 0.13 for CAT-early, 0.14 for CAT-late, 0.10 for PPM, and 0.61 for DIST in multi-colored ECS.There were indications for a different genetic basis of CAT-early and CAT-late in single-colored ECS as genetic correlations were close to zero. In multi-colored ECS, a similar tendency for CAT-early and CAT-late could be observed.","zusammenfassung":"Bei 615 einfarbigen und 617 mehrfarbigen Englischen Cocker Spaniels (ECS) wurden die genetischen Parameter f\u00fcr prim\u00e4re Katarakt (CAT), persistierende Pupillarmembran (PPM) und Distichiasis (DIST) gesch\u00e4tzt. Alle ophthalmologisch untersuchten Hunde wurden im Jagdspaniel-Klub e.V. gez\u00fcchtet. Prim\u00e4re Katarakt insgesamt oder prim\u00e4re Katarakt diagnostiziert bei Hunden bis zum Alter von 3,5 Jahren (fr\u00fch-manifeste Katarakt, CAT-early) und prim\u00e4re Katarakt diagnostiziert bei Hunden mit einem Alter von mehr als 3,5 Jahren (sp\u00e4t-manifeste Katarakt, CAT-late), PPM and DIST wurden als bin\u00e4re Merkmale in den multivariaten genetischen Analysen ber\u00fccksichtigt. Die Heritabilit\u00e4ten betrugen nach Transformation in ein Schwellenwertmodell h2 = 0,15 f\u00fcr die prim\u00e4re Katarakt, 0,34 f\u00fcr die fr\u00fch-manifeste prim\u00e4re Katarakt, 0,13 f\u00fcr die sp\u00e4t-manifeste prim\u00e4re Katarakt, 0,46 f\u00fcr PPM und 0,62 f\u00fcr DIST bei den einfarbigen ECS. Bei den mehrfarbigen ECS lagen die Herita-bilit\u00e4tssch\u00e4tzwerte bei h2 = 0,06 f\u00fcr die prim\u00e4re Katarakt, 0,13 f\u00fcr die fr\u00fch-manifeste prim\u00e4re Katarakt, 0,14 f\u00fcr die sp\u00e4t-manifeste prim\u00e4re Katarakt, 0,10 f\u00fcr PPM und 0,61 f\u00fcr DIST. Da die genetischen Korrelationen bei den einfarbigen ECS nahe bei Null lagen, ist davon auszugehen, dass bei dieser Farbvariante der ECS fr\u00fch-manifeste Katarakt und sp\u00e4t-manifeste Katarakt genetisch unterschiedliche Merkmale darstellen. \u00c4hnliches konnte bei mehrfarbigen ECS f\u00fcr diese beiden sich fr\u00fch und sp\u00e4t im Leben manifestierenden Kataraktformen beobachtet werden.<\/p>","translatedTitle":"DOI 10.2376\/0005-9366-120-490","abstractE":"Genetic parameters were estimated for prevalences of primary cataract (CAT), persistent pupillary membrane (PPM) and distichiasis (DIST) in 615 single-colored and 617 multi-colored English Cocker Spaniels (ECS) bred in the German kennel club for Spaniels (Jagdspaniel-Klub e. V.). CAT or CAT diagnosed in dogs up to three and a half years of age (early-onset cataract, CAT-early) and CAT diagnosed in dogs over three and a half years of age (late-onset cataract, CAT-late), PPM and DIST were included as binary traits in multivariate genetic analyses. Heritabilities on the underlying liability scale were 0.15 for CAT, 0.34 for CAT-early, 0.13 for CAT-late, 0.46 for PPM, and 0.62 for DIST in single-colored ECS and 0.06 for CAT, 0.13 for CAT-early, 0.14 for CAT-late, 0.10 for PPM, and 0.61 for DIST in multi-colored ECS.There were indications for a different genetic basis of CAT-early and CAT-late in single-colored ECS as genetic correlations were close to zero. In multi-colored ECS, a similar tendency for CAT-early and CAT-late could be observed.","date":{"year":2007,"date":"11\/2007","accepted":"2007-11-01"},"volume":"120","openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"490-498","redirects":["21594660\/150\/3130\/70568"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} CY - Hannover DA - 11/2007 DO - 10.2376/0005-9366-120-490 LA - English N2 - Genetic parameters were estimated for prevalences of primary cataract (CAT), persistent pupillary membrane (PPM) and distichiasis (DIST) in 615 single-colored and 617 multi-colored English Cocker Spaniels (ECS) bred in the German kennel club for Spaniels (Jagdspaniel-Klub e. V.). CAT or CAT diagnosed in dogs up to three and a half years of age (early-onset cataract, CAT-early) and CAT diagnosed in dogs over three and a half years of age (late-onset cataract, CAT-late), PPM and DIST were included as binary traits in multivariate genetic analyses. Heritabilities on the underlying liability scale were 0.15 for CAT, 0.34 for CAT-early, 0.13 for CAT-late, 0.46 for PPM, and 0.62 for DIST in single-colored ECS and 0.06 for CAT, 0.13 for CAT-early, 0.14 for CAT-late, 0.10 for PPM, and 0.61 for DIST in multi-colored ECS.There were indications for a different genetic basis of CAT-early and CAT-late in single-colored ECS as genetic correlations were close to zero. In multi-colored ECS, a similar tendency for CAT-early and CAT-late could be observed. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2007 SP - 490 EP - 498 T1 - Analysis of systematic and genetic effects on the prevalence of primary cataract, persistent pupillary membrane and distichiasis in the two color variants of English Cocker Spaniels in Germany T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Analysis of systematic and genetic effects on the prevalence of primary cataract, persistent pupillary membrane and distichiasis in the two color variants of English Cocker Spaniels in Germany TT - DOI 10.2376/0005-9366-120-490 VL - 120 SN - 0005-9366 ER -