TY - JOUR AU - S Fecht AU - O Distl AB - A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs which provoke adverse effects are structurally different. Although they are used for many different indications, all of these drugs are substrates of a transporting protein encoded by the MDR1 gene. This Pglycoprotein loses its normal protecting function at the tissue barriers in dogs with the mdr11. mutation. This article gives a short overview about the present state of analyses regarding the canine MDR1 gene. The genetic background, effects and prevalence in affected dog breeds of the mdr11. mutation are summarized. On the one hand, the overview might help practical veterinarians to understand the aetiology of drug sensitivity in dogs with the mdr11. mutation, and on the other hand, it might point out appendages for future research works about the canine MDR1 gene as well as for breeding strategies in affected dog breeds. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":70314,"title":"Review of prevalence, genetic aspects and adverse effects of the mdr1-1. mutation in dogs","teaserText":"MDR1, mutation, dog, drug sensitivity, MDR1, Mutation, Hund, Arzneimittel\u00fcberempfindlichkeit","content":"

Summary<\/span>
A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs which provoke adverse effects are structurally different. Although they are used for many different indications, all of these drugs are substrates of a transporting protein encoded by the MDR1 gene. This Pglycoprotein loses its normal protecting function at the tissue barriers in dogs with the mdr11. mutation. This article gives a short overview about the present state of analyses regarding the canine MDR1 gene. The genetic background, effects and prevalence in affected dog breeds of the mdr11. mutation are summarized. On the one hand, the overview might help practical veterinarians to understand the aetiology of drug sensitivity in dogs with the mdr11. mutation, and on the other hand, it might point out appendages for future research works about the canine MDR1 gene as well as for breeding strategies in affected dog breeds.


Zusammenfassung<\/span>
Eine Mutation im MDR1Gen des Hundes verursacht bei Collies und den damit verwandten Hunderassen eine multiple Arzneimittel\u00fcberempfindlichkeit. Hunde mit diesem genetischen Defekt zeigen schwere neurotoxische Erscheinungen, wenn sie mit bestimmten Arzneimitteln behandelt werden. Klinische Symptome, die vom verabreichten Medikament und seiner Konzentration abh\u00e4ngen, variieren von milden Vergiftungserscheinungen mit vermehrtem Speichelfluss und Desorientiertheit bis zu starken Auswirkungen mit Koma und schlie\u00dflich Tod des Tieres. Arzneimittel, die Nebenwirkungen verursachen, unterscheiden sich strukturell voneinander. Obwohl sie f\u00fcr viele verschiedene Indikationen benutzt werden, sind alle diese Arzneimittel Substrate des vom MDR1Gen codierten PGlykoproteins, das wichtige Transportfunktionen erf\u00fcllt. Dieses PGlykoprotein verliert bei Hunden mit der mdr11.Mutation seine normale Funktion an Gewebeschranken. Dieser Artikel gibt einen kurzen \u00dcberblick \u00fcber den derzeitigen Stand der Forschung bez\u00fcglich des MDR1Gens des Hundes. Der genetische Hintergrund, Auswirkungen und Vorkommen der mdr11.Mutation in betroffenen Hunderassen werden zusammengefasst. Der \u00dcberblick soll einerseits praktizierenden Tier\u00e4rzten helfen, die \u00c4tiologie der Arzneimittel\u00fcberempfindlichkeit bei Hunden mit der mdr11.Mutation zu verstehen, und andererseits Ans\u00e4tze f\u00fcr zuk\u00fcnftige Forschungsarbeiten \u00fcber das canine MDR1Gen sowie f\u00fcr Zuchtstrategien in betroffenen Rassen aufzeigen. <\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Jun 1, 2008 12:00:00 AM","toDate":"Dec 31, 2050 12:00:00 AM","oldUrls":["http:\/\/vetline.de\/mdr1-mutation-dog-drug-sensitivity\/150\/3130\/70314"],"doiLanguage":"englisch","doiProductFormat":"Online","doiPublisher":"M. & H. Schaper GmbH","doiSerialWorkTitle":"Dtsch.tier\u00e4rztl.Wschr.","doiDocumentUri":"http:\/\/www.vetline.de\/mdr1-mutation-dog-drug-sensitivity\/150\/3130\/70314","doiSource":"Dtsch.tier\u00e4rztl.Wschr. 115: 6, 212-219 (2008)","doiissn":"0341-6593","doiNr":"10.2376\/0341-6593-115-212","doiFirstPage":"212","doiLastPage":"219","doiTransmitted":true,"doiAuthor":"FECHT S, DISTL O","pdf":{"path":"http:\/\/data\/dtw_2008_06_0212.pdf","title":"dtw_2008_06_0212.pdf","description":"Review of prevalence, genetic aspects and adverse effects of the mdr1-1. mutation in dogs

"},"authors":[{"firstName":"F","middleName":"ECHTS","lastName":""},{"firstName":"D","middleName":"ISTLO","lastName":""}],"contentOptimised":"

Summary<\/strong>
A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs which provoke adverse effects are structurally different. Although they are used for many different indications, all of these drugs are substrates of a transporting protein encoded by the MDR1 gene. This Pglycoprotein loses its normal protecting function at the tissue barriers in dogs with the mdr11. mutation. This article gives a short overview about the present state of analyses regarding the canine MDR1 gene. The genetic background, effects and prevalence in affected dog breeds of the mdr11. mutation are summarized. On the one hand, the overview might help practical veterinarians to understand the aetiology of drug sensitivity in dogs with the mdr11. mutation, and on the other hand, it might point out appendages for future research works about the canine MDR1 gene as well as for breeding strategies in affected dog breeds.


Zusammenfassung<\/strong>
Eine Mutation im MDR1Gen des Hundes verursacht bei Collies und den damit verwandten Hunderassen eine multiple Arzneimittel\u00fcberempfindlichkeit. Hunde mit diesem genetischen Defekt zeigen schwere neurotoxische Erscheinungen, wenn sie mit bestimmten Arzneimitteln behandelt werden. Klinische Symptome, die vom verabreichten Medikament und seiner Konzentration abh\u00e4ngen, variieren von milden Vergiftungserscheinungen mit vermehrtem Speichelfluss und Desorientiertheit bis zu starken Auswirkungen mit Koma und schlie\u00dflich Tod des Tieres. Arzneimittel, die Nebenwirkungen verursachen, unterscheiden sich strukturell voneinander. Obwohl sie f\u00fcr viele verschiedene Indikationen benutzt werden, sind alle diese Arzneimittel Substrate des vom MDR1Gen codierten PGlykoproteins, das wichtige Transportfunktionen erf\u00fcllt. Dieses PGlykoprotein verliert bei Hunden mit der mdr11.Mutation seine normale Funktion an Gewebeschranken. Dieser Artikel gibt einen kurzen \u00dcberblick \u00fcber den derzeitigen Stand der Forschung bez\u00fcglich des MDR1Gens des Hundes. Der genetische Hintergrund, Auswirkungen und Vorkommen der mdr11.Mutation in betroffenen Hunderassen werden zusammengefasst. Der \u00dcberblick soll einerseits praktizierenden Tier\u00e4rzten helfen, die \u00c4tiologie der Arzneimittel\u00fcberempfindlichkeit bei Hunden mit der mdr11.Mutation zu verstehen, und andererseits Ans\u00e4tze f\u00fcr zuk\u00fcnftige Forschungsarbeiten \u00fcber das canine MDR1Gen sowie f\u00fcr Zuchtstrategien in betroffenen Rassen aufzeigen. <\/p>","primaryLanguage":"englisch","summary":"A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs which provoke adverse effects are structurally different. Although they are used for many different indications, all of these drugs are substrates of a transporting protein encoded by the MDR1 gene. This Pglycoprotein loses its normal protecting function at the tissue barriers in dogs with the mdr11. mutation. This article gives a short overview about the present state of analyses regarding the canine MDR1 gene. The genetic background, effects and prevalence in affected dog breeds of the mdr11. mutation are summarized. On the one hand, the overview might help practical veterinarians to understand the aetiology of drug sensitivity in dogs with the mdr11. mutation, and on the other hand, it might point out appendages for future research works about the canine MDR1 gene as well as for breeding strategies in affected dog breeds.","zusammenfassung":"Eine Mutation im MDR1Gen des Hundes verursacht bei Collies und den damit verwandten Hunderassen eine multiple Arzneimittel\u00fcberempfindlichkeit. Hunde mit diesem genetischen Defekt zeigen schwere neurotoxische Erscheinungen, wenn sie mit bestimmten Arzneimitteln behandelt werden. Klinische Symptome, die vom verabreichten Medikament und seiner Konzentration abh\u00e4ngen, variieren von milden Vergiftungserscheinungen mit vermehrtem Speichelfluss und Desorientiertheit bis zu starken Auswirkungen mit Koma und schlie\u00dflich Tod des Tieres. Arzneimittel, die Nebenwirkungen verursachen, unterscheiden sich strukturell voneinander. Obwohl sie f\u00fcr viele verschiedene Indikationen benutzt werden, sind alle diese Arzneimittel Substrate des vom MDR1Gen codierten PGlykoproteins, das wichtige Transportfunktionen erf\u00fcllt. Dieses PGlykoprotein verliert bei Hunden mit der mdr11.Mutation seine normale Funktion an Gewebeschranken. Dieser Artikel gibt einen kurzen \u00dcberblick \u00fcber den derzeitigen Stand der Forschung bez\u00fcglich des MDR1Gens des Hundes. Der genetische Hintergrund, Auswirkungen und Vorkommen der mdr11.Mutation in betroffenen Hunderassen werden zusammengefasst. Der \u00dcberblick soll einerseits praktizierenden Tier\u00e4rzten helfen, die \u00c4tiologie der Arzneimittel\u00fcberempfindlichkeit bei Hunden mit der mdr11.Mutation zu verstehen, und andererseits Ans\u00e4tze f\u00fcr zuk\u00fcnftige Forschungsarbeiten \u00fcber das canine MDR1Gen sowie f\u00fcr Zuchtstrategien in betroffenen Rassen aufzeigen. <\/p>","translatedTitle":"MDR1, mutation, dog, drug sensitivity, MDR1, Mutation, Hund, Arzneimittel\u00fcberempfindlichkeit","abstractE":"A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs which provoke adverse effects are structurally different. Although they are used for many different indications, all of these drugs are substrates of a transporting protein encoded by the MDR1 gene. This Pglycoprotein loses its normal protecting function at the tissue barriers in dogs with the mdr11. mutation. This article gives a short overview about the present state of analyses regarding the canine MDR1 gene. The genetic background, effects and prevalence in affected dog breeds of the mdr11. mutation are summarized. On the one hand, the overview might help practical veterinarians to understand the aetiology of drug sensitivity in dogs with the mdr11. mutation, and on the other hand, it might point out appendages for future research works about the canine MDR1 gene as well as for breeding strategies in affected dog breeds.","date":{"year":2008,"date":"06\/2008","accepted":"2008-06-01"},"volume":"115","openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"212-219","redirects":["mdr1-mutation-dog-drug-sensitivity\/150\/3130\/70314"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} CY - Hannover DA - 06/2008 DO - 10.2376/0341-6593-115-212 LA - English N2 - A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs which provoke adverse effects are structurally different. Although they are used for many different indications, all of these drugs are substrates of a transporting protein encoded by the MDR1 gene. This Pglycoprotein loses its normal protecting function at the tissue barriers in dogs with the mdr11. mutation. This article gives a short overview about the present state of analyses regarding the canine MDR1 gene. The genetic background, effects and prevalence in affected dog breeds of the mdr11. mutation are summarized. On the one hand, the overview might help practical veterinarians to understand the aetiology of drug sensitivity in dogs with the mdr11. mutation, and on the other hand, it might point out appendages for future research works about the canine MDR1 gene as well as for breeding strategies in affected dog breeds. PB - M. & H. Schaper GmbH PP - Hannover PY - 2008 SP - 212 EP - 219 T1 - Review of prevalence, genetic aspects and adverse effects of the mdr1-1. mutation in dogs T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Review of prevalence, genetic aspects and adverse effects of the mdr1-1. mutation in dogs TT - MDR1, mutation, dog, drug sensitivity, MDR1, Mutation, Hund, Arzneimittelüberempfindlichkeit VL - 115 SN - 0341-6593 ER -