TY - JOUR AU - H Müller AU - R Johne AB - Rotaviruses, a genus within the family Reoviridae, are among the most important etiological agents of severe diarrhoeal illness in humans and animals worldwide. Their genome, consisting of 11 Segments of double-stranded RNA, is charac-terized by genetic variability including (i) point mutations, (ii) genomic reassort-ment, and (iii) genome rearrangements,thus leading to the considerable diversity of rotaviruses. Animal rotaviruses are regarded as a potential reservoirfor genetic exchange with human rotaviruses.There is now increasing evidence that anima rotaviruses can infect humans, either by direct transmission of the virus or by contributing one or several genes to reassortants with essentially a human strain genetic background. As mixed infections are a prereguisite for reassortment events, cosurveillance of animal and human rotavirus strains will be vital to gain a better understanding of the relationships between cocirculating viruses, as well as assessing any relevant vaccination programs. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":69731,"title":"Rotaviruses: diversity and zoonotic Potential - a brief review","teaserText":"DOI 10.2376\/0005-9366-120-108","content":"

Summary<\/span>
Rotaviruses, a genus within the family Reoviridae, are among the most important etiological agents of severe diarrhoeal illness in humans and animals worldwide. Their genome, consisting of 11 Segments of double-stranded RNA, is charac-terized by genetic variability including (i) point mutations, (ii) genomic reassort-ment, and (iii) genome rearrangements,thus leading to the considerable diversity of rotaviruses. Animal rotaviruses are regarded as a potential reservoirfor genetic exchange with human rotaviruses.There is now increasing evidence that anima rotaviruses can infect humans, either by direct transmission of the virus or by contributing one or several genes to reassortants with essentially a human strain genetic background. As mixed infections are a prereguisite for reassortment events, cosurveillance of animal and human rotavirus strains will be vital to gain a better understanding of the relationships between cocirculating viruses, as well as assessing any relevant vaccination programs.


Zusammenfassung<\/span>
Rotaviren, ein Genus der Familie Reoviridae, z\u00e4hlen bei Mensch und Tier weltweit zu den wichtigsten Erregern von Durchfallerkrankungen. Ihr Genom,eine segmentierte, doppelstr\u00e4ngige RNA,zeichnet sich durch eine gro\u00dfe genetische Variabilit\u00e4t aus, die durch (i) Punktmutationen, (ii) Neuverteilung genetischer nformation (reassortment) und (iii) Umlagerung genetischer Information (rearrangement) zu einer betr\u00e4chtlichen Vielfalt der Rotaviren f\u00fchrt. Die Rotaviren der Tiere werden als potentielles Reservoir f\u00fcr die genetische Vielfalt der humanen Rotaviren erachtet. In letzter Zeit mehren sich die Hinweise daf\u00fcr, dass Rotaviren von Tieren auch den Menschen infizieren k\u00f6nnen, entweder durch direkte Virus\u00fcbertragung, oder indem eines oder mehrere Gene in Reassortanten eingebaut werdenderen restliche Genomsegmente von Rotaviren des Menschen stammen. Da Doppelinfektionen eine Voraussetzung f\u00fcr die Entstehung von Reassortanten sind, ist auch im Hinblick auf Impfprogramme die gleichzeitige \u00dcberwachung von Rotaviren in Tierbest\u00e4nden und der sie betreuenden Menschen von wesentlicher Bedeutung f\u00fcr die Aufkl\u00e4rung der Verwandtschaftsbeziehungen zwischen den cozirkulierenden Viren.<\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Mar 1, 2007 12:00:00 AM","toDate":"Jan 1, 2030 12:00:00 AM","oldUrls":["http:\/\/vetline.de\/12964258\/150\/3130\/69731"],"doiLanguage":"englisch","doiProductFormat":"Online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl. M\u00fcnch. Tier\u00e4rztl. Wschr.","doiDocumentUri":"http:\/\/www.vetline.de\/12964258\/150\/3130\/69731","doiSource":"Berl. M\u00fcnch. Tier\u00e4rztl. Wschr. 120: 3-4, 108-112 (2007)","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-120-108","doiFirstPage":"108","doiLastPage":"112","doiTransmitted":true,"doiAuthor":"M\u00fcller H, Johne R","pdf":{"path":"http:\/\/data\/bmtw_2007_03_0108.pdf","title":"bmtw_2007_03_0108.pdf","description":"Rotaviruses: diversity and zoonotic Potential - a brief review

"},"authors":[{"firstName":"H","middleName":"","lastName":"M\u00fcller"},{"firstName":"R","middleName":"","lastName":"Johne"}],"contentOptimised":"

Summary<\/strong>
Rotaviruses, a genus within the family Reoviridae, are among the most important etiological agents of severe diarrhoeal illness in humans and animals worldwide. Their genome, consisting of 11 Segments of double-stranded RNA, is charac-terized by genetic variability including (i) point mutations, (ii) genomic reassort-ment, and (iii) genome rearrangements,thus leading to the considerable diversity of rotaviruses. Animal rotaviruses are regarded as a potential reservoirfor genetic exchange with human rotaviruses.There is now increasing evidence that anima rotaviruses can infect humans, either by direct transmission of the virus or by contributing one or several genes to reassortants with essentially a human strain genetic background. As mixed infections are a prereguisite for reassortment events, cosurveillance of animal and human rotavirus strains will be vital to gain a better understanding of the relationships between cocirculating viruses, as well as assessing any relevant vaccination programs.


Zusammenfassung<\/strong>
Rotaviren, ein Genus der Familie Reoviridae, z\u00e4hlen bei Mensch und Tier weltweit zu den wichtigsten Erregern von Durchfallerkrankungen. Ihr Genom,eine segmentierte, doppelstr\u00e4ngige RNA,zeichnet sich durch eine gro\u00dfe genetische Variabilit\u00e4t aus, die durch (i) Punktmutationen, (ii) Neuverteilung genetischer nformation (reassortment) und (iii) Umlagerung genetischer Information (rearrangement) zu einer betr\u00e4chtlichen Vielfalt der Rotaviren f\u00fchrt. Die Rotaviren der Tiere werden als potentielles Reservoir f\u00fcr die genetische Vielfalt der humanen Rotaviren erachtet. In letzter Zeit mehren sich die Hinweise daf\u00fcr, dass Rotaviren von Tieren auch den Menschen infizieren k\u00f6nnen, entweder durch direkte Virus\u00fcbertragung, oder indem eines oder mehrere Gene in Reassortanten eingebaut werdenderen restliche Genomsegmente von Rotaviren des Menschen stammen. Da Doppelinfektionen eine Voraussetzung f\u00fcr die Entstehung von Reassortanten sind, ist auch im Hinblick auf Impfprogramme die gleichzeitige \u00dcberwachung von Rotaviren in Tierbest\u00e4nden und der sie betreuenden Menschen von wesentlicher Bedeutung f\u00fcr die Aufkl\u00e4rung der Verwandtschaftsbeziehungen zwischen den cozirkulierenden Viren.<\/p>","primaryLanguage":"englisch","summary":"Rotaviruses, a genus within the family Reoviridae, are among the most important etiological agents of severe diarrhoeal illness in humans and animals worldwide. Their genome, consisting of 11 Segments of double-stranded RNA, is charac-terized by genetic variability including (i) point mutations, (ii) genomic reassort-ment, and (iii) genome rearrangements,thus leading to the considerable diversity of rotaviruses. Animal rotaviruses are regarded as a potential reservoirfor genetic exchange with human rotaviruses.There is now increasing evidence that anima rotaviruses can infect humans, either by direct transmission of the virus or by contributing one or several genes to reassortants with essentially a human strain genetic background. As mixed infections are a prereguisite for reassortment events, cosurveillance of animal and human rotavirus strains will be vital to gain a better understanding of the relationships between cocirculating viruses, as well as assessing any relevant vaccination programs.","zusammenfassung":"Rotaviren, ein Genus der Familie Reoviridae, z\u00e4hlen bei Mensch und Tier weltweit zu den wichtigsten Erregern von Durchfallerkrankungen. Ihr Genom,eine segmentierte, doppelstr\u00e4ngige RNA,zeichnet sich durch eine gro\u00dfe genetische Variabilit\u00e4t aus, die durch (i) Punktmutationen, (ii) Neuverteilung genetischer nformation (reassortment) und (iii) Umlagerung genetischer Information (rearrangement) zu einer betr\u00e4chtlichen Vielfalt der Rotaviren f\u00fchrt. Die Rotaviren der Tiere werden als potentielles Reservoir f\u00fcr die genetische Vielfalt der humanen Rotaviren erachtet. In letzter Zeit mehren sich die Hinweise daf\u00fcr, dass Rotaviren von Tieren auch den Menschen infizieren k\u00f6nnen, entweder durch direkte Virus\u00fcbertragung, oder indem eines oder mehrere Gene in Reassortanten eingebaut werdenderen restliche Genomsegmente von Rotaviren des Menschen stammen. Da Doppelinfektionen eine Voraussetzung f\u00fcr die Entstehung von Reassortanten sind, ist auch im Hinblick auf Impfprogramme die gleichzeitige \u00dcberwachung von Rotaviren in Tierbest\u00e4nden und der sie betreuenden Menschen von wesentlicher Bedeutung f\u00fcr die Aufkl\u00e4rung der Verwandtschaftsbeziehungen zwischen den cozirkulierenden Viren.<\/p>","translatedTitle":"DOI 10.2376\/0005-9366-120-108","abstractE":"Rotaviruses, a genus within the family Reoviridae, are among the most important etiological agents of severe diarrhoeal illness in humans and animals worldwide. Their genome, consisting of 11 Segments of double-stranded RNA, is charac-terized by genetic variability including (i) point mutations, (ii) genomic reassort-ment, and (iii) genome rearrangements,thus leading to the considerable diversity of rotaviruses. Animal rotaviruses are regarded as a potential reservoirfor genetic exchange with human rotaviruses.There is now increasing evidence that anima rotaviruses can infect humans, either by direct transmission of the virus or by contributing one or several genes to reassortants with essentially a human strain genetic background. As mixed infections are a prereguisite for reassortment events, cosurveillance of animal and human rotavirus strains will be vital to gain a better understanding of the relationships between cocirculating viruses, as well as assessing any relevant vaccination programs.","date":{"year":2007,"date":"03\/2007","accepted":"2007-03-01"},"volume":"120","openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"108-112","redirects":["12964258\/150\/3130\/69731"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} CY - Hannover DA - 03/2007 DO - 10.2376/0005-9366-120-108 LA - English N2 - Rotaviruses, a genus within the family Reoviridae, are among the most important etiological agents of severe diarrhoeal illness in humans and animals worldwide. Their genome, consisting of 11 Segments of double-stranded RNA, is charac-terized by genetic variability including (i) point mutations, (ii) genomic reassort-ment, and (iii) genome rearrangements,thus leading to the considerable diversity of rotaviruses. Animal rotaviruses are regarded as a potential reservoirfor genetic exchange with human rotaviruses.There is now increasing evidence that anima rotaviruses can infect humans, either by direct transmission of the virus or by contributing one or several genes to reassortants with essentially a human strain genetic background. As mixed infections are a prereguisite for reassortment events, cosurveillance of animal and human rotavirus strains will be vital to gain a better understanding of the relationships between cocirculating viruses, as well as assessing any relevant vaccination programs. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2007 SP - 108 EP - 112 T1 - Rotaviruses: diversity and zoonotic Potential - a brief review T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Rotaviruses: diversity and zoonotic Potential - a brief review TT - DOI 10.2376/0005-9366-120-108 VL - 120 SN - 0005-9366 ER -