TY - JOUR KW - Positron-Emission-Tomography (PET) KW - animal model KW - molecular imaging KW - preclinical imaging KW - concept of 3R AU - M Hoffmann AU - H Wieler AU - H-G Buchholz AU - S Pektor AU - M Schreckenberger AB - Positron-emission-tomography (PET) is a nuclear imaging technique that permits the spatial and temporal distribution of compounds labeled with a positronemitting radionuclide to be determined noninvasively. Positron-labeled compounds (tracers) have been synthesized to target a range of specific markers and pathways. Small animal PET (i.e. mice, rats, hamsters) has undergone a major evolution. This has been driven by technical improvements and increasing interest of pharmaceutical companies. The focus of the method has shifted towards the quantification of the physiological parameters necessary to use this technique for kinetic modeling of tracers. Methods for minimising the number of animals used for experiments and minimising animal suffering have to be considered (concept of 3R: replacement, reduction and refinement) to provide more humane animal research. In this review, we will give an overview of how the technique can be used to study diseases, to evaluate therapies or new drugs and to gain inside into molecular processes in vivo. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":110648,"title":"Challenges and chances of preclinical and animal experimental PET imaging","topline":"","teaserText":"Herausforderungen und M\u00f6glichkeiten der pr\u00e4klinischen und tierexperimentellen PET-Bildgebung","content":"

Summary<\/span>
Positron-emission-tomography (PET) is a nuclear imaging technique that permits the spatial and temporal distribution of compounds labeled with a positronemitting radionuclide to be determined noninvasively. Positron-labeled compounds (tracers) have been synthesized to target a range of specific markers and pathways. Small animal PET (i.e. mice, rats, hamsters) has undergone a major evolution. This has been driven by technical improvements and increasing interest of pharmaceutical companies. The focus of the method has shifted towards the quantification of the physiological parameters necessary to use this technique for kinetic modeling of tracers. Methods for minimising the number of animals used for experiments and minimising animal suffering have to be considered (concept of 3R: replacement, reduction and refinement) to provide more humane animal research. In this review, we will give an overview of how the technique can be used to study diseases, to evaluate therapies or new drugs and to gain inside into molecular processes in vivo.<\/p>

Keywords<\/span>
Positron-Emission-Tomography (PET), animal model, molecular imaging, preclinical imaging, concept of 3R<\/p>

Zusammenfassung<\/span>
Die Positronen-Emissions-Tomografie (PET) ist eine nukleare Bildgebungstechnik, mit der die r\u00e4umliche und zeitliche Verteilung von Verbindungen, die mit einem Positronen-emittierenden Radionuklid markiert sind, nichtinvasiv bestimmt werden kann. Positronen-markierte Verbindungen (Tracer) wurden synthetisiert, um auf eine Reihe spezifischer Marker und Signalwege zu zielen. Die Bildgebung von kleinen Tieren (z. B. M\u00e4use, Ratten, Hamster) mit PET hat eine bedeutende Entwicklung durchlaufen. Dies wurde durch technische Verbesserungen und zunehmendes Interesse der Pharmaunternehmen betrieben. Der Fokus der Methode hat sich auf die Quantifizierung der physiologischen Parameter verlagert, die zur Verwendung dieser Technik f\u00fcr die kinetische Modellierung von Tracern erforderlich sind. Methoden zur Minimierung der Anzahl der f\u00fcr Versuche verwendeten Tiere und zur Minimierung des Leidens der Tiere m\u00fcssen ber\u00fccksichtigt werden (3R-Konzept: Replacement, Reduction und Refinement), um eine humanere Tierforschung zu gew\u00e4hrleisten. In dieser Arbeit geben wir einen \u00dcberblick dar\u00fcber, wie die Technik verwendet werden kann, um Krankheiten zu untersuchen, Therapien oder neue Medikamente zu bewerten und in vivo in molekulare Prozesse Einblick zu gewinnen.<\/p>

Schl\u00fcsselw\u00f6rter<\/span>
Positronen-Emissions-Tomografie (PET), Tiermodell, molekulare Bildgebung, pr\u00e4klinische Bildgebung, 3R-Konzept<\/p>","categories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"],"fromDate":"Mar 6, 2019 1:32:12 PM","oldUrls":["http:\/\/vetline.de\/challenges-and-chances-of-preclinical-and-animal-experimental-pet-imaging\/150\/3216\/110648","http:\/\/vetline.de\/challenges-and-chances-of-preclinical-and-animal-experimental-pet-imaging\/150\/3130\/110648"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl M\u00fcnch Tier\u00e4rztl Wochensch","doiDocumentUri":"https:\/\/vetline.de\/files\/smfiledata\/7\/4\/9\/5\/1\/4\/BMTW_OA_18085_Hoffmann.pdf","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochenschc","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-18085","doiFirstPage":".","doiLastPage":"..","doiTransmitted":true,"doiAuthor":"Hoffmann MA, Wieler HJ, Buchholz HG, Pektor S, Schreckenberger M","pdf":{"path":"http:\/\/data\/BMTW_OA_18085_Hoffmann.pdf","title":"BMTW_OA_18085_Hoffmann","description":"Challenges and chances of preclinical and animal experimental PET imaging"},"authors":[{"firstName":"M","middleName":"A","lastName":"Hoffmann"},{"firstName":"H","middleName":"J","lastName":"Wieler"},{"firstName":"H","middleName":"G","lastName":"Buchholz"},{"firstName":"S","middleName":"","lastName":"Pektor"},{"firstName":"M","middleName":"","lastName":"Schreckenberger"}],"contentOptimised":"

Summary<\/strong>
Positron-emission-tomography (PET) is a nuclear imaging technique that permits the spatial and temporal distribution of compounds labeled with a positronemitting radionuclide to be determined noninvasively. Positron-labeled compounds (tracers) have been synthesized to target a range of specific markers and pathways. Small animal PET (i.e. mice, rats, hamsters) has undergone a major evolution. This has been driven by technical improvements and increasing interest of pharmaceutical companies. The focus of the method has shifted towards the quantification of the physiological parameters necessary to use this technique for kinetic modeling of tracers. Methods for minimising the number of animals used for experiments and minimising animal suffering have to be considered (concept of 3R: replacement, reduction and refinement) to provide more humane animal research. In this review, we will give an overview of how the technique can be used to study diseases, to evaluate therapies or new drugs and to gain inside into molecular processes in vivo.<\/p>

Keywords:<\/strong>
Positron-Emission-Tomography (PET), animal model, molecular imaging, preclinical imaging, concept of 3R<\/p>

Zusammenfassung<\/strong>
Die Positronen-Emissions-Tomografie (PET) ist eine nukleare Bildgebungstechnik, mit der die r\u00e4umliche und zeitliche Verteilung von Verbindungen, die mit einem Positronen-emittierenden Radionuklid markiert sind, nichtinvasiv bestimmt werden kann. Positronen-markierte Verbindungen (Tracer) wurden synthetisiert, um auf eine Reihe spezifischer Marker und Signalwege zu zielen. Die Bildgebung von kleinen Tieren (z. B. M\u00e4use, Ratten, Hamster) mit PET hat eine bedeutende Entwicklung durchlaufen. Dies wurde durch technische Verbesserungen und zunehmendes Interesse der Pharmaunternehmen betrieben. Der Fokus der Methode hat sich auf die Quantifizierung der physiologischen Parameter verlagert, die zur Verwendung dieser Technik f\u00fcr die kinetische Modellierung von Tracern erforderlich sind. Methoden zur Minimierung der Anzahl der f\u00fcr Versuche verwendeten Tiere und zur Minimierung des Leidens der Tiere m\u00fcssen ber\u00fccksichtigt werden (3R-Konzept: Replacement, Reduction und Refinement), um eine humanere Tierforschung zu gew\u00e4hrleisten. In dieser Arbeit geben wir einen \u00dcberblick dar\u00fcber, wie die Technik verwendet werden kann, um Krankheiten zu untersuchen, Therapien oder neue Medikamente zu bewerten und in vivo in molekulare Prozesse Einblick zu gewinnen.<\/p>

Schl\u00fcsselw\u00f6rter:<\/strong>
Positronen-Emissions-Tomografie (PET), Tiermodell, molekulare Bildgebung, pr\u00e4klinische Bildgebung, 3R-Konzept<\/p>","primaryLanguage":"englisch","summary":"Positron-emission-tomography (PET) is a nuclear imaging technique that permits the spatial and temporal distribution of compounds labeled with a positronemitting radionuclide to be determined noninvasively. Positron-labeled compounds (tracers) have been synthesized to target a range of specific markers and pathways. Small animal PET (i.e. mice, rats, hamsters) has undergone a major evolution. This has been driven by technical improvements and increasing interest of pharmaceutical companies. The focus of the method has shifted towards the quantification of the physiological parameters necessary to use this technique for kinetic modeling of tracers. Methods for minimising the number of animals used for experiments and minimising animal suffering have to be considered (concept of 3R: replacement, reduction and refinement) to provide more humane animal research. In this review, we will give an overview of how the technique can be used to study diseases, to evaluate therapies or new drugs and to gain inside into molecular processes in vivo.<\/p>

","keywords":["Positron-Emission-Tomography (PET)","animal model","molecular imaging","preclinical imaging","concept of 3R"],"zusammenfassung":"Die Positronen-Emissions-Tomografie (PET) ist eine nukleare Bildgebungstechnik, mit der die r\u00e4umliche und zeitliche Verteilung von Verbindungen, die mit einem Positronen-emittierenden Radionuklid markiert sind, nichtinvasiv bestimmt werden kann. Positronen-markierte Verbindungen (Tracer) wurden synthetisiert, um auf eine Reihe spezifischer Marker und Signalwege zu zielen. Die Bildgebung von kleinen Tieren (z. B. M\u00e4use, Ratten, Hamster) mit PET hat eine bedeutende Entwicklung durchlaufen. Dies wurde durch technische Verbesserungen und zunehmendes Interesse der Pharmaunternehmen betrieben. Der Fokus der Methode hat sich auf die Quantifizierung der physiologischen Parameter verlagert, die zur Verwendung dieser Technik f\u00fcr die kinetische Modellierung von Tracern erforderlich sind. Methoden zur Minimierung der Anzahl der f\u00fcr Versuche verwendeten Tiere und zur Minimierung des Leidens der Tiere m\u00fcssen ber\u00fccksichtigt werden (3R-Konzept: Replacement, Reduction und Refinement), um eine humanere Tierforschung zu gew\u00e4hrleisten. In dieser Arbeit geben wir einen \u00dcberblick dar\u00fcber, wie die Technik verwendet werden kann, um Krankheiten zu untersuchen, Therapien oder neue Medikamente zu bewerten und in vivo in molekulare Prozesse Einblick zu gewinnen.<\/p>

","schluesselwoerter":["Positronen-Emissions-Tomografie (PET)","Tiermodell","molekulare Bildgebung","pr\u00e4klinische Bildgebung","3R-Konzept"],"translatedTitle":"Herausforderungen und M\u00f6glichkeiten der pr\u00e4klinischen und tierexperimentellen PET-Bildgebung","abstractE":"Positron-emission-tomography (PET) is a nuclear imaging technique that permits the spatial and temporal distribution of compounds labeled with a positronemitting radionuclide to be determined noninvasively. Positron-labeled compounds (tracers) have been synthesized to target a range of specific markers and pathways. Small animal PET (i.e. mice, rats, hamsters) has undergone a major evolution. This has been driven by technical improvements and increasing interest of pharmaceutical companies. The focus of the method has shifted towards the quantification of the physiological parameters necessary to use this technique for kinetic modeling of tracers. Methods for minimising the number of animals used for experiments and minimising animal suffering have to be considered (concept of 3R: replacement, reduction and refinement) to provide more humane animal research. In this review, we will give an overview of how the technique can be used to study diseases, to evaluate therapies or new drugs and to gain inside into molecular processes in vivo.","date":{"year":2019,"date":"03\/2019","accepted":"2019-03-06"},"volume":132,"openAccess":true,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"","redirects":["challenges-and-chances-of-preclinical-and-animal-experimental-pet-imaging\/150\/3216\/110648","challenges-and-chances-of-preclinical-and-animal-experimental-pet-imaging\/150\/3130\/110648"],"tierartCategories":[],"artikelartCategories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"]} CY - Hannover DA - 03/2019 DO - 10.2376/0005-9366-18085 LA - English N2 - Positron-emission-tomography (PET) is a nuclear imaging technique that permits the spatial and temporal distribution of compounds labeled with a positronemitting radionuclide to be determined noninvasively. Positron-labeled compounds (tracers) have been synthesized to target a range of specific markers and pathways. Small animal PET (i.e. mice, rats, hamsters) has undergone a major evolution. This has been driven by technical improvements and increasing interest of pharmaceutical companies. The focus of the method has shifted towards the quantification of the physiological parameters necessary to use this technique for kinetic modeling of tracers. Methods for minimising the number of animals used for experiments and minimising animal suffering have to be considered (concept of 3R: replacement, reduction and refinement) to provide more humane animal research. In this review, we will give an overview of how the technique can be used to study diseases, to evaluate therapies or new drugs and to gain inside into molecular processes in vivo. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2019 T1 - Challenges and chances of preclinical and animal experimental PET imaging T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Challenges and chances of preclinical and animal experimental PET imaging TT - Herausforderungen und Möglichkeiten der präklinischen und tierexperimentellen PET-Bildgebung VL - 132 SN - 0005-9366 ER -