TY - JOUR
KW - Campylobacter jejuni
KW - adherence
KW - invasion
AU - R Lugert
AU - U Groß
AU - A Zautner
AB -  Campylobacter (C.) jejuni is the most important reported cause for bacterial diarrhoea.  The infection can be accompanied by fever and abdominal cramps and  in rare cases the Guillain-Barré syndrome or reactive arthritis can develop as a  post-infection complication. Several biological properties of C. jejuni, e. g. motility  and chemotaxis, contribute to the biological fitness of the pathogen. For this,  deficiencies in the function of these features clearly reduce the pathogenicity of  C. jejuni without being a virulence factor per se.  Opposing to this, there are two essential requirements to determine the virulence  of C. jejuni which represent the adherence to, and the invasion of host cells.  Thereby, adherence, as a virulence factor, is mediated by many different bacterialderived  components like proteins but also by several oligo- and polysaccharide  structures that are linked to surface proteins but also to the flagella.  In addition, several invasion-relevant features of C. jejuni have been detected so  far. Whereas some of them are described functionally to modulate cytoskeleton  arrangement of the host cell, others are only described as invasion relevant.  Indeed, investigations with respect to the pathogenic potential of some adherence-  and invasion-relevant components did not give identical results indicating  that their relevance might depend on the interplay of the respective C. jejuni  strains used in these studies with the corresponding host cells.  This review summarizes the C. jejuni components for adherence to and invasion  of host cells together with their particular mode of action if known.
BT - Berliner und Münchener Tierärztliche Wochenschrift
C1 - {"oldId":84283,"title":"Campylobacter jejuni: Components for adherence to and invasion of eukaryotic cells","topline":"Open Access | CARO-Themenheft","teaserText":"Campylobacter jejuni: Faktoren f\u00fcr Adh\u00e4renz an und Invasion von Eukaryontenzellen","content":"<p> <span class=\"bold\">Summary<\/span><\/p><p> <span class=\"italic\">Campylobacter <\/span><span class=\"italic\">(C.)<\/span> <span class=\"italic\">jejuni<\/span> is the most important reported cause for bacterial diarrhoea.  The infection can be accompanied by fever and abdominal cramps and  in rare cases the Guillain-Barr\u00e9 syndrome or reactive arthritis can develop as a  post-infection complication. Several biological properties of <span class=\"italic\">C. jejuni<\/span>, e. g. motility  and chemotaxis, contribute to the biological fitness of the pathogen. For this,  deficiencies in the function of these features clearly reduce the pathogenicity of  <span class=\"italic\">C. jejuni<\/span> without being a virulence factor per se.  Opposing to this, there are two essential requirements to determine the virulence  of <span class=\"italic\">C. jejuni<\/span> which represent the adherence to, and the invasion of host cells.  Thereby, adherence, as a virulence factor, is mediated by many different bacterialderived  components like proteins but also by several oligo- and polysaccharide  structures that are linked to surface proteins but also to the flagella.  In addition, several invasion-relevant features of <span class=\"italic\">C. jejuni<\/span> have been detected so  far. Whereas some of them are described functionally to modulate cytoskeleton  arrangement of the host cell, others are only described as invasion relevant.  Indeed, investigations with respect to the pathogenic potential of some adherence-  and invasion-relevant components did not give identical results indicating  that their relevance might depend on the interplay of the respective <span class=\"italic\">C. jejuni<\/span>  strains used in these studies with the corresponding host cells.  This review summarizes the<span class=\"italic\"> C. jejuni<\/span> components for adherence to and invasion  of host cells together with their particular mode of action if known.<br \/><\/p><p> <span class=\"bold\">Keywords<\/span><\/p><p> <span class=\"italic\">Campylobacter jejuni<\/span>, adherence, invasion<\/p><p><span class=\"bold\">Zusammenfassung<\/span><\/p><p> <span class=\"italic\">Campylobacter <\/span><span class=\"italic\">(C.)<\/span><span class=\"italic\"> jejuni<\/span> ist der wichtigste gemeldete Erreger der bakteriellen  Diarrhoe. Neben den klassischen Durchfallsymptomen, einschlie\u00dflich Fieber und  abdominellen Kr\u00e4mpfen, k\u00f6nnen sich das Guillain-Barr\u00e9 Syndrom, aber auch  reaktive Arthritis im Anschluss an das infekti\u00f6se Geschehen einstellen. Verschiedene  Eigenschaften von <span class=\"italic\">C. jejuni<\/span>, wie z. B. die Motilit\u00e4t aber auch Chemotaxis,  tragen zur biologischen Fitness des Erregers entscheidend bei. Einschr\u00e4nkungen  dieser F\u00e4higkeiten reduzieren die Pathogenit\u00e4t  von<span class=\"italic\"> C. jejuni<\/span>, ohne dabei per se als  Virulenzfaktoren gelten zu k\u00f6nnen.  Im Gegensatz hierzu stehen Faktoren des Erregers, die vor allem seine Virulenz  bestimmen, wie z. B. die Adh\u00e4renz an und die Invasion in Wirtszellen. Die Adh\u00e4renzeigenschaften  werden von verschiedenen bakteriellen Komponenten, wie  beispielsweise Proteinen, aber auch Oligo- und Polysaccharidstrukturen, welche  Protein-, aber auch Flagellar-gebunden sind, bestimmt. Zus\u00e4tzlich sind verschiedene  invasionsrelevante Komponenten von <span class=\"italic\">C. jejuni <\/span>bekannt. W\u00e4hrend von  einigen dieser Invasionsfaktoren gezeigt werden konnte, dass sie die Zytoskelettstruktur  der Wirtszelle ver\u00e4ndern, sind andere lediglich als invasionsrelevant<br \/> beschrieben. Allerdings sind die Forschungsergebnisse im Hinblick auf die Bedeutung einiger Adh\u00e4renz- aber auch Invasionsfaktoren nicht einheitlich, was darauf  hinweisen k\u00f6nnte, dass die Funktion dieser Faktoren an den jeweiligen  <span class=\"italic\">C. jejuni<\/span>-Stamm und die eingesetzte Wirtszelllinie gebunden ist.  Diese \u00dcbersichtsarbeit fasst die Faktoren von <span class=\"italic\">C. jejuni<\/span> zusammen, welche die  Adh\u00e4renz an und die Invasion in Wirtszellen vermitteln. Der jeweilige Wirkungsmechanismus  der relevanten Proteine wird, soweit bekannt, beschrieben.<\/p><p> <span class=\"bold\">Schl\u00fcsselw\u00f6rter<\/span><\/p><p> <span class=\"italic\">Campylobacter jejuni<\/span>, Adh\u00e4renz, Invasion <\/p>","categories":["Open Access","Abostufe frei"],"fromDate":"Dec 17, 2014 10:50:16 AM","oldUrls":["http:\/\/vetline.de\/campylobacter-jejuni-components-for-adherence-to-and-invasion-of-eukaryotic-cells\/150\/3216\/84283"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr","doiDocumentUri":"http:\/\/cf01.vetline.schluetersche.de\/files\/smfiledata\/4\/3\/1\/7\/8\/2\/BMW_2015_Caro_14084_Lugert_onl300.pdf","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochenschr 128, 90\u201397","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-128-90","doiFirstPage":"90","doiLastPage":"97","doiTransmitted":true,"doiAuthor":"Lugert R, Gro\u00df U, Zautner AE ","pdf":{"path":"http:\/\/data\/BMW_2015_0090.pdf","title":"BMW_2015_0090.pdf","description":"Campylobacter jejuni: Components for adherence to and invasion of eukaryotic cells"},"authors":[{"firstName":"R","middleName":"","lastName":"Lugert"},{"firstName":"U","middleName":"","lastName":"Gro\u00df"},{"firstName":"A","middleName":"E","lastName":"Zautner"}],"contentOptimised":"<p> <strong>Summary<\/strong><\/p><p> <em>Campylobacter <\/em><em>(C.)<\/em> <em>jejuni<\/em> is the most important reported cause for bacterial diarrhoea.  The infection can be accompanied by fever and abdominal cramps and  in rare cases the Guillain-Barr\u00e9 syndrome or reactive arthritis can develop as a  post-infection complication. Several biological properties of <em>C. jejuni<\/em>, e. g. motility  and chemotaxis, contribute to the biological fitness of the pathogen. For this,  deficiencies in the function of these features clearly reduce the pathogenicity of  <em>C. jejuni<\/em> without being a virulence factor per se.  Opposing to this, there are two essential requirements to determine the virulence  of <em>C. jejuni<\/em> which represent the adherence to, and the invasion of host cells.  Thereby, adherence, as a virulence factor, is mediated by many different bacterialderived  components like proteins but also by several oligo- and polysaccharide  structures that are linked to surface proteins but also to the flagella.  In addition, several invasion-relevant features of <em>C. jejuni<\/em> have been detected so  far. Whereas some of them are described functionally to modulate cytoskeleton  arrangement of the host cell, others are only described as invasion relevant.  Indeed, investigations with respect to the pathogenic potential of some adherence-  and invasion-relevant components did not give identical results indicating  that their relevance might depend on the interplay of the respective <em>C. jejuni<\/em>  strains used in these studies with the corresponding host cells.  This review summarizes the<em> C. jejuni<\/em> components for adherence to and invasion  of host cells together with their particular mode of action if known.<br><\/p><p> <strong>Keywords:<\/strong><\/p><p> <em>Campylobacter jejuni<\/em>, adherence, invasion<\/p><p><strong>Zusammenfassung<\/strong><\/p><p> <em>Campylobacter <\/em><em>(C.)<\/em><em> jejuni<\/em> ist der wichtigste gemeldete Erreger der bakteriellen  Diarrhoe. Neben den klassischen Durchfallsymptomen, einschlie\u00dflich Fieber und  abdominellen Kr\u00e4mpfen, k\u00f6nnen sich das Guillain-Barr\u00e9 Syndrom, aber auch  reaktive Arthritis im Anschluss an das infekti\u00f6se Geschehen einstellen. Verschiedene  Eigenschaften von <em>C. jejuni<\/em>, wie z. B. die Motilit\u00e4t aber auch Chemotaxis,  tragen zur biologischen Fitness des Erregers entscheidend bei. Einschr\u00e4nkungen  dieser F\u00e4higkeiten reduzieren die Pathogenit\u00e4t  von<em> C. jejuni<\/em>, ohne dabei per se als  Virulenzfaktoren gelten zu k\u00f6nnen.  Im Gegensatz hierzu stehen Faktoren des Erregers, die vor allem seine Virulenz  bestimmen, wie z. B. die Adh\u00e4renz an und die Invasion in Wirtszellen. Die Adh\u00e4renzeigenschaften  werden von verschiedenen bakteriellen Komponenten, wie  beispielsweise Proteinen, aber auch Oligo- und Polysaccharidstrukturen, welche  Protein-, aber auch Flagellar-gebunden sind, bestimmt. Zus\u00e4tzlich sind verschiedene  invasionsrelevante Komponenten von <em>C. jejuni <\/em>bekannt. W\u00e4hrend von  einigen dieser Invasionsfaktoren gezeigt werden konnte, dass sie die Zytoskelettstruktur  der Wirtszelle ver\u00e4ndern, sind andere lediglich als invasionsrelevant<br> beschrieben. Allerdings sind die Forschungsergebnisse im Hinblick auf die Bedeutung einiger Adh\u00e4renz- aber auch Invasionsfaktoren nicht einheitlich, was darauf  hinweisen k\u00f6nnte, dass die Funktion dieser Faktoren an den jeweiligen  <em>C. jejuni<\/em>-Stamm und die eingesetzte Wirtszelllinie gebunden ist.  Diese \u00dcbersichtsarbeit fasst die Faktoren von <em>C. jejuni<\/em> zusammen, welche die  Adh\u00e4renz an und die Invasion in Wirtszellen vermitteln. Der jeweilige Wirkungsmechanismus  der relevanten Proteine wird, soweit bekannt, beschrieben.<\/p><p> <strong>Schl\u00fcsselw\u00f6rter:<\/strong><\/p><p> <em>Campylobacter jejuni<\/em>, Adh\u00e4renz, Invasion <\/p>","primaryLanguage":"englisch","summary":"<\/p><p> <em>Campylobacter <\/em><em>(C.)<\/em> <em>jejuni<\/em> is the most important reported cause for bacterial diarrhoea.  The infection can be accompanied by fever and abdominal cramps and  in rare cases the Guillain-Barr\u00e9 syndrome or reactive arthritis can develop as a  post-infection complication. Several biological properties of <em>C. jejuni<\/em>, e. g. motility  and chemotaxis, contribute to the biological fitness of the pathogen. For this,  deficiencies in the function of these features clearly reduce the pathogenicity of  <em>C. jejuni<\/em> without being a virulence factor per se.  Opposing to this, there are two essential requirements to determine the virulence  of <em>C. jejuni<\/em> which represent the adherence to, and the invasion of host cells.  Thereby, adherence, as a virulence factor, is mediated by many different bacterialderived  components like proteins but also by several oligo- and polysaccharide  structures that are linked to surface proteins but also to the flagella.  In addition, several invasion-relevant features of <em>C. jejuni<\/em> have been detected so  far. Whereas some of them are described functionally to modulate cytoskeleton  arrangement of the host cell, others are only described as invasion relevant.  Indeed, investigations with respect to the pathogenic potential of some adherence-  and invasion-relevant components did not give identical results indicating  that their relevance might depend on the interplay of the respective <em>C. jejuni<\/em>  strains used in these studies with the corresponding host cells.  This review summarizes the<em> C. jejuni<\/em> components for adherence to and invasion  of host cells together with their particular mode of action if known.<br><\/p><p>","keywords":["Campylobacter jejuni","adherence","invasion"],"zusammenfassung":"<\/p><p> <em>Campylobacter <\/em><em>(C.)<\/em><em> jejuni<\/em> ist der wichtigste gemeldete Erreger der bakteriellen  Diarrhoe. Neben den klassischen Durchfallsymptomen, einschlie\u00dflich Fieber und  abdominellen Kr\u00e4mpfen, k\u00f6nnen sich das Guillain-Barr\u00e9 Syndrom, aber auch  reaktive Arthritis im Anschluss an das infekti\u00f6se Geschehen einstellen. Verschiedene  Eigenschaften von <em>C. jejuni<\/em>, wie z. B. die Motilit\u00e4t aber auch Chemotaxis,  tragen zur biologischen Fitness des Erregers entscheidend bei. Einschr\u00e4nkungen  dieser F\u00e4higkeiten reduzieren die Pathogenit\u00e4t  von<em> C. jejuni<\/em>, ohne dabei per se als  Virulenzfaktoren gelten zu k\u00f6nnen.  Im Gegensatz hierzu stehen Faktoren des Erregers, die vor allem seine Virulenz  bestimmen, wie z. B. die Adh\u00e4renz an und die Invasion in Wirtszellen. Die Adh\u00e4renzeigenschaften  werden von verschiedenen bakteriellen Komponenten, wie  beispielsweise Proteinen, aber auch Oligo- und Polysaccharidstrukturen, welche  Protein-, aber auch Flagellar-gebunden sind, bestimmt. Zus\u00e4tzlich sind verschiedene  invasionsrelevante Komponenten von <em>C. jejuni <\/em>bekannt. W\u00e4hrend von  einigen dieser Invasionsfaktoren gezeigt werden konnte, dass sie die Zytoskelettstruktur  der Wirtszelle ver\u00e4ndern, sind andere lediglich als invasionsrelevant<br> beschrieben. Allerdings sind die Forschungsergebnisse im Hinblick auf die Bedeutung einiger Adh\u00e4renz- aber auch Invasionsfaktoren nicht einheitlich, was darauf  hinweisen k\u00f6nnte, dass die Funktion dieser Faktoren an den jeweiligen  <em>C. jejuni<\/em>-Stamm und die eingesetzte Wirtszelllinie gebunden ist.  Diese \u00dcbersichtsarbeit fasst die Faktoren von <em>C. jejuni<\/em> zusammen, welche die  Adh\u00e4renz an und die Invasion in Wirtszellen vermitteln. Der jeweilige Wirkungsmechanismus  der relevanten Proteine wird, soweit bekannt, beschrieben.<\/p><p>","schluesselwoerter":["Campylobacter jejuni","Adh\u00e4renz","Invasion"],"translatedTitle":"Campylobacter jejuni: Faktoren f\u00fcr Adh\u00e4renz an und Invasion von Eukaryontenzellen","abstractE":" Campylobacter (C.) jejuni is the most important reported cause for bacterial diarrhoea.  The infection can be accompanied by fever and abdominal cramps and  in rare cases the Guillain-Barr\u00e9 syndrome or reactive arthritis can develop as a  post-infection complication. Several biological properties of C. jejuni, e. g. motility  and chemotaxis, contribute to the biological fitness of the pathogen. For this,  deficiencies in the function of these features clearly reduce the pathogenicity of  C. jejuni without being a virulence factor per se.  Opposing to this, there are two essential requirements to determine the virulence  of C. jejuni which represent the adherence to, and the invasion of host cells.  Thereby, adherence, as a virulence factor, is mediated by many different bacterialderived  components like proteins but also by several oligo- and polysaccharide  structures that are linked to surface proteins but also to the flagella.  In addition, several invasion-relevant features of C. jejuni have been detected so  far. Whereas some of them are described functionally to modulate cytoskeleton  arrangement of the host cell, others are only described as invasion relevant.  Indeed, investigations with respect to the pathogenic potential of some adherence-  and invasion-relevant components did not give identical results indicating  that their relevance might depend on the interplay of the respective C. jejuni  strains used in these studies with the corresponding host cells.  This review summarizes the C. jejuni components for adherence to and invasion  of host cells together with their particular mode of action if known.","date":{"year":2014,"date":"12\/2014","accepted":"2014-12-17"},"volume":"128","openAccess":true,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"90-97","redirects":["campylobacter-jejuni-components-for-adherence-to-and-invasion-of-eukaryotic-cells\/150\/3216\/84283"],"tierartCategories":[],"artikelartCategories":["Open Access","Abostufe frei"]}
CY - Hannover
DA - 12/2014
DO - 10.2376/0005-9366-128-90
LA - English
N2 -  Campylobacter (C.) jejuni is the most important reported cause for bacterial diarrhoea.  The infection can be accompanied by fever and abdominal cramps and  in rare cases the Guillain-Barré syndrome or reactive arthritis can develop as a  post-infection complication. Several biological properties of C. jejuni, e. g. motility  and chemotaxis, contribute to the biological fitness of the pathogen. For this,  deficiencies in the function of these features clearly reduce the pathogenicity of  C. jejuni without being a virulence factor per se.  Opposing to this, there are two essential requirements to determine the virulence  of C. jejuni which represent the adherence to, and the invasion of host cells.  Thereby, adherence, as a virulence factor, is mediated by many different bacterialderived  components like proteins but also by several oligo- and polysaccharide  structures that are linked to surface proteins but also to the flagella.  In addition, several invasion-relevant features of C. jejuni have been detected so  far. Whereas some of them are described functionally to modulate cytoskeleton  arrangement of the host cell, others are only described as invasion relevant.  Indeed, investigations with respect to the pathogenic potential of some adherence-  and invasion-relevant components did not give identical results indicating  that their relevance might depend on the interplay of the respective C. jejuni  strains used in these studies with the corresponding host cells.  This review summarizes the C. jejuni components for adherence to and invasion  of host cells together with their particular mode of action if known.
PB - Schlütersche Verlagsgesellschaft mbH & Co. KG
PP - Hannover
PY - 2014
SP - 90
EP - 97
T1 - Campylobacter jejuni: Components for adherence to and invasion of eukaryotic cells
T2 - Berliner und Münchener Tierärztliche Wochenschrift
TI - Campylobacter jejuni: Components for adherence to and invasion of eukaryotic cells
TT - Campylobacter jejuni: Faktoren für Adhärenz an und Invasion von Eukaryontenzellen
VL - 128
SN - 0005-9366
ER -