TY - JOUR KW - 3R strategy KW - 3D printing KW - nasal drug deposition AU - J Flamm AU - M Boscher AU - F Maigler AU - C Akana AU - J Lindemann AU - S Kleiner AU - F Sommer AU - K Schindowski AB - The aim of the „3D for 3R“ project was to generate anatomical 3D models of the murine nasal cavity with rapid prototyping to establish a refined region-specific intranasal drug delivery technique targeting either the respiratory or the olfactory epithelium in mice. The anatomical structure of the murine nasal cavity was resolved by x-ray computer tomography and the data sets of the CT-scans were used to construct anatomical prototypes that were manufactured by 3D-printing, stereolithography or vacuum moulding. In the present study we show the successful construction of such anatomical 3D models and their use to establish intranasal application techniques under 3R criteria to minimize the use of laboratory animals. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":108530,"title":"Standardized refined intranasal administration for region-specific intranasal drug deposition in mice established with 3D rapid prototypes under 3R criteria","topline":"","teaserText":"Etablierung einer standardisierten und optimierten regiospezifischen intranasalen Applikationsmethode an der Maus mit Hilfe von 3D-Modellen unter 3R-Kriterien","content":"

Summary<\/span>
The aim of the \u201e3D for 3R\u201c project was to generate anatomical 3D models of the murine nasal cavity with rapid prototyping to establish a refined region-specific intranasal drug delivery technique targeting either the respiratory or the olfactory epithelium in mice. The anatomical structure of the murine nasal cavity was resolved by x-ray computer tomography and the data sets of the CT-scans were used to construct anatomical prototypes that were manufactured by 3D-printing, stereolithography or vacuum moulding. In the present study we show the successful construction of such anatomical 3D models and their use to establish intranasal application techniques under 3R criteria to minimize the use of laboratory animals.<\/p>

Keywords<\/span>
3R strategy, 3D printing, nasal drug deposition<\/p>

Zusammenfassung<\/span>
Das Ziel des Projekts \u201e3D f\u00fcr 3R\u201c war die Erstellung von anatomischen 3D-Modellen der Nasenh\u00f6hle von M\u00e4usen, um eine verfeinerte regio-spezifische intranasale Darreichungsmethode zu entwickeln, die spezifisch entweder das respiratorische oder das olfaktorische Epithel erreichen soll. Die Anatomie der murinen Nasenh\u00f6hle wurde durch Computertomographie dargestellt und die Datens\u00e4tze wurden verwendet, um anatomisch korrekte Modelle zu konstruieren, die mittels 3D-Druck, Stereolithographie oder Vakuumgussverfahren hergestellt wurden. In der vorliegenden Studie zeigen wir die erfolgreiche Konstruktion solcher anatomischer 3D-Modelle und deren Verwendung zur Etablierung intranasaler Applikationstechniken unter 3R-Kriterien, um den Einsatz von Labortieren zu minimieren.<\/p>

Schl\u00fcsselw\u00f6rter<\/span>
3R-Strategie, 3D-Druck, regio-spezifische Darreichung<\/p>","categories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"],"fromDate":"Jun 26, 2018 11:46:09 AM","oldUrls":["http:\/\/vetline.de\/standardized-refined-intranasal-administration-for-region-specific-intranasal-drug-deposition-in-mice-established-with-3d-rapid-prototypes-under-3r-criteria\/150\/3130\/108530"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl M\u00fcnch Tier\u00e4rztl Wochensch","doiDocumentUri":"https:\/\/vetline.de\/files\/smfiledata\/7\/2\/3\/7\/8\/3\/BMTW_AOP_17102_Schindowski.pdf","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochenschc","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-17102","doiFirstPage":".","doiLastPage":"..","doiTransmitted":true,"doiAuthor":"Flamm J, Boscher M, Maigler F, Akana C, Lindemann J, Kleiner S, Sommer F, Schindowski K","pdf":{"path":"http:\/\/data\/BMTW_AOP_17102_Schindowski.pdf","title":"BMTW_AOP_17102_Schindowski","description":"Standardized refined intranasal administration for region-specific intranasal drug deposition in mice established with 3D rapid prototypes under 3R criteria"},"authors":[{"firstName":"J","middleName":"","lastName":"Flamm"},{"firstName":"M","middleName":"","lastName":"Boscher"},{"firstName":"F","middleName":"","lastName":"Maigler"},{"firstName":"C","middleName":"","lastName":"Akana"},{"firstName":"J","middleName":"","lastName":"Lindemann"},{"firstName":"S","middleName":"","lastName":"Kleiner"},{"firstName":"F","middleName":"","lastName":"Sommer"},{"firstName":"K","middleName":"","lastName":"Schindowski"}],"contentOptimised":"

Summary<\/strong>
The aim of the \u201e3D for 3R\u201c project was to generate anatomical 3D models of the murine nasal cavity with rapid prototyping to establish a refined region-specific intranasal drug delivery technique targeting either the respiratory or the olfactory epithelium in mice. The anatomical structure of the murine nasal cavity was resolved by x-ray computer tomography and the data sets of the CT-scans were used to construct anatomical prototypes that were manufactured by 3D-printing, stereolithography or vacuum moulding. In the present study we show the successful construction of such anatomical 3D models and their use to establish intranasal application techniques under 3R criteria to minimize the use of laboratory animals.<\/p>

Keywords:<\/strong>
3R strategy, 3D printing, nasal drug deposition<\/p>

Zusammenfassung<\/strong>
Das Ziel des Projekts \u201e3D f\u00fcr 3R\u201c war die Erstellung von anatomischen 3D-Modellen der Nasenh\u00f6hle von M\u00e4usen, um eine verfeinerte regio-spezifische intranasale Darreichungsmethode zu entwickeln, die spezifisch entweder das respiratorische oder das olfaktorische Epithel erreichen soll. Die Anatomie der murinen Nasenh\u00f6hle wurde durch Computertomographie dargestellt und die Datens\u00e4tze wurden verwendet, um anatomisch korrekte Modelle zu konstruieren, die mittels 3D-Druck, Stereolithographie oder Vakuumgussverfahren hergestellt wurden. In der vorliegenden Studie zeigen wir die erfolgreiche Konstruktion solcher anatomischer 3D-Modelle und deren Verwendung zur Etablierung intranasaler Applikationstechniken unter 3R-Kriterien, um den Einsatz von Labortieren zu minimieren.<\/p>

Schl\u00fcsselw\u00f6rter:<\/strong>
3R-Strategie, 3D-Druck, regio-spezifische Darreichung<\/p>","primaryLanguage":"englisch","summary":"The aim of the \u201e3D for 3R\u201c project was to generate anatomical 3D models of the murine nasal cavity with rapid prototyping to establish a refined region-specific intranasal drug delivery technique targeting either the respiratory or the olfactory epithelium in mice. The anatomical structure of the murine nasal cavity was resolved by x-ray computer tomography and the data sets of the CT-scans were used to construct anatomical prototypes that were manufactured by 3D-printing, stereolithography or vacuum moulding. In the present study we show the successful construction of such anatomical 3D models and their use to establish intranasal application techniques under 3R criteria to minimize the use of laboratory animals.<\/p>

","keywords":["3R strategy","3D printing","nasal drug deposition"],"zusammenfassung":"Das Ziel des Projekts \u201e3D f\u00fcr 3R\u201c war die Erstellung von anatomischen 3D-Modellen der Nasenh\u00f6hle von M\u00e4usen, um eine verfeinerte regio-spezifische intranasale Darreichungsmethode zu entwickeln, die spezifisch entweder das respiratorische oder das olfaktorische Epithel erreichen soll. Die Anatomie der murinen Nasenh\u00f6hle wurde durch Computertomographie dargestellt und die Datens\u00e4tze wurden verwendet, um anatomisch korrekte Modelle zu konstruieren, die mittels 3D-Druck, Stereolithographie oder Vakuumgussverfahren hergestellt wurden. In der vorliegenden Studie zeigen wir die erfolgreiche Konstruktion solcher anatomischer 3D-Modelle und deren Verwendung zur Etablierung intranasaler Applikationstechniken unter 3R-Kriterien, um den Einsatz von Labortieren zu minimieren.<\/p>

","schluesselwoerter":["3R-Strategie","3D-Druck","regio-spezifische Darreichung"],"translatedTitle":"Etablierung einer standardisierten und optimierten regiospezifischen intranasalen Applikationsmethode an der Maus mit Hilfe von 3D-Modellen unter 3R-Kriterien","abstractE":"The aim of the \u201e3D for 3R\u201c project was to generate anatomical 3D models of the murine nasal cavity with rapid prototyping to establish a refined region-specific intranasal drug delivery technique targeting either the respiratory or the olfactory epithelium in mice. The anatomical structure of the murine nasal cavity was resolved by x-ray computer tomography and the data sets of the CT-scans were used to construct anatomical prototypes that were manufactured by 3D-printing, stereolithography or vacuum moulding. In the present study we show the successful construction of such anatomical 3D models and their use to establish intranasal application techniques under 3R criteria to minimize the use of laboratory animals.","date":{"year":2018,"date":"06\/2018","accepted":"2018-06-26"},"volume":131,"openAccess":false,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"","redirects":["standardized-refined-intranasal-administration-for-region-specific-intranasal-drug-deposition-in-mice-established-with-3d-rapid-prototypes-under-3r-criteria\/150\/3130\/108530"],"tierartCategories":[],"artikelartCategories":["Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel"]} CY - Hannover DA - 06/2018 DO - 10.2376/0005-9366-17102 LA - English N2 - The aim of the „3D for 3R“ project was to generate anatomical 3D models of the murine nasal cavity with rapid prototyping to establish a refined region-specific intranasal drug delivery technique targeting either the respiratory or the olfactory epithelium in mice. The anatomical structure of the murine nasal cavity was resolved by x-ray computer tomography and the data sets of the CT-scans were used to construct anatomical prototypes that were manufactured by 3D-printing, stereolithography or vacuum moulding. In the present study we show the successful construction of such anatomical 3D models and their use to establish intranasal application techniques under 3R criteria to minimize the use of laboratory animals. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2018 T1 - Standardized refined intranasal administration for region-specific intranasal drug deposition in mice established with 3D rapid prototypes under 3R criteria T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Standardized refined intranasal administration for region-specific intranasal drug deposition in mice established with 3D rapid prototypes under 3R criteria TT - Etablierung einer standardisierten und optimierten regiospezifischen intranasalen Applikationsmethode an der Maus mit Hilfe von 3D-Modellen unter 3R-Kriterien VL - 131 SN - 0005-9366 ER -