TY - JOUR KW - equine piroplasmosis KW - Babesia caballi KW - acute renal failure KW - nested PCR KW - cELISA AU - M Adam AU - J Pikalo AU - A Snyder AU - A Steinrigl AU - G Köller AU - G Schusser AB - A 14 year-old gelding was diagnosed with acute equine piroplasmosis caused by Babesia (B.) caballi infection using IFAT, microscopy and nested PCR. The horse was presented with a high fever (40.8°C), apathy and inappetence. Clinical examination revealed tachycardia (96 beats/min), tachypnoea (20 breaths/min), icteric mucous membranes, and sternal and preputial oedema. Blood tests showed moderate anaemia and thrombocytopaenia, severe azotaemia and increased plasma free haemoglobin. Urinary tests revealed a highly decreased glomerular filtration rate (GFR) and an increased gamma-GT:creatinine ratio indicating acute renal failure. Intraerythrocytic merozoites of B. caballi were detected in the blood smear. The patient was treated with imidocarb dipropionate (Carbesia®) for B. caballi infection and dopamine to correct the GFR. However, the horse continued to deteriorate and the animal’s owner decided to euthanize before the second dose of Carbesia. The necropsy revealed acute renal failure, which was caused mainly by membranoproliferative glomerulonephritis, in addition to moderate inflammatory signs in the brain, liver and myocardium. B. caballi can cause severe multiple organ dysfunction, and parameters such as plasma-free haemoglobin, urinary GFR and gamma-GT:creatinine ratio could be helpful indicators of an upcoming renal problem in horses. BT - Berliner und Münchener Tierärztliche Wochenschrift C1 - {"oldId":99050,"title":"Equine Piroplasmosis \u2013 a case of severe Babesia caballi infection associated with acute renal failure","topline":"Open Access","teaserText":"Equine Piroplasmose \u2013 ein Fall mit schwerer Babesia caballi-Infektion und akutem renalen Nierenversagen","content":"

Summary<\/span>
A 14 year-old gelding was diagnosed with acute equine piroplasmosis caused by Babesia (B.) caballi<\/span> infection using IFAT, microscopy and nested PCR. The horse was presented with a high fever (40.8\u00b0C), apathy and inappetence. Clinical examination revealed tachycardia (96 beats\/min), tachypnoea (20 breaths\/min), icteric mucous membranes, and sternal and preputial oedema. Blood tests showed moderate anaemia and thrombocytopaenia, severe azotaemia and increased plasma free haemoglobin. Urinary tests revealed a highly decreased glomerular filtration rate (GFR) and an increased gamma-GT:creatinine ratio indicating acute renal failure. Intraerythrocytic merozoites of B. caballi <\/span>were detected in the blood smear. The patient was treated with imidocarb dipropionate (Carbesia\u00ae<\/span>) for B. caballi<\/span> infection and dopamine to correct the GFR. However, the horse continued to deteriorate and the animal\u2019s owner decided to euthanize before the second dose of Carbesia. The necropsy revealed acute renal failure, which was caused mainly by membranoproliferative glomerulonephritis, in addition to moderate inflammatory signs in the brain, liver and myocardium. B. caballi<\/span> can cause severe multiple organ dysfunction, and parameters such as plasma-free haemoglobin, urinary GFR and gamma-GT:creatinine ratio could be helpful indicators of an upcoming renal problem in horses.

Keywords:<\/span> equine piroplasmosis, Babesia caball<\/span>i, acute renal failure, nested PCR, cELISA<\/p>


Zusammenfassung<\/span>
Piroplasmose wurde bei einem 14 Jahre alten Bretonischen Kaltblutwallach aufgrund der intraerythrozyt\u00e4ren Merozoiten, des IFAT und der nested PCR diagnostiziert. Der Wallach wurde mit Apathie, hohem Fieber (40,8 \u00b0C) und Inappetenz eingeliefert. Weitere klinische Befunde waren Tachykardie (96\/min), Tachypnoe (20\/min), ikterische Schleimh\u00e4ute, Unterbrust- und Unterbauch\u00f6dem sowie Pr\u00e4putial\u00f6dem. Mittelgradige An\u00e4mie, Thrombozytopenie, hochgradige Azot\u00e4mie, erh\u00f6hte intravaskul\u00e4re H\u00e4moglobinkonzentration, hochgradig verminderte glomerul\u00e4re Filtrationsrate (GFR) und ein erh\u00f6htes gamma-GT:Kreatinin-Verh\u00e4ltnis waren labormedizinisch feststellbar. Intraerythrozyt\u00e4re
Merozoite von Babesia (B.) caballi<\/span> waren im Blutausstrich nachweisbar. Der Wallach wurde mit 4 mg Imidocarbdipropionat (Carbesia\u00ae<\/span>) pro kg K\u00f6rpermasse i. m. gegen die
B. caballi-<\/span>Infektion behandelt und Dopamin wurde verabreicht, um die GFR zu verbessern. Der klinische Zustand des Wallaches verschlechterte sich dramatisch, sodass dieser auf Wunsch des Besitzers euthanasiert wurde. Die Obduktionsergebnisse waren proliferative Glomerulonephritis, entz\u00fcndliche Ver\u00e4nderungen im Gehirn, Leber und Myokard. B. caballi<\/span> kann schwere, multiple Organfunktionsst\u00f6rungen hervorrufen. Die erh\u00f6hte, freie H\u00e4moglobinkonzentration zeigt die intravaskul\u00e4re Erythrozytolyse an und die erniedrigte GFR sowie das erh\u00f6hte gamma-GT-Kreatinin-Verh\u00e4ltnis sind wichtige Indikatoren f\u00fcr das Vorhandensein eines akuten renalen Nierenversagens beim Pferd.

Schl\u00fcsselw\u00f6rter<\/span>: Equine Piroplasmose, Babesia caballi<\/span>, akutes Nierenversagen, PCR, cELISA<\/p>","categories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"],"fromDate":"Nov 15, 2016 8:54:13 AM","oldUrls":["http:\/\/vetline.de\/equine-piroplasmosis-a-case-of-severe-babesia-caballi-infection-associated-with-acute-renal-failure\/150\/3130\/99050","http:\/\/vetline.de\/equine-piroplasmosis-a-case-of-severe-babesia-caballi-infection-associated-with-acute-renal-failure\/150\/3216\/99050"],"doiLanguage":"englisch","doiProductFormat":"online","doiPublisher":"Schl\u00fctersche Verlagsgesellschaft mbH & Co. KG","doiSerialWorkTitle":"Berl M\u00fcnch Tier\u00e4rztl Wochensch","doiDocumentUri":"http:\/\/cf01.vetline.schluetersche.de\/files\/smfiledata\/6\/1\/5\/6\/3\/7\/BMW_2017_03_04_16064_Schusser_onl300.pdf","doiSource":"Berl M\u00fcnch Tier\u00e4rztl Wochensch","doiissn":"0005-9366","doiNr":"10.2376\/0005-9366-16064","doiFirstPage":".","doiLastPage":"..","doiTransmitted":true,"doiAuthor":"Adam M, Pikalo J, Snyder A, Steinrigl A, K\u00f6ller G, Schusser GF","pdf":{"path":"http:\/\/data\/BMW_2017_03_04_16064_Schusser_onl300.pdf","title":"OA BMTW 16064 Schusser","description":""},"authors":[{"firstName":"M","middleName":"","lastName":"Adam"},{"firstName":"J","middleName":"","lastName":"Pikalo"},{"firstName":"A","middleName":"","lastName":"Snyder"},{"firstName":"A","middleName":"","lastName":"Steinrigl"},{"firstName":"G","middleName":"","lastName":"K\u00f6ller"},{"firstName":"G","middleName":"F","lastName":"Schusser"}],"contentOptimised":"

Summary<\/strong>
A 14 year-old gelding was diagnosed with acute equine piroplasmosis caused by Babesia (B.) caballi<\/em> infection using IFAT, microscopy and nested PCR. The horse was presented with a high fever (40.8\u00b0C), apathy and inappetence. Clinical examination revealed tachycardia (96 beats\/min), tachypnoea (20 breaths\/min), icteric mucous membranes, and sternal and preputial oedema. Blood tests showed moderate anaemia and thrombocytopaenia, severe azotaemia and increased plasma free haemoglobin. Urinary tests revealed a highly decreased glomerular filtration rate (GFR) and an increased gamma-GT:creatinine ratio indicating acute renal failure. Intraerythrocytic merozoites of B. caballi <\/em>were detected in the blood smear. The patient was treated with imidocarb dipropionate (Carbesia\u00ae) for B. caballi<\/em> infection and dopamine to correct the GFR. However, the horse continued to deteriorate and the animal\u2019s owner decided to euthanize before the second dose of Carbesia. The necropsy revealed acute renal failure, which was caused mainly by membranoproliferative glomerulonephritis, in addition to moderate inflammatory signs in the brain, liver and myocardium. B. caballi<\/em> can cause severe multiple organ dysfunction, and parameters such as plasma-free haemoglobin, urinary GFR and gamma-GT:creatinine ratio could be helpful indicators of an upcoming renal problem in horses.

Keywords:<\/strong> equine piroplasmosis, Babesia caball<\/em>i, acute renal failure, nested PCR, cELISA<\/p>


Zusammenfassung<\/strong>
Piroplasmose wurde bei einem 14 Jahre alten Bretonischen Kaltblutwallach aufgrund der intraerythrozyt\u00e4ren Merozoiten, des IFAT und der nested PCR diagnostiziert. Der Wallach wurde mit Apathie, hohem Fieber (40,8 \u00b0C) und Inappetenz eingeliefert. Weitere klinische Befunde waren Tachykardie (96\/min), Tachypnoe (20\/min), ikterische Schleimh\u00e4ute, Unterbrust- und Unterbauch\u00f6dem sowie Pr\u00e4putial\u00f6dem. Mittelgradige An\u00e4mie, Thrombozytopenie, hochgradige Azot\u00e4mie, erh\u00f6hte intravaskul\u00e4re H\u00e4moglobinkonzentration, hochgradig verminderte glomerul\u00e4re Filtrationsrate (GFR) und ein erh\u00f6htes gamma-GT:Kreatinin-Verh\u00e4ltnis waren labormedizinisch feststellbar. Intraerythrozyt\u00e4re
Merozoite von Babesia (B.) caballi<\/em> waren im Blutausstrich nachweisbar. Der Wallach wurde mit 4 mg Imidocarbdipropionat (Carbesia\u00ae) pro kg K\u00f6rpermasse i. m. gegen die
B. caballi-<\/em>Infektion behandelt und Dopamin wurde verabreicht, um die GFR zu verbessern. Der klinische Zustand des Wallaches verschlechterte sich dramatisch, sodass dieser auf Wunsch des Besitzers euthanasiert wurde. Die Obduktionsergebnisse waren proliferative Glomerulonephritis, entz\u00fcndliche Ver\u00e4nderungen im Gehirn, Leber und Myokard. B. caballi<\/em> kann schwere, multiple Organfunktionsst\u00f6rungen hervorrufen. Die erh\u00f6hte, freie H\u00e4moglobinkonzentration zeigt die intravaskul\u00e4re Erythrozytolyse an und die erniedrigte GFR sowie das erh\u00f6hte gamma-GT-Kreatinin-Verh\u00e4ltnis sind wichtige Indikatoren f\u00fcr das Vorhandensein eines akuten renalen Nierenversagens beim Pferd.

Schl\u00fcsselw\u00f6rter:<\/strong>: Equine Piroplasmose, Babesia caballi<\/em>, akutes Nierenversagen, PCR, cELISA<\/p>","primaryLanguage":"englisch","summary":"A 14 year-old gelding was diagnosed with acute equine piroplasmosis caused by Babesia (B.) caballi<\/em> infection using IFAT, microscopy and nested PCR. The horse was presented with a high fever (40.8\u00b0C), apathy and inappetence. Clinical examination revealed tachycardia (96 beats\/min), tachypnoea (20 breaths\/min), icteric mucous membranes, and sternal and preputial oedema. Blood tests showed moderate anaemia and thrombocytopaenia, severe azotaemia and increased plasma free haemoglobin. Urinary tests revealed a highly decreased glomerular filtration rate (GFR) and an increased gamma-GT:creatinine ratio indicating acute renal failure. Intraerythrocytic merozoites of B. caballi <\/em>were detected in the blood smear. The patient was treated with imidocarb dipropionate (Carbesia\u00ae) for B. caballi<\/em> infection and dopamine to correct the GFR. However, the horse continued to deteriorate and the animal\u2019s owner decided to euthanize before the second dose of Carbesia. The necropsy revealed acute renal failure, which was caused mainly by membranoproliferative glomerulonephritis, in addition to moderate inflammatory signs in the brain, liver and myocardium. B. caballi<\/em> can cause severe multiple organ dysfunction, and parameters such as plasma-free haemoglobin, urinary GFR and gamma-GT:creatinine ratio could be helpful indicators of an upcoming renal problem in horses.","keywords":["equine piroplasmosis","Babesia caball"],"zusammenfassung":"Piroplasmose wurde bei einem 14 Jahre alten Bretonischen Kaltblutwallach aufgrund der intraerythrozyt\u00e4ren Merozoiten, des IFAT und der nested PCR diagnostiziert. Der Wallach wurde mit Apathie, hohem Fieber (40,8 \u00b0C) und Inappetenz eingeliefert. Weitere klinische Befunde waren Tachykardie (96\/min), Tachypnoe (20\/min), ikterische Schleimh\u00e4ute, Unterbrust- und Unterbauch\u00f6dem sowie Pr\u00e4putial\u00f6dem. Mittelgradige An\u00e4mie, Thrombozytopenie, hochgradige Azot\u00e4mie, erh\u00f6hte intravaskul\u00e4re H\u00e4moglobinkonzentration, hochgradig verminderte glomerul\u00e4re Filtrationsrate (GFR) und ein erh\u00f6htes gamma-GT:Kreatinin-Verh\u00e4ltnis waren labormedizinisch feststellbar. Intraerythrozyt\u00e4re
Merozoite von Babesia (B.) caballi<\/em> waren im Blutausstrich nachweisbar. Der Wallach wurde mit 4 mg Imidocarbdipropionat (Carbesia\u00ae) pro kg K\u00f6rpermasse i. m. gegen die
B. caballi-<\/em>Infektion behandelt und Dopamin wurde verabreicht, um die GFR zu verbessern. Der klinische Zustand des Wallaches verschlechterte sich dramatisch, sodass dieser auf Wunsch des Besitzers euthanasiert wurde. Die Obduktionsergebnisse waren proliferative Glomerulonephritis, entz\u00fcndliche Ver\u00e4nderungen im Gehirn, Leber und Myokard. B. caballi<\/em> kann schwere, multiple Organfunktionsst\u00f6rungen hervorrufen. Die erh\u00f6hte, freie H\u00e4moglobinkonzentration zeigt die intravaskul\u00e4re Erythrozytolyse an und die erniedrigte GFR sowie das erh\u00f6hte gamma-GT-Kreatinin-Verh\u00e4ltnis sind wichtige Indikatoren f\u00fcr das Vorhandensein eines akuten renalen Nierenversagens beim Pferd.","schluesselwoerter":[": Equine Piroplasmose","Babesia caballi"],"translatedTitle":"Equine Piroplasmose \u2013 ein Fall mit schwerer Babesia caballi-Infektion und akutem renalen Nierenversagen","abstractE":"A 14 year-old gelding was diagnosed with acute equine piroplasmosis caused by Babesia (B.) caballi infection using IFAT, microscopy and nested PCR. The horse was presented with a high fever (40.8\u00b0C), apathy and inappetence. Clinical examination revealed tachycardia (96 beats\/min), tachypnoea (20 breaths\/min), icteric mucous membranes, and sternal and preputial oedema. Blood tests showed moderate anaemia and thrombocytopaenia, severe azotaemia and increased plasma free haemoglobin. Urinary tests revealed a highly decreased glomerular filtration rate (GFR) and an increased gamma-GT:creatinine ratio indicating acute renal failure. Intraerythrocytic merozoites of B. caballi were detected in the blood smear. The patient was treated with imidocarb dipropionate (Carbesia\u00ae) for B. caballi infection and dopamine to correct the GFR. However, the horse continued to deteriorate and the animal\u2019s owner decided to euthanize before the second dose of Carbesia. The necropsy revealed acute renal failure, which was caused mainly by membranoproliferative glomerulonephritis, in addition to moderate inflammatory signs in the brain, liver and myocardium. B. caballi can cause severe multiple organ dysfunction, and parameters such as plasma-free haemoglobin, urinary GFR and gamma-GT:creatinine ratio could be helpful indicators of an upcoming renal problem in horses.","date":{"year":2016,"date":"11\/2016","accepted":"2016-11-15"},"volume":129,"openAccess":true,"journal":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift","titleImageId":944,"pages":"","redirects":["equine-piroplasmosis-a-case-of-severe-babesia-caballi-infection-associated-with-acute-renal-failure\/150\/3130\/99050","equine-piroplasmosis-a-case-of-severe-babesia-caballi-infection-associated-with-acute-renal-failure\/150\/3216\/99050"],"tierartCategories":[],"artikelartCategories":["Open Access","Tier\u00e4rztliche Wochenschrift","Abostufe BMTW","Fachartikel","Abostufe frei"]} CY - Hannover DA - 11/2016 DO - 10.2376/0005-9366-16064 ET - 3/4 LA - English N2 - A 14 year-old gelding was diagnosed with acute equine piroplasmosis caused by Babesia (B.) caballi infection using IFAT, microscopy and nested PCR. The horse was presented with a high fever (40.8°C), apathy and inappetence. Clinical examination revealed tachycardia (96 beats/min), tachypnoea (20 breaths/min), icteric mucous membranes, and sternal and preputial oedema. Blood tests showed moderate anaemia and thrombocytopaenia, severe azotaemia and increased plasma free haemoglobin. Urinary tests revealed a highly decreased glomerular filtration rate (GFR) and an increased gamma-GT:creatinine ratio indicating acute renal failure. Intraerythrocytic merozoites of B. caballi were detected in the blood smear. The patient was treated with imidocarb dipropionate (Carbesia®) for B. caballi infection and dopamine to correct the GFR. However, the horse continued to deteriorate and the animal’s owner decided to euthanize before the second dose of Carbesia. The necropsy revealed acute renal failure, which was caused mainly by membranoproliferative glomerulonephritis, in addition to moderate inflammatory signs in the brain, liver and myocardium. B. caballi can cause severe multiple organ dysfunction, and parameters such as plasma-free haemoglobin, urinary GFR and gamma-GT:creatinine ratio could be helpful indicators of an upcoming renal problem in horses. PB - Schlütersche Verlagsgesellschaft mbH & Co. KG PP - Hannover PY - 2016 T1 - Equine Piroplasmosis – a case of severe Babesia caballi infection associated with acute renal failure T2 - Berliner und Münchener Tierärztliche Wochenschrift TI - Equine Piroplasmosis – a case of severe Babesia caballi infection associated with acute renal failure TT - Equine Piroplasmose – ein Fall mit schwerer Babesia caballi-Infektion und akutem renalen Nierenversagen VL - 129 SN - 0005-9366 ER -