02191nas a2200253   4500000000100000000000100001008004100002260007000043653002000113653001300133653002200146653002700168653000800195100001700203700001300220700001800233700001400251245012500265250000900390300001200399490000800411520150400419022001401923       2015                            d  c09/2015bSchlütersche Verlagsgesellschaft mbH & Co. KGaHannover10aT-cell lymphoma10aleukemia10aperipheral nerves10acentral nervous system10apig1 aA v. Altrock1 aM Ganter1 aU Schwittlick1 aA Beineke00aMulticentric T-cell lymphoma accompanied by infiltration of the peripheral and central nervous system in a fattening pig  a9/10  a350-3540 v1283 aMulticentric lymphomas, usually of B-cell origin, are rather common neoplasms in pigs, which usually affect lymph nodes and different organ systems. An uncommon manifestation of malignant lymphoma represents neoplastic peripheral nerve involvement, which has been reported in human medicine. So far, only single cases of lymphoma with manifestation in peripheral nerves (known as neurolymphomatosis) without leukemic conversion have been mentioned in different animal species others than swine. The present case report describes the occurrence of a multicentric T-cell lymphoma in a fattening pig with marked leukocytosis. The pig was presented with symptoms of lethargy, weight loss, and fever. Bone marrow aspirate contained all stages of granulocytic and erythrocytic precursors, and a remarkable large number of eosinophiles and undifferentiated blasts. At necropsy, the carcass showed generalized lymphadenopathy and severe hepatosplenomegaly. Histological findings included neoplastic round cell infiltrations in lymph nodes, bone marrow, tonsils, lung, spleen, liver, kidneys, urinary bladder, small and large intestine, and meninges. Additionally, neoplastic cells were present in the sciatic and medial plantar nerve of the left hind leg. The diagnosis T-cell lymphoma was confirmed immunohistochemically. To the author's knowledge, this work represents the first report of peripheral nerve involvement in a pig with multicentric T-cell lymphoma accompanied by CNS involvement and leukemia.  a0005-9366