01387nas a2200205   4500000000100000000000100001008004100002260007000043653002800113653002800141653001200169100001300181700001500194245011200209250001000321300001200331490000800343520081600351022001401167       2017                            d  c11/2017bSchlütersche Verlagsgesellschaft mbH & Co. KGaHannover10aAge-related differences10aantibiotics disposition10apoultry1 aL Lashev1 aA Milanova00aImpact of age and growth of chickens and turkeys on pharmacokinetics of antibacterial drugs: A brief review  a11/12  a523-5280 v1303 aAnalysis based on data for pharmacokinetics of antibacterial drugs in chickens and turkeys at different ages was made. Lack of significant differences between both species was established, but such depending on breed related intensity of growth were registered. The elimination rate and total body clearance for part of investigated substances slowed down in meat-type breeds having intense growth. These changes depend on increase of weight gain and age. It is assumed that the changes are characteristic for turkeys, and meat-type chickens, but not for chicken breeds for eggs which grow considerably slower and do not accumulate muscle mass intensively. These relations are characteristic for substances excreted mainly by glomerular filtration but not for those that are mainly subject of tubular secretion.  a0005-9366