02123nas a2200241   4500000000100000008004100001260007000042653001400112653001800126653003100144653002500175653002400200653000900224100001100233700001700244700001400261245007400275250000800349300001200357490000800369520149000377022001401867       2015                            d  c07/2015bSchlütersche Verlagsgesellschaft mbH & Co. KGaHannover10ainfection10ableeding time10aplatelet function analyser10aplatelet aggregation10aprimary haemostasis10aSIRS1 aM Abid1 aK Kalbantner1 aR Mischke00aPlatelet function in dogs with bacterial infections and leishmaniasis  a7/8  a289-2960 v1283 aThe objective of this study was to examine the influence of bacterial infections or leishmaniasis on primary haemostasis in dogs. Capillary bleeding time, automatic platelet function analysis (PFA-100), turbidimetric platelet aggregation, impedance aggregometry, platelet count and, in addition, the haematocrit were investigated in 25 dogs with bacterial infections or leishmaniasis . Results of these diseased dogs were compared to the control group and additionally classified into two subgroups based on criteria of systemic inflammatory response syndrome (SIRS) (groups “SIRS” and “Non-SIRS”). Dogs with infections had a significantly prolonged closure time of the PFA-100 using both cartridges (e. g., collagen/ADP: 83 [55–301] vs. 65 [47–88] s; median [minimum–maximum]; p  lt; 0.0001), a significant decrease in maximal aggregation of the turbidimetric aggregometry (e. g., ADP-induced: 45.2 ± 26.8 vs. 67.3 ± 21.8%; mean ± SD; P = 0.003), a significant increase of collagen-induced impedance aggregometry and a significant suppression of arachidonic acid-induced impedance aggregometry. An enhanced collagen-induced impedance aggregation was the only significant difference between subgroups “SIRS” and “Non-SIRS”. In conclusion, although individual tests indicate enhanced platelet aggregation, most of the in vitro tests revealed a normal to moderately reduced functionality. The reduced aggregability may partly indicate preactivation of platelets.  a0005-9366