02072nas a2200253   4500000000100000000000100001008004100002260007000043653001200113653002800125653001500153653001300168100001500181700001400196700001300210700001300223700001500236700001600251245016000267300001000427490000800437520135900445022001401804       2011                            d  c02/2011bSchlütersche Verlagsgesellschaft mbH & Co. KGaHannover10achicken10aLive Salmonella vaccine10aSalmonella10azoonosis1 aS Springer1 aT Lindner1 aM Ahrens1 aG Woitow1 aF Prandini1 aH-J Selbitz00aDuration of immunity induced in chickens by an attenuated live Salmonella enteritidis vaccine and an inactivated Salmonella enteritidis/typhimurium vaccine  a89-930 v1243 aThe aim of this study was to examine the duration of immunity of different vaccination schemes using the S. enteritidis live vaccine Gallivac® Se and the S. enteritidis-S. typhimurium inactivated vaccine Gallimune® Se+St. Three groups of Lohman Brown chickens were used. Group one was vaccinated three times orally with Gallivac® Se at weeks one, seven and 13 of age. Group two was vaccinated twice orally with Gallivac® Se in weeks one and seven and once i.m. with Gallimune® Se+St in week 14 of age. A third group was not vaccinated and served as the control group. Eight randomly selected chickens from each of the three groups were challenged with a nalidixic acid resistant S. enteritidis PT4 strain in weeks 24, 51 and 71 of age and the same number of animals were challenged with a S. typhimurium DT 104 strain in weeks 26, 54 and 73 (75) of age. The chickens were euthanised seven days post challenge and the number of challenge strain organisms (log10 cfu) in the liver and on caecal mucosa was determined. The quantitative investigation of the challenge strain in the liver and caecal mucosa revealed a statistically significant (p  lt; 0.05) lower challenge strain burden in the vaccinated groups compared with the nonvaccinated control group up to week 71 (73) of age. The protective effects were demonstrated for both challenge strains.  a0005-9366