01564nas a2200181   4500000000100000000000100001008004100002260004400043100001400087700001400101700001300115700001300128245017900141300001000320490000800330520103000338022001401368       2008                            d  c01/2008bM. & H. Schaper GmbHaHannover1 aS Cenesiz1 aK Devrima1 aU Kamber1 aM Sozmen00aThe effect of kefir on glutathione (gsh), malondialdehyde (MDA) and nitric oxide (NO) levels in mice with colonic abnormal crypt formation (AcF) induced by azoxymethane (AOM)  a15-190 v1153 aIn this study we investigated the effect of kefir on the levels of glutathione (GSH),malondialdehyde (MDA), nitric oxide (NO) in the liver, stomach, spleen and colonof mice with colonic aberrant crypts formed by azoxymethane (AOM). Thirty 1weeks old Swiss Albino mice averaging 31.5 g weight were used as experimentalanimals. The mice were separated into 3 groups. The first group was the controlgroup, second group was the AOM and third group was the AOM+kefir group.We applied AOM to the second and third groups. Mice were fed ad libitum bylaboratory rodent chow during the experiment period. Water was given to thefirst and second groups and third group received only kefir diluted with water(50 %). AOM was injected subcutaneously to the second and third groups for 7weeks (two times a week, 5 mg/kg). Six weeks after the final AOM treatment theanimals were sacrificed and liver, stomach, spleen and colon samples were collectedfrom all the groups. MDA level demonstrated an increase only in stomachfor the third group (p  a0341-6593