01364nas a2200157   4500000000100000000000100001008004100002260007000043100001600113700001400129245015400143300001200297490000800309520087500317022001401192       2007                            d  c07/2007bSchlütersche Verlagsgesellschaft mbH & Co. KGaHannover1 aK Creuzburg1 aH Schmidt00aShiga toxin-producing Escherichio coli and their Bacteriophages as a Model for the Analysis of Virulence and Stress Response of a Food-Borne Pathogen  a288-2950 v1203 aEnterohemorrhagic Escherichia coli (EHEC) are a subgroup of Shiga toxin-producing Escherichia coli (STEC) that are able to cause serious food-borne intestina diseases which can be followed in 5 to 15 % by extraintestinal seguelae such as the hemolytic-uremic syndrome (HUS).One of the major pathogenicity factors of EHEC is the production of one or more Shiga toxins (Stx), which act as inhibitors of protein biosynthesis and have profound effects on the Signal transduction and immunological response in eukaryotic cells.The stx genes are located in the genome of heterogeneous, lambdoid, functional or cryptic bacteriophages and are expressed during the phage life cycle. Due to the linkage between the phage life cycle and sfxexpression,STEC and their bacteriophages are useful as a model for the analysis of stress response and virulence of this food-borne pathogen.  a0005-9366