02177nas a2200205   4500000000100000000000100001008004100002260007000043653002500113653001400138653001300152100001300165700001200178700001400190245008700204300001000291490000800301520164800309022001401957       2014                            d  c12/2014bSchlütersche Verlagsgesellschaft mbH & Co. KGaHannover10aCampylobacter jejuni10aadherence10ainvasion1 aR Lugert1 aU Groß1 aA Zautner00aCampylobacter jejuni: Components for adherence to and invasion of eukaryotic cells  a90-970 v1283 a Campylobacter (C.) jejuni is the most important reported cause for bacterial diarrhoea.  The infection can be accompanied by fever and abdominal cramps and  in rare cases the Guillain-Barré syndrome or reactive arthritis can develop as a  post-infection complication. Several biological properties of C. jejuni, e. g. motility  and chemotaxis, contribute to the biological fitness of the pathogen. For this,  deficiencies in the function of these features clearly reduce the pathogenicity of  C. jejuni without being a virulence factor per se.  Opposing to this, there are two essential requirements to determine the virulence  of C. jejuni which represent the adherence to, and the invasion of host cells.  Thereby, adherence, as a virulence factor, is mediated by many different bacterialderived  components like proteins but also by several oligo- and polysaccharide  structures that are linked to surface proteins but also to the flagella.  In addition, several invasion-relevant features of C. jejuni have been detected so  far. Whereas some of them are described functionally to modulate cytoskeleton  arrangement of the host cell, others are only described as invasion relevant.  Indeed, investigations with respect to the pathogenic potential of some adherence-  and invasion-relevant components did not give identical results indicating  that their relevance might depend on the interplay of the respective C. jejuni  strains used in these studies with the corresponding host cells.  This review summarizes the C. jejuni components for adherence to and invasion  of host cells together with their particular mode of action if known.  a0005-9366