@article{4099, keywords = {infection, bleeding time, platelet function analyser, platelet aggregation, primary haemostasis, SIRS}, author = {M Abid and K Kalbantner and R Mischke}, title = {Platelet function in dogs with bacterial infections and leishmaniasis}, abstract = {The objective of this study was to examine the influence of bacterial infections or leishmaniasis on primary haemostasis in dogs. Capillary bleeding time, automatic platelet function analysis (PFA-100), turbidimetric platelet aggregation, impedance aggregometry, platelet count and, in addition, the haematocrit were investigated in 25 dogs with bacterial infections or leishmaniasis . Results of these diseased dogs were compared to the control group and additionally classified into two subgroups based on criteria of systemic inflammatory response syndrome (SIRS) (groups “SIRS” and “Non-SIRS”). Dogs with infections had a significantly prolonged closure time of the PFA-100 using both cartridges (e. g., collagen/ADP: 83 [55–301] vs. 65 [47–88] s; median [minimum–maximum]; p lt; 0.0001), a significant decrease in maximal aggregation of the turbidimetric aggregometry (e. g., ADP-induced: 45.2 ± 26.8 vs. 67.3 ± 21.8%; mean ± SD; P = 0.003), a significant increase of collagen-induced impedance aggregometry and a significant suppression of arachidonic acid-induced impedance aggregometry. An enhanced collagen-induced impedance aggregation was the only significant difference between subgroups “SIRS” and “Non-SIRS”. In conclusion, although individual tests indicate enhanced platelet aggregation, most of the in vitro tests revealed a normal to moderately reduced functionality. The reduced aggregability may partly indicate preactivation of platelets.}, year = {2015}, journal = {Berliner und Münchener Tierärztliche Wochenschrift}, volume = {128}, edition = {7/8}, pages = {289-296}, month = {07/2015}, publisher = {Schlütersche Verlagsgesellschaft mbH & Co. KG}, address = {Hannover}, issn = {0005-9366}, doi = {10.2376/0005-9366-128-289}, language = {English}, }