@article{3161,
  author = {A Goudah and S Sher Shah and H-C Shin and B-J Chang and J-H Shim and A Abd El-Aty},
  title = {Concentration-time courses of pefloxacin in plasma and milk of lactating she-camels  (Camelus dromedarius)},
  abstract = {Using the microbial inhibition test, the single-dose pharmacokinetics ofpefloxacin mesylate dehydrate were studied in six clinically normal lactatingshe-camels (Camelus dromedarius) after intravenous (IV) and intramuscular (IM)administration of 10 mg/kg body weight (bwt). Blood and milk samples werecollected intermittently for a 48 h period, and the pharmacokinetic variableswere calculated using compartmental and non-compartmental analyticalmethods. The plasma course of pefloxacin was best resolved to a two-compartmentopen model after IV administration and a two-compartment open modelwith first-order absorption after IM administration. Pefloxacin exhibits a longelimination-phase disposition half-life (t1/2N) of 4.89 ± 1.12 h after IV injectionand 5.73 ± 1.42 h after IM administration. The mean volume of distribution atsteady state (Vdss) and total body clearance (Cltot) values after IV dosing were1.18 ± 0.45 l/kgand 0.21 ± 0.10 l/kg/h, respectively. The observed peak plasmalevel (Cmax) of 3.6 ± 0.1  amp;#956;g/ml was rapidly attained at 0.75 h (the time of maximumconcentration Tmax) after IM administration. The areas under the concentrationversus time curves (AUCs) were 44.18 ± 9.68  amp;#956;g.h/ml and 29.42 ± 6.49  amp;#956;g.h/ml after IV and IM administration, respectively. The absolute bioavailability (F%)obtained after IM administration was 71.59 ± 12.45%. Milk was penetrated quickly,with a mean peak level of 3.24 ± 0.17  amp;#956;g/ml occurring at 1.0 h. The eliminationhalf-life was significantly shorter after IV versus IM administration (4.21 ± 0.84 hversus 5.32 ± 0.67 h, respectively). Ultimately, pefloxacin could be useful for treatmentof udder infections in she-camels after specific assessment of susceptiblemicroorganisms.},
  year = {2008},
  journal = {Berliner und Münchener Tierärztliche Wochenschrift},
  volume = {121},
  pages = {432-439},
  month = {11/2008},
  publisher = {Schlütersche Verlagsgesellschaft mbH & Co. KG},
  address = {Hannover},
  issn = {0005-9366},
  doi = {10.2376/0005-9366-121-432},
  language = {English},
}