@article{2928,
  author = {A Abd El-Aty and J-H Choi and J-H Park and J-H Shim},
  title = {An evaluation of the effect of repeated doses of oral activated charcoal on the depletion of enrofloxacin residual levels in chicken breast muscles},
  abstract = {The purpose of this study was to determine whether concurrent oral administra-tion of activated charcoal has an affect on the depletion of the residual concen-trations of enrofloxacin (ENRO) in chicken breast muscles. Sixty-four broilerchi-ckens were divided into four groups (n = 16 per group), one given a daily ora dose of enrofloxacin with feed at a dose of 10 mg/kg for 5 consecutive days (control group) and the others given the same dose of enrofloxacin simultane-ously with activated charcoal ata dose rate of 0.5,1,and 2 % of daily feed for 5 days (treatment groups). At the end of treatment, 2 hens were sacrificed at each of the sampling time points (6,12,18,48, 72,96,120 and 144 h after completion of dosing), breast muscles were collected and analyzed.Supercritical fluid extraction and high-performance liguid chromatography methods were used to determine the enrofloxacin residue levels in chicken breast muscles.The limit of guantifica-tion (LOQ) 16.5 ug/kg,was lowerthan the maximum residue levels (MRL) fixed by the Commission ofthe European Union. For all the time periods, charcoal treatment did not affect enrofloxacin tissue concentrations except at 12 and 48 h post treatment.To our knowledge, no studies on the depletion of enrofloxacin in the presence and absence of activated charcoal in chicken muscles have been perfor-med.Although our current understanding is incomplete, multiple dose activated charcoals may play a role in the therapy of overdose.To prove this, further investi-gation is warranted.},
  year = {2007},
  journal = {Berliner und Münchener Tierärztliche Wochenschrift},
  volume = {120},
  pages = {210-214},
  month = {05/2007},
  publisher = {Schlütersche Verlagsgesellschaft mbH & Co. KG},
  address = {Hannover},
  issn = {0005-9366},
  doi = {10.2376/0005-9366-120-210},
  language = {English},
}