@article{1391,
  keywords = {3R strategy, 3D printing, nasal drug deposition},
  author = {J Flamm and M Boscher and F Maigler and C Akana and J Lindemann and S Kleiner and F Sommer and K Schindowski},
  title = {Standardized refined intranasal administration for region-specific intranasal drug deposition in mice established with 3D rapid prototypes under 3R criteria},
  abstract = {The aim of the „3D for 3R“ project was to generate anatomical 3D models of the  murine nasal cavity with rapid prototyping to establish a refined region-specific  intranasal drug delivery technique targeting either the respiratory or the olfactory  epithelium in mice. The anatomical structure of the murine nasal cavity was  resolved by x-ray computer tomography and the data sets of the CT-scans were  used to construct anatomical prototypes that were manufactured by 3D-printing,  stereolithography or vacuum moulding. In the present study we show the successful  construction of such anatomical 3D models and their use to establish intranasal  application techniques under 3R criteria to minimize the use of laboratory animals.},
  year = {2018},
  journal = {Berliner und Münchener Tierärztliche Wochenschrift},
  volume = {131},
  month = {06/2018},
  publisher = {Schlütersche Verlagsgesellschaft mbH & Co. KG},
  address = {Hannover},
  issn = {0005-9366},
  doi = {10.2376/0005-9366-17102},
  language = {English},
}