@article{1237,
  keywords = {colic, gut ischemia, epithelial alteration, alcohol dehydrogenase, prognostic marker},
  author = {G Köller and M Breitenstein and N Graneß and S Recknagel and R Barsnick and U Walliser and W Scheidemann and A Bienert-Zeit and D Donandt and G Stadtbäumer and M Paar and H Hell and H-A Schoon and G Schusser},
  title = {Multi-centre study on the evaluation of alcohol dehydrogenase activity in the serum of horses with intestinal strangulation},
  abstract = {The diagnosis and especially the prognosis in horses with strangulating obstructions represent a particular challenge for the veterinarian. Reliable parameters are needed to facilitate choosing the right therapy.  In a study of Gomaa et al. (2011) it was found out that alcohol dehydrogenase (ADH) with an activity of  gt; 80 U/L in colic horses with small intestinal strangulation indicated for non-surviving with a sensitivity of 66.7% and a specificity of 94.4%. This current study documents the ADH activity in the serum of 70 horses with small intestinal strangulation and 11 horses with strangulation of the large intestine. Samples of all strangulated intestinal segments were evaluated histologically and clinical data of the horses were collected. The aim of this study was to investigate the relationship between serum ADH activity and the histologically detectable epithelial damage of the ischemic intestine, and the duration of colic, length of the strangulated intestinal part and clinical outcome. Horses with a colic duration of ≥ 4 hours and a ≥ 300 cm strangulated small intestine had significantly increased ADH activity of 41 U/L (median) compared to normal horses (16.3 U/L) and the ROC selected a cut-off value of 25 U/L with a sensitivity of 100% and a specificity of 77%. These horses had complete loss of the villus epithelium with necrosis of the epithelial crypt cells, which indicate a resection of the gut segment involved. Serum ADH activity was below 80 U/L in all horses that survived an intestinal resection.},
  year = {2016},
  journal = {Berliner und Münchener Tierärztliche Wochenschrift},
  volume = {129},
  month = {11/2016},
  publisher = {Schlütersche Verlagsgesellschaft mbH & Co. KG},
  address = {Hannover},
  issn = {0005-9366},
  doi = {10.2376/0005-9366-16074},
  language = {English},
}